The use of microbeams to investigate radiation damage in living cells. by Folkard, M, Prise, K, Grime, G, Kirkby, K, Vojnovic, B

“…The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. …”

Open-Source Intelligence for Detection of Radiological Events and Syndromes Following the Invasion of Ukraine in 2022: Observational Study by Haley Stone, David Heslop, Samsung Lim, Ines Sarmiento, Mohana Kunasekaran, C Raina MacIntyre

“…ResultsBoth EPIWATCH and Epitweetr identified signals of potential radiobiological events throughout Ukraine, particularly on March 4 in Kyiv, Bucha, and Chernobyl. …”
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The potential impact of relative biological effectiveness uncertainty on charged particle treatment prescriptions. by Jones, B, Underwood, T, Dale, R

“…In cases where CPT achieves an excellent degree of normal tissue sparing, the radiobiological factors become less important and any uncertainties in the tumour and healthy tissue RBE values are correspondingly less problematic. …”

A theoretical framework for prescribing radiotherapy dose distributions using patient-specific biological information. by South, C, Partridge, M, Evans, P

“…We present a formalism for using functional imaging both to derive patient-specific radiobiological properties and consequently to prescribe optimal nonuniform radiotherapy dose distributions. …”

Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac by Lucia Giuliano, Gaia Franciosini, Luigi Palumbo, Lilia Aggar, Marie Dutreix, Luigi Faillace, Vincent Favaudon, Giuseppe Felici, Federica Galante, Andrea Mostacci, Mauro Migliorati, Matteo Pacitti, Annalisa Patriarca, Sophie Heinrich

“…A campaign of tests and measurements was performed to obtain a full reliable characterizations of the electron beam and of the delivered dose, which are necessary to the radiobiological experiments. Methods: A Faraday cup was used to measure the electron charges in a single RF pulse. …”
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Comparative In Silico Analysis of Ultra-Hypofractionated Intensity-Modulated Photon Radiotherapy (IMRT) Versus Intensity-Modulated Proton Therapy (IMPT) in the Pre-Operative Treatm... by Emile Gogineni, Hao Chen, Alexandra C. Istl, Fabian M. Johnston, Amol Narang, Curtiland Deville

“…The prescription was 25 Gy radiobiological equivalents (GyEs) (radiobiological effective dose of 1.1) to the clinical target volume and 30 GyEs to the margin at risk, all in five fractions. …”
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Biological Evaluation of Grid versus 3D Conformal Radiotherapy in Bulky Head and Neck Cancer by Najah Abdulmuneem Alanizy, Ehab Marouf Attalla, Ahmed Mosa Abdelaal, Mohamed Nabil Yassen, Medhat Wahba Shafaa

“…Radiobiological results showed significant differences between the two methods, and dosimetric data obtained by the TPS for tumours for two plans were P < 0.05. …”
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Understanding radiation damage to cells using microbeams by Folkard, M, Prise, K, Shao, C, Gilchrist, S, Schettino, G, Michette, A, Vojnovic, B

“…This technique continues to be applied to the investigation of a number of phenomena currently of great interest to the radiobiological community. In particular, it is the study of so-called "non-targeted" effects (where cells are seen to respond indirectly to ionizing radiation) that are benefiting most from the use of microbeam approaches.…”

Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors by Prezado, Yolanda

“…Proton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintaining or enhancing tumor control effectiveness as compared with conventional radiotherapy. …”
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RADIOLOGICAL SITUATION IN UKRAINE AFTER CHERNOBYL ACCIDENT AND OPTIMIZATION OF THE COUNTERMEASURES APPLICATION AT THE PRESENT STAGE by V. A. Kashparov, V. I. Yoschenko, Yu. O. Bondar, E. S. Tankatch

“…Taking into account the lately growing interest to radiation protection of not only human, but the environment as well, the results of the studies of frequency of the radiobiological effects of chronic irradiation to plantations of Scots pine in the Chernobyl exclusion zone depending on the levels of the dose to the trees' apical meristem are presented.…”
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Dosimetric Validation of Physical and Biological Indexes from the Dose-Volume Histogram for Evaluation of 3D-CRT and IMRT Techniques with VMAT Treatment Plan Techniques in Cervical... by Sougoumarane Dashnamoorthy, Ebenezar Jeyasingh, VINDHYAVASINI PANDEY, Karthick Rajamanickam, Sachin S Kotur, Durga Prasad Sahoo

“…Introduction:This study aims to investigate the Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP) of cervical cancer from Niemierko radiobiological model and compared with Lyman-Kutcher-Butcher (LKB) model’s effective volume parameter in three different planning techniques such as 3-Dimensional Conformal Radiation Therapy (3D-CRT), Intensity Modulated Radiotherapy (IMRT) and Volumetric Arc Therapy (VMAT).Material and Methods:Twenty patients were selected with Grade II and Grade III and the treatment plan was initially generated for 3D-CRT, IMRT and VMAT. …”
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A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs by Melissa McIntyre, Puthenparampil Wilson, Peter Gorayski, Eva Bezak

“…However, there is an increased sensitivity to uncertainties in patient motion/setup, proton range and radiobiological effect. Although recent efforts have mitigated some uncertainties, radiobiological effect remains unresolved due to a lack of clinical data for relevant endpoints. …”
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Evaluation of Proton-Induced Biomolecular Changes in MCF-10A Breast Cells by Means of FT-IR Microspectroscopy by Valerio Ricciardi, Marianna Portaccio, Maria Lasalvia, Francesco Paolo Cammarata, Pietro Pisciotta, Giuseppe Perna, Vito Capozzi, Giada Petringa, Lorenzo Manti, Maria Lepore

“…Hence, information about the biomolecular effects in exposed cells caused by such particles is needed to better realize the underlying radiobiological mechanisms and to improve this therapeutic strategy. …”
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Exploring the Physical and Biological Aspects of BNCT with a Carboranylmethylbenzo[<i>b</i>]acridone Compound in U87 Glioblastoma Cells by Ana Belchior, Ana Fernandes, Maxime Lamotte, Andreia Filipa Ferreira da Silva, Raquel S. G. R. Seixas, Artur M. S. Silva, Fernanda Marques

“…We performed a detailed study of the reactor dosimetry, cellular dose assessment, and radiobiological effects induced by BNCT in glioblastoma (GBM) cells. …”
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Why more needs to be known about RBE effects in modern radiotherapy. by Dale, R, Jones, B, Cárabe-Fernández, A

“…This is because the magnitude of RBE effect is not fixed for any one radiation/tissue combination but is subject to a number of other radiobiological influences. Such relationships may be quantified within the linear-quadratic radiobiological model, within which the associated concept of biologically effective dose (BED) provides a way of inter-comparing the overall biological impact of existing and projected treatments. …”

Thoron: Ignored and underestimated in the big shadow of radon - an example from China by Sebastian Feige, Jens Wiegand

“…This contribution suggests a need to conduct further radiobiological or epidemiological investigations.…”
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Quality of Radiosurgical Plans by Leksell Gamma Knife Perfexion in the Treatment of Meningioma: Comparison between two isodose lines (50% and 75%) by Gad Elbaz, Hedaya Hendam, Elsayed Alashkar, Hussein ABOUELGHEIT, Khairy Ereiba, Ehab Attalla

“…In current study, the aim was to compare two plans with different isodose line using radiobiological model, tumor control probability (TCP), normal tissue complication probability (NTCP) and plan’s physical indices.   …”
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Extreme Hypofractionation with SBRT in Localized Prostate Cancer by Maria Antonia Gómez-Aparicio, Jeannette Valero, Begoña Caballero, Rafael García, Ovidio Hernando-Requejo, Ángel Montero, Alfonso Gómez-Iturriaga, Thomas Zilli, Piet Ost, Fernando López-Campos, Felipe Couñago

“…Over the years, radiation delivery modalities have contributed to increased precision of treatment, employing radiobiological insights to shorten the overall treatment time, improving the control of the disease without increasing toxicities. …”
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On the 125th anniversary of the discovery of radioactivity: history of development and current state of regulation of the provision of the radiation safety of the public by G. G. Onischenko, I. K. Romanovich, O. A. Istorik, A. V. Vodovatov, A. M. Biblin, T. A. Kormanovskaya

“…It includes data on the history of discovery of the X-rays, radioactivity and development of the atomic industry in the USSR and in the world as well as the issues of evaluation of the radiobiological effects of the ionizing radiation on the human and history of the development of regulations. …”
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Liquid Biopsies for Molecular Biology-Based Radiotherapy by Erik S. Blomain, Everett J. Moding

“…Radiotherapy is one of the most commonly employed cancer treatment modalities, but radiobiologic approaches for personalizing therapy based on tumor biology and individual risks remain to be defined. …”
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