Sub-background radiation exposure at the LNGS underground laboratory: dosimetric characterization of the external and underground facilities by Marco Ampollini, Pasqualino Anello, Pasqualino Anello, Marco Balata, Emanuela Bortolin, Federico Chiarelli, Daniele Chiti, Maurizio Chiti, Cinzia De Angelis, Giulia D’Imperio, Raffaella Donghia, Giuseppe Esposito, Giuseppe Esposito, Francesco Ferella, Angelo Galante, Angelo Galante, Angelo Galante, Matthias Laubenstein, Patrizia Morciano, Patrizia Morciano, Stefano Nisi, Cristina Nuccetelli, Maria Cristina Quattrini, Maria Antonella Tabocchini, Claudia Tomei

“…Radiobiological studies conducted in Deep Underground Laboratories allow to improve the knowledge of the biological effects induced by ionizing radiation at low doses/dose rates. …”
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Advantages and robustness of partial VMAT with prone position for neoadjuvant rectal cancer evaluated by CBCT-based offline adaptive radiotherapy by Zhe Zhang, Shou Yu, Feng Peng, Zhibo Tan, Lei Zhang, Daming Li, Pengfei Yang, Zhaoming Peng, Xin Li, Chunfeng Fang, Yuenan Wang, Yajie Liu

“…Furthermore, the NTCP model was used to analyze its radiobiological side effects on the bladder and the bowel bag. …”
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Characterization of Intrinsic Radiation Sensitivity in a Diverse Panel of Normal, Cancerous and CRISPR-Modified Cell Lines by Francisco D. C. Guerra Liberal, Stephen J. McMahon

“…Despite the extensive amount of radiobiological data available, variability among different studies makes it very difficult to produce high-quality radiosensitivity biomarkers or predictive models. …”
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BUFFALOES' REPRODUCTIVE AND PRODUCTIVE TRAITS AS AFFECTED BY HEAT STRESS by Ibrahim F.M. Marai, A. A.M. Haeeb

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Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair by Osama Mohamad, Brock J. Sishc, Janapriya Saha, Arnold Pompos, Asal Rahimi, Michael D. Story, Anthony J. Davis, D.W. Nathan Kim

“…These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. …”
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METHODS OF ASSESSMENT OF THE RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS IN NEUTRON THERAPY by V. A. Lisin

“…Experimental and clinical studies as well as different mathematical and radiobiological models are used for assessing RBE. Research is conducted for neutron sources differing in the method of producing particles, energy and energy spectrum. …”
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Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy by Maria Grazia Ronga, Marco Cavallone, Annalisa Patriarca, Amelia Maia Leite, Pierre Loap, Vincent Favaudon, Gilles Créhange, Ludovic De Marzi

“…Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. …”
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Estimation of Cosmic-Ray-Induced Atmospheric Ionization and Radiation at Commercial Aviation Flight Altitudes by Panagiota Makrantoni, Anastasia Tezari, Argyris N. Stassinakis, Pavlos Paschalis, Maria Gerontidou, Pantelis Karaiskos, Alexandros G. Georgakilas, Helen Mavromichalaki, Ilya G. Usoskin, Norma Crosby, Mark Dierckxsens

“…Monte Carlo simulations were performed for the estimation quantities of radiobiological interest with the validated software DYASTIMA/DYASTIMA-R. …”
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Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma by Arvind Pandey, Veronica Vighetto, Nicola Di Marzio, Francesca Ferraro, Matteo Hirsch, Nicola Ferrante, Sankar Mitra, Alessandro Grattoni, Carly S. Filgueira

“…The presented data aids in the evaluation of the radiobiological response of Lewis lung carcinoma cells treated with gold nanoparticles.…”
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Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality by Amr M. H. Abdelhamid, Amr M. H. Abdelhamid, Amr M. H. Abdelhamid, Lu Jiang, Darren Zuro, An Liu, Srideshikan Sargur Madabushi, Hemendra Ghimire, Jeffrey Y. C. Wong, Simonetta Saldi, Christian Fulcheri, Claudio Zucchetti, Antonio Pierini, Ke Sheng, Cynthia Aristei, Susanta K. Hui

“…However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. …”
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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown by Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubin-de-Celis, Carsten Theiss, Veronika Matschke, Daniel Hoffmann, Verena Jendrossek, Johann Matschke

“…We combined the systematic collection of metabolic and radiobiological data from a panel of irradiated cancer cell lines with mathematical modeling and identified a common metabolic response with impact on the DSB repair kinetics, including a mitochondrial shutdown followed by compensatory glycolysis and resumption of mitochondrial function. …”
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Imaging DNA damage repair in vivo following 177Lu-DOTATATE therapy by O'Neill, E, Kersemans, V, Allen, P, Terry, S, Baguna Torres, J, Mosley, M, Smart, S, Lee, B, Falzone, N, Vallis, K, Konijnenberg, M, De Jong, M, Nonnekens, J, Cornelissen, B

“…Despite its frequent and successful use in the clinic, little or no radiobiologic considerations are made at the time of treatment planning or delivery. …”

Comparative study of the effects of different radiation qualities on normal human breast cells by Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda, Guido Hildebrandt

“…The risk for the development of secondary malignant neoplasms might be significantly increased due to exposure of healthy tissue outside of the target field to secondary neutrons, in particular in proton therapy. Thus far, the radiobiological effects of these neutrons and a comparison with photons on normal breast cells have not been sufficiently characterised. …”
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Reactive-Advective-Diffusive Models for the Growth of Gliomas Treated with Radiotherapy by Bruno da Silva Machado, Gustavo Benitez Alvarez, Diomar Cesar Lobão

“…The well-known linear-quadratic radiobiological model is used to describe cell death due to radiotherapy treatment. …”
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A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam by Arthur Bongrand, Charbel Koumeir, Daphnée Villoing, Arnaud Guertin, Ferid Haddad, Vincent Métivier, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Grégory Delpon, Sophie Chiavassa

“…Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. …”
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Towards Effective Targeted Alpha Therapy for Neuroendocrine Tumours: A Review by Paul M. D. Gape, Michael K. Schultz, Graeme J. Stasiuk, Samantha Y. A. Terry

“…The primary focus is on the transition from β-emitting radiopharmaceuticals to α-emitting agents in PRRT, offering a critical analysis of the radiobiological basis, clinical applications, and ongoing developments in Targeted Alpha Therapy (TAT). …”
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ADDITION TO THE QUASI-BIOLOGICAL MODEL OF RADIOGENIC CANCER MORBIDITY by A. Т. Gubin, V. A. Sakovich

“…However, since some of the assumptions of the model, including the new one, are not purely radiobiological, it would require analysis of a wider range of biological and cancer patterns.…”
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Non-targeted effects of photon and particle irradiation and the interaction with the immune system by Thomas Ernst Schmid, Gabriele eMulthoff

“…Due to their enhanced physical and radiobiological properties, high linear energy transfer (LET) radiation qualities are of special interest in tumor therapy. …”
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An analysis of the relationship between radiosensitivity and volume effects in tumor control probability modeling. by Buffa, F, Fenwick, J, Nahum, A

“…The dependence of local tumor control probability (tcp) on tumor volume is analyzed and discussed with the help of radiobiological modeling; in particular the impact of possible correlations between mean tumor radiosensitivity and tumor dimensions on the tcp volume dependence is explored. …”

Implications of respiratory motion for small animal image-guided radiotherapy by Hill, M, Vojnovic, B

“…Image-guided small animal irradiators have the potential to make a significant impact on facilitating the translation of radiobiological research into the clinic. To fully exploit the improved precision in dose delivery to the target/tumour while minimising dose to surrounding tissues, minimal positional error in the target is required. …”