Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review by Luca Tagliaferri, Valentina Lancellotta, Bruno Fionda, Monica Mangoni, Calogero Casà, Alessandro Di Stefani, Monica Maria Pagliara, Andrea D’Aviero, Giovanni Schinzari, Silvia Chiesa, Ciro Mazzarella, Stefania Manfrida, Giuseppe Ferdinando Colloca, Fabio Marazzi, Alessio Giuseppe Morganti, Maria Antonietta Blasi, Ketty Peris, Giampaolo Tortora, Vincenzo Valentini

“…We therefore provide the latest clinical evidence about radiobiological rationale, radiotherapy techniques, timing, and role both in advanced and systemic disease (with a special focus on ocular melanoma and brain, liver, and bone metastases) with a particular attention also in geriatric patients. …”
Get full text

Passive SOBP generation from a static proton pencil beam using 3D-printed range modulators for FLASH experiments by Felix Horst, Felix Horst, Elke Beyreuther, Elke Beyreuther, Elisabeth Bodenstein, Elisabeth Bodenstein, Sebastian Gantz, Diego Misseroni, Nicola M. Pugno, Nicola M. Pugno, Christoph Schuy, Francesco Tommasino, Francesco Tommasino, Uli Weber, Jörg Pawelke, Jörg Pawelke

“…In this work, a set of 3D-printed range modulators designed to generate spread out Bragg peaks (SOBPs) for radiobiological experiments at ultra-high dose rate at this beamline is described. …”
Get full text

Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer by Lisa Kerkhove, Febe Geirnaert, Amir Laraki Rifi, Ka Lun Law, Adrián Gutiérrez, Inge Oudaert, Cyril Corbet, Thierry Gevaert, Inès Dufait, Mark De Ridder

“…Taken together, this study is a stepping stone for applying SSZ as a radiosensitizer in the clinic and confirms that xCT in cancer cells is a valid radiobiological target.…”
Get full text

Is single fraction the future of stereotactic body radiation therapy (SBRT)? A critical appraisal of the current literature by M. Terlizzi, E. Limkin, N. Sellami, G. Louvel, P. Blanchard

“…However, both technical and radiobiological uncertainties remain. Experience from intracranial radiosurgery has shown that the size of the target, its proximity to organs at risk, tumor histology, and the volume of normal tissue irradiated are all determining factors in the choice of fractionation. …”
Get full text

Preoperative Radio(Chemo)Therapy in Breast Cancer: Time to Switch the Perspective? by Angel Montero, Raquel Ciérvide

“…Radiotherapy is also evolving toward a change in perspective: considering preoperative primary administration of radiotherapy may be useful in selected groups. Advances in radiobiological knowledge, together with technological improvements that are constantly being incorporated into clinical practice, support the administration of increasingly reliable, precise, and effective radiotherapy, as well as its safe combination with antitumor drugs or immunotherapy in the primary preoperative context. …”
Get full text

IMRT with the Use of Simultaneous Integrated Boost in Treatment of Head and Neck Cancer: Acute Toxicity Evaluation by Milan Vošmik, Karel Odrážka, Martin Doležel, Miloslava Vaculíková, Petr Kordač, Milan Zouhar, Jiří Petera, Jan Jansa, Zdeněk Zoul, Petr Paluska, Jan Vokurka

“…The results confirm that the irradiation according to our SIB-IMRT protocol is a therapy with acceptable toxicity and there is a space for radiobiological enhancement of this regimen by concurrent chemotherapy, e.g. weekly cisplatin.…”
Get full text

Hadron Therapy Achievements and Challenges: The CNAO Experience by Sandro Rossi

“…They are more precise than conventional X-rays and possess radiobiological characteristics suited for treating radio-resistant or inoperable tumours. …”
Get full text

On the Equivalence of the Biological Effect Induced by Irradiation of Clusters of Heavy Atom Nanoparticles and Homogeneous Heavy Atom-Water Mixtures by Balder Villagomez-Bernabe, José Ramos-Méndez, Frederick J. Currell

“…Our results demonstrate for the first time a simple route to intuit the radiobiological effects of clusters of nanoparticles through the consideration of an equivalent homogenous gold/water mixture. …”
Get full text

Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. by Schettino, G, Folkard, M, Prise, K, Vojnovic, B, Michael, B

“…The very fine focus achieved (< 0.25 micron radius spot) and the highly localised energy deposition of CK X rays (photoelectron range < 7 nm), represent unique tools to investigate modern radiobiological phenomena. Recent improvements have been directed to increase the dose rate (up to approximately 6 Gy.s-1 entrance dose averaged over a typical V79 cell) and to evaluate the possibility of using higher energy photons (AlK of 1.48 keV). …”

Results of a UK survey on methods for compensating for unscheduled treatment interruptions and errors in treatment delivery. by Dale, R, Jones, B, Sinclair, J, Comins, C, Antoniou, E

“…The desirability of providing training in the radiobiological methods pertaining to treatment compensation was raised by a number of respondents.…”

The Role of Ionizing Radiation for Diagnosis and Treatment against COVID-19: Evidence and Considerations by Marina Chalkia, Nikolaos-Achilleas Arkoudis, Emmanouil Maragkoudakis, Stamatis Rallis, Ioanna Tremi, Alexandros G. Georgakilas, Vassilis Kouloulias, Efstathios Efstathopoulos, Kalliopi Platoni

“…We identify details including the computed tomography (CT) scanning considerations, the radiobiological basis of IR anti-inflammatory effects, the supportive evidence for low dose radiation therapy (LDRT), and the risks of radiation-induced cancer and cardiac disease associated with LDRT. …”
Get full text

Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology by Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L. Simone

“…We will review the body’s natural circadian rhythms and clock gene-regulation while exploring preclinical and clinical evidence that implicates chronobiological disruptions in the etiology of breast cancer. We will discuss radiobiological principles and the circadian regulation of DNA damage responses. …”
Get full text

Enhance the Immune Checkpoint Inhibitors Efficacy with Radiotherapy Induced Immunogenic Cell Death: A Comprehensive Review and Latest Developments by Adrien Procureur, Audrey Simonaggio, Jean-Emmanuel Bibault, Stéphane Oudard, Yann-Alexandre Vano

“…Here, we will describe the biological and radiobiological rationale of the RT-induced ICD. We will then focus on the interest to combine RT and ICI, from bench to bedside, and summarize the clinical data existing with this combination. …”
Get full text

Role of Radiation Therapy in the Management of Renal Cell Cancer by Angel I. Blanco, Bin S. Teh, Robert J. Amato

“…Recent technological advances in radiation oncology have led to the clinical implementation of image-guided radiotherapy, allowing biologically potent doses to the tumors intra- and extra-cranially. As predicted by radiobiologic modeling, favorable outcomes have been observed with highly hypofractionated schemes modeled after the experience with intracranial stereotactic radiosurgery (SRS) for RCC brain metastases with reported local control rates averaging 85%. …”
Get full text

Low-Dose Radiation Therapy (LDRT) against Cancer and Inflammatory or Degenerative Diseases: Three Parallel Stories with a Common Molecular Mechanism Involving the Nucleoshuttling o... by Eymeric Le Reun, Nicolas Foray

“…Even if further investigations are needed to document and optimize LDRT, the apparent paradox of some radiobiological effects specific to low dose may be explained by the same mechanistic model based on the radiation-induced nucleoshuttling of the ATM kinase, a protein involved in various stress response pathways.…”
Get full text

The Performance of LiF:Mg-Ti for Proton Dosimetry within the Framework of the MoVe IT Project by Vittoria D’Avino, Francesco Tommasino, Stefano Lorentini, Giuseppe La Verde, Mariagabriella Pugliese

“…The results showed the good performance of the TLDs-100, proving their reliability for dose recordings in future radiobiological experiments planned within the MoVe IT context.…”
Get full text

Exploring breast and prostate cancer RNA-seq derived radiosensitivity with the Genomic Adjusted Radiation Dose (GARD) model by Ben Nolan, Brian O’Sullivan, Aaron Golden

“…Clear differences of clinical relevance in derived radiobiological properties between tumour and proximal normal tissues were evident for the breast cancer patient, whilst such differences across the prostate cancer cohort were more equivocal. …”
Get full text

Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy by Seth W. Streitmatter, Robert D. Stewart, Gregory Moffitt, Tatjana Jevremovic

“…The combined dosimetric and radiobiological model includes an analytical formulation that accounts for the type of neutron source, the tissue- or cancer-specific dose–response characteristics, and the microdistribution of boron. …”
Get full text

Treatment Planning in Intraoperative Radiation Therapy (IORT): Where Should We Go? by Carlo Cavedon, Renzo Mazzarotto

“…Other features implemented in TPSs should include deformable registration and capability of radiobiological planning, especially if unconventional irradiation schemes are used. …”
Get full text

Radiation Pneumonitis in Thoracic Cancer Patients: Multi-Center Voxel-Based Analysis by Giuseppe Palma, Serena Monti, Roberto Pacelli, Zhongxing Liao, Joseph O. Deasy, Radhe Mohan, Laura Cella

“…Connectograms showed that the dataset can support a radiobiological differentiation between the main heart and lung substructures.…”
Get full text