Intensity Modulated Radiotherapy with Carbon Ion Radiotherapy Boost for Acinic Cell Carcinoma of the Salivary Glands by Maximilian P. Schmid, Thomas Held, Kristin Lang, Klaus Herfarth, Juliane Hörner-Rieber, Semi B. Harrabi, Julius Moratin, Christian Freudlsperger, Karim Zaoui, Jürgen Debus, Sebastian Adeberg

“…All patients received a CIRT boost with 18–24 Gy radiobiologic effectiveness (RBE)-weighted dose in 3 Gy RBE-weighted dose per fraction followed by IMRT, with 50–54 Gy in 2 Gy per fraction. …”
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Gold Nanoparticles Enhancing Generation of ROS for Cs-137 Radiotherapy by Shiao-Wen Tsai, Chang-Yun Lo, Shang-Yang Yu, Fang-Hsin Chen, Hsiao-Chieh Huang, Lu-Kai Wang, Jiunn-Woei Liaw

“…In this paper, the radiobiological effects on A431 cells with uptake of 55-nm GNPs were studied to investigate the GNPs-enhanced production of ROS on these cells as irradiated by Cs-137 γ-ray. …”
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Spinal cord re-treatments using photon and proton based radiotherapy: LQ-derived tolerance doses by Jones, B, Hopewell, JW

“…</p> <p>A time-dependent model has been developed, which incorporates data from all published radiobiological experiments concerned with the in vivo re-irradiation of the spinal cord using photons. …”

A systematic review of health economic evaluations of proton beam therapy for adult cancer: Appraising methodology and quality by Jones, D, Smith, J, Mei, X, Hawkins, M, Maughan, T, van den Heuvel, F, Mee, T, Kirkby, K, Kirkby, N, Gray, A

“…Without randomised controlled trials to inform the comparative effectiveness of PBT, studies used either results from one-armed studies, or dose-response models derived from radiobiological and epidemiological studies of PBT. Costing methods varied widely. …”

Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer by Abdullah, Nurul Akmaryanti, Inman, Martyn, Moody, Christopher J., Storr, Sarah J., Martin, Stewart G.

“…This study provides important evidence of the roles of the thioredoxin system as an exploitable radiobiological target in breast cancer cells and highlights the potential therapeutic value of indolequinones as radiosensitisers.…”
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Relative biological effectiveness and dose-averaged linear energy transfer studies for proton therapy Monte Carlo treatment planning by Koh, Calvin Wei Yang

“…Despite the dosimetric advantage, physical and radiobiological uncertainties are a concern in Proton Therapy. …”
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The role of particle radiotherapy in the treatment of skull base tumors by Alberto Iannalfi, Giulia Riva, Lucia Ciccone, Ester Orlandi

“…Carbon ion therapy has peculiar and favorable radiobiological characteristics to overcome radioresistance features. …”
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Impact of per-cycle changes in spatial and temporal pattern of dose and biokinetics in neuroblastoma patients receiving 177Lu-DOTATATE by Malcolm, J

“…Subsequently, we applied these protocols on a single pretherapy Ga68-DOTATATE PET/CT and intra-therapy longitudinal SPECT/CT image sets acquired in six children with NBL after each cycle to understand the temporal change in physical dose and effective half life over a course of treatment in two anatomical and one functional region. The kinetics of radiobiological dose in the tumour was explored using parameters derived from in-vitro experiments. …”

Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers by Ana I. Lozano, Lidia Álvarez, Adrián García-Abenza, Carlos Guerra, Fábris Kossoski, Jaime Rosado, Francisco Blanco, Juan Carlos Oller, Mahmudul Hasan, Martin Centurion, Thorsten Weber, Daniel S. Slaughter, Deepthy M. Mootheril, Alexander Dorn, Sarvesh Kumar, Paulo Limão-Vieira, Rafael Colmenares, Gustavo García

“…Nonetheless, a proper evaluation of its radiosensitizing effects would require further radiobiological experiments.…”
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Out-of-Field Dose Measurement by TLD Dosimetry and Estimation of Radiation-Induced Secondary Cancer Risk of Thyroid and Breast from Head Radiotherapy by Shiva Rahbar Yazdi, Mohammad Hosein Zare, Mohammad Ali Broomand

“…Background: Radiation therapy, the most common form of cancer treatment, can result in late complications, such as secondary breast and thyroid cancers.Objective: This study aimed to evaluate the risk of secondary cancers using two radiobiological models of Excess Absolute Risk (EAR) and Excess Relative Risk (ERR) in patients with brain cancer undergoing radiotherapy for improved survival rates of cancer patients.Material and Methods: In this expository cross-sectional study, 45 patients under the age of 40 years underwent Whole Brain Radiotherapy (WBRT) using a compact accelerator in Shahid Ramezanzadeh Hospital, Yazd, Iran. …”
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Quantitative Correlations between Radiosensitivity Biomarkers Show That the ATM Protein Kinase Is Strongly Involved in the Radiotoxicities Observed after Radiotherapy by Eymeric Le Reun, Larry Bodgi, Adeline Granzotto, Laurène Sonzogni, Mélanie L. Ferlazzo, Joëlle Al-Choboq, Laura El-Nachef, Juliette Restier-Verlet, Elise Berthel, Clément Devic, Audrey Bouchet, Michel Bourguignon, Nicolas Foray

“…This is notably the case with the Common Terminology Criteria for Adverse Events (CTCAE). Few radiobiological studies have used the CTCAE scale as a clinical endpoint to evaluate the statistical robustness of the molecular and cellular predictive assays in the largest range of human radiosensitivity. …”
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Predicting stereotactic radiosurgery outcomes with multi-observer qualitative appearance labelling versus MRI radiomics by David A. DeVries, Terence Tang, Ali Albweady, Andrew Leung, Joanna Laba, Carol Johnson, Frank Lagerwaard, Jaap Zindler, George Hajdok, Aaron D. Ward

“…The qualitative appearance scoring enabled interpretation of the progression radiomics-based ML model, with necrotic BMs and a subset of heterogeneous BMs predicted as being at high-risk of post-SRS progression, in agreement with current radiobiological understanding. Our study’s results show that while radiomics-based SRS outcome models out-perform qualitative appearance analysis, qualitative appearance still provides critical insight into ML model operation.…”
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Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments by Alexander Zaboronok, Polina Khaptakhanova, Sergey Uspenskii, Raman Bekarevich, Ludmila Mechetina, Olga Volkova, Bryan J. Mathis, Vladimir Kanygin, Eiichi Ishikawa, Anna Kasatova, Dmitrii Kasatov, Ivan Shchudlo, Tatiana Sycheva, Sergey Taskaev, Akira Matsumura

“…The eBNPs significantly reduced colony-forming capacity in all studied cells during BNCT compared to BPA, verified by cell-survival curves fit to the linear-quadratic model and calculated radiobiological parameters, though the effect of both compounds differed depending on the cell line. …”
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Radio Sensitivity of the winter and spring barley varieties according to the morphological efect of low-dose gamma irradiation on the original seeds. by Е. А. Kazakova, Е. S. Makarenko, М. S. Podlutsky, A. A Dontsova, S. V. Bitarishvili, M. A. Lychenkova, I. V. Gorbatova, Е. G. Filippov, D. P. Dontsov, Т. V. Chizh, А. S. Snegirev, P. Yu. Volkova

“…The morphological analysis of the length and weight of roots and sprouts made it possible to establish the presence or absence of the stimulating irradiation effect on the studied indicators of the varieties and to conduct their subsequent ranking according to the value of the radiobiological effect. There have been identified the winter and spring barley varieties with different sensitivity to a dose of 20 Gy. …”
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A comparative and prospective study of two different radiation fractionation schedules with concurrent chemotherapy in locally advanced head-and-neck squamous cell carcinoma by Chayan Roy, Linkon Biswas, Arabinda Roy, Shyam Sharma, Firdoushi Khatun, Srikrishna Mandal

“…Background: Accelerated fractionation radiotherapy has radiobiological advantage of preventing accelerated tumor repopulation and logistic advantage of treating more patients than conventionally fractionated radiotherapy because of its relatively shorter treatment duration. …”
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Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity &amp; in vivo b... by Esraa Taha, Samia A. Nour, Wael Mamdouh, Adli A. Selim, Mohamed M. Swidan, Ahmed B. Ibrahim, Marianne J. Naguib

“…In vivo biodistribution in mice was evaluated by a radiobiological technique using radioiodinated zopiclone([131I]iodo-ZP). …”
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Daily irradiation versus irradiation at two- to three-day intervals in stereotactic radiotherapy for patients with 1-5 brain metastases: study protocol for a multicenter open-label... by Natsuo Tomita, Hiromichi Ishiyama, Chiyoko Makita, Yukihiko Ohshima, Aiko Nagai, Fumiya Baba, Mayu Kuno, Shinya Otsuka, Takuhito Kondo, Chikao Sugie, Tatsuya Kawai, Taiki Takaoka, Dai Okazaki, Akira Torii, Masanari Niwa, Nozomi Kita, Seiya Takano, Shogo Kawakami, Masayuki Matsuo, Tomoyasu Kumano, Makoto Ito, Sou Adachi, Souichiro Abe, Takayuki Murao, Akio Hiwatashi

“…Abstract Background Radiobiological daily changes within tumors are considered to be quite different between stereotactic radiotherapy (SRT) (e.g., 50 Gy in 4 fractions) and conventional radiotherapy (e.g., 60 Gy in 30 fractions). …”
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Estimation of lymphocyte radiation doses after the ingestion of radionuclides of different tropicity by E. I. Tolstykh, M. O. Degteva, A. V. Akleyev

“…Assessment of the lymphocyte doses is relevant for solving a number of radiobiological problems, including the risk assessment of hemoblastosis (leukemia, multiple myeloma, lymphoma etc.), as well as the use of circulating lymphocytes as “natural biodosimeters”. …”
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Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells by Nelly Babayan, Natalia Vorobyeva, Bagrat Grigoryan, Anna Grekhova, Margarita Pustovalova, Sofya Rodneva, Yuriy Fedotov, Gohar Tsakanova, Rouben Aroutiounian, Andreyan Osipov

“…Laser-driven accelerators allow to generate ultrashort (from femto- to picoseconds) high peak dose-rate (up to tens of GGy/s) accelerated particle beams. However, the radiobiological effects of ultrashort pulsed irradiation are still poorly studied. …”
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Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Pro... by Darren M. C. Poon, Daisy Lam, Kenneth C. W. Wong, Cheuk-Man Chu, Michael Cheung, Frankie Mo, Joyce Suen, Chi-Fai Ng, Anthony T. C. Chan

“…Background: Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). …”
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