Assessment of Radiation-Induced Bladder and Bowel Cancer Risks after Conventionally and Hypo-Fractionated Radiotherapy for the Preoperative Management of Rectal Carcinoma by Ekaterini Matsali, Eleftherios P. Pappas, Efrossyni Lyraraki, Georgia Lymperopoulou, Michalis Mazonakis, Pantelis Karaiskos

“…This study aims to dosimetrically and radiobiologically compare all available approaches, with emphasis on the risk of radiation-induced second cancer to the bladder and bowel. …”
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Combining a noble gas with radiotherapy: glutamate receptor antagonist xenon may act as a radiosensitizer in glioblastoma by Thomas Büttner, Marielena K. E. Maerevoet, Frank A. Giordano, Marlon R. Veldwijk, Carsten Herskind, Arne Mathias Ruder

“…Methods We designed a diffusion-based system to perform the colony formation assay (CFA), the radiobiological gold standard, under xenon exposure. Stable and reproducible gas atmosphere was validated with oxygen and carbon dioxide as tracer gases. …”
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Absorbed dose calculation for a realistic CT-derived mouse phantom irradiated with a standard Cs-137 cell irradiator using a Monte Carlo method. by Amir Entezam, Andrew Fielding, David Bradley, Davide Fontanarosa

“…The CT derived MC mouse model presented here is a useful tool for tumour dose verifications as well as investigating the doses to normal tissue (in out of field) for preclinical radiobiological research.…”
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Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts by Suzanne Fischer, David Creytens, Stefanie Gijsels, Benedicte Descamps, Lore Lapeire, An Hendrix, Gwen Sys, Olivier De Wever

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Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy by Eymeric Le Reun, Adeline Granzotto, Adeline Pêtre, Larry Bodgi, Guillaume Beldjoudi, Thomas Lacornerie, Véronique Vallet, Audrey Bouchet, Joëlle Al-Choboq, Michel Bourguignon, Juliette Thariat, Jean Bourhis, Eric Lartigau, Nicolas Foray

“…While the benefits of hypofractionated SBRT have been attributed to additional vascular, immune effects, or specific cell deaths, a radiobiological and mechanistic model is still needed. …”
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Validation of the relative biological effectiveness of active-energy scanning carbon-ion radiotherapy on a commercial treatment planning system with a microdosimetic kinetic model by Weiwei Wang, Wei Sun, Hao Shen, Jingfang Zhao

“…Methods The Ray-MKM was benchmarked using a spread-out Bragg-peak (SOBP) plan, which was suggested in literature from the National Institute of Radiobiological Science (NIRS) in Japan. The residual RBE differences from the MKM at NIRS (NIRS-MKM) were derived using several SOBP plans with different ranges, SOBP widths, and prescriptions. …”
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Dosimetric comparison of standard three-dimensional conformal radiotherapy followed by intensity-modulated radiotherapy boost schedule (sequential IMRT plan) with simultaneous inte... by A Bansal, R Kapoor, S K Singh, N Kumar, A S Oinam, S C Sharma

“…Aims: Dosimeteric and radiobiological comparison of two radiation schedules in localized carcinoma prostate: Standard Three-Dimensional Conformal Radiotherapy (3DCRT) followed by Intensity Modulated Radiotherapy (IMRT) boost (sequential-IMRT) with Simultaneous Integrated Boost IMRT (SIB-IMRT). …”
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On Prediction of Cardio-Pulmonary Complications during Hypofractionated versus Conventional Fractionated Regimens of Left Breast Radiation Therapy Using Monte Carlo and Collapsed C... by Sepideh Omidvar, kamal mostafanezhad, Ahad Zeinali

“…Normal tissue complication probability (NTCP) and tumor control probability (TCP) values for each regimen using radiobiological models were calculated via Monte Carlo (MC) and Collapsed Cone Convolution (CCC) algorithms. …”
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Effects of Radiation Intensity, Mineral Matrix, and Pre-Irradiation on the Bacterial Resistance to Gamma Irradiation under Low Temperature Conditions by Vladimir S. Cheptsov, Andrey A. Belov, Elena A. Vorobyova, Anatoli K. Pavlov, Vladimir N. Lomasov

“…Considering the low intensity of radiation on various space objects in comparison with radiobiological experiments, this suggests a longer preservation of the viable microorganisms outside the Earth than is commonly believed. …”
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First Strike personalized predictive radioiodine prescription for inoperable metastatic differentiated thyroid cancer by Yung Hsiang Kao

“…A Standard Female with oligometastasis and good urine output without diffuse lung metastasis is expected to safely tolerate 8.03 GBq of radioiodine as the First Strike.Conclusion: This predictive method will help institutions rationalise the First Strike prescription based on radiobiologically sound principles, personalised to individual circumstances.…”
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Assessing the mechanistic synergy between cancer virotherapy and external beam radiation by Pokrovska, T

“…<p>One of the core radiobiological features determining response to fractionated treatment is repair of ionising radiation-mediated damage. …”

Secondary Cancer Risk of Radiotherapy and Imaging Examination for Two Different Malignancies in One Patient by Mohammad Hosein Zare, Hamidreaza Masjedi, Fateme Tabatabaee, Shiva Rahbar Yazdi, Masoud Shabani, Mohammad Ali Broomand

“…To evaluate the cancer risk, radiobiological models for Excess Absolute Risk (EAR), as well as Excess Relative Risk (ERR) published by the Committee on the Biological Effects of Ionizing Radiation (BEIR) in report VII, were implemented. …”
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Long-term Outcomes from Proton Therapy for Sinonasal Cancers by Roi Dagan, MD, MS, Haruka Uezono, MD, Curtis Bryant, MD, Adam L. Holtzman, MD, Christopher G. Morris, MS, William M. Mendenhall, MD

“…Most (91%) received high-dose (median, 73.6 Gy radiobiological equivalent [GyRBE]; 84% > 70 GyRBE) passive-scatter proton therapy using accelerated hyperfractionation (1.2 GyRBE twice daily) and concurrent chemotherapy (70%). …”
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The Effects of Particle LET and Fluence on the Complexity and Frequency of Clustered DNA Damage by Mohammad Rezaee, Amitava Adhikary

“…Quantification of this specific type of damage as a function of radiation parameters such as LET, dose rate, dose, and particle type can be informative for the prediction of biological outcome in radiobiological studies. This study investigated the induction and complexity of clustered DNA damage for three different types of particles at an LET range of 0.5–250 keV/µm. …”
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PET imaging of DNA damage using (89)Zr-labelled anti-γH2AX-TAT immunoconjugates. by Knight, J, Topping, C, Mosley, M, Kersemans, V, Falzone, N, Fernández-Varea, J, Cornelissen, B

“…Since (89)Zr emits ionizing radiation, detailed radiobiological measurements were included to ensure (89)Zr-anti-γH2AX-TAT itself does not cause any additional DSBs. …”

Mathematical modeling of radiotherapy cancer treatment using caputo fractional derivative by Farayola, M. F., Shafie, S., Siam, F. M., Khan, I.

“…The model takes into consideration two important radiobiological factors, which are repair and repopulation of cells. …”

A Prospective Randomised Study of Comparison between Conventional and Accelerated Fractionation Radiotherapy in Treatment of Head and Neck Cancers by M Hemanth, BV Subramanian, Pranabandhu Das, J Swapna, AY Lakshmi

“…Conclusion: Accelerated fractionation can be considered as an alternative treatment strategy to conventional fractionation which is radiobiologically superior and is beneficial for centers where the patient load is much higher than the facility available.…”
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Gamma Knife Radiosurgery for Cushing’s Disease: Evaluation of Biological Effective Dose from a Single-Center Experience by Yuan Gao, Mengqi Wang, Yang Wu, Hao Deng, Yangyang Xu, Yan Ren, Chun Wang, Wei Wang

“…Biological effective dose (BED) is a radiobiological parameter with time correction, considering the cellular deoxyribonucleic acid repairment. …”
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Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience by G. Brandon Gunn, MD, Adam S. Garden, MD, Rong Ye, MSc, Noveen Ausat, BA, Kristina R. Dahlstrom, PhD, William H. Morrison, MD, C. David Fuller, MD, PhD, Jack Phan, MD, PhD, Jay P. Reddy, MD, PhD, Shalin J. Shah, MD, Lauren L. Mayo, MD, Stephen G. Chun, MD, Gregory M. Chronowski, MD, Amy C. Moreno, MD, Jeffery N. Myers, MD, PhD, Ehab Y. Hanna, MD, Bita Esmaeli, MD, Maura L. Gillison, MD, PhD, Renata Ferrarotto, MD, Katherine A. Hutcheson, PhD, Mark S. Chambers, DMD, MS, Lawrence E. Ginsberg, MD, Adel K. El-Naggar, MD, PhD, David I. Rosenthal, MD, Xiaorong Ronald Zhu, PhD, Steven J. Frank, MD

“…Median dose was 66 Gy (radiobiological equivalent). Regarding systemic therapy, 43% had received concurrent (n = 244), 3% induction (n = 19), and 15% (n = 86) had both. …”
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Stereotactic Body Radiotherapy and Immunotherapy for Older Patients with Oligometastases: A Proposed Paradigm by the International Geriatric Radiotherapy Group by Nam P. Nguyen, Ahmed Ali, Vincent Vinh-Hung, Olena Gorobets, Alexander Chi, Thandeka Mazibuko, Natália Migliore, Maria Vasileiou, David Lehrman, Mohammad Mohammadianpanah, Seyed Alireza Javadinia, Gokoulakrichenane Loganadane, Trinanjan Basu, Satya Bose, Ulf Karlsson, Huan Giap

“…We propose a protocol combining SBRT to achieve a minimum radiobiologic equivalent dose around 59.5 Gy to all tumor sites if feasible, followed four to six weeks later by CPI for those cancer patients with oligometastases. …”
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