Dosimetric quantities and cell survival for spatially fractionated radiation therapy by Mabroor Ahmed, Mabroor Ahmed, Mabroor Ahmed, Sandra Bicher, Sandra Bicher, Robert D. Stewart, Stefan Bartzsch, Stefan Bartzsch, Thomas E. Schmid, Thomas E. Schmid, Stephanie E. Combs, Stephanie E. Combs, Juergen Meyer

“…We hypothesize that to evaluate clinical effectiveness and understand fundamental biological mechanisms, radiobiological rather than physical dose quantities should be utilized for comparisons. …”
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ALA-RDT in GBM: protocol of the phase I/II dose escalation trial of radiodynamic therapy with 5-Aminolevulinic acid in patients with recurrent glioblastoma by Niklas Benedikt Pepper, Hans Theodor Eich, Michael Müther, Michael Oertel, Stephan Rehn, Dorothee Cäcilia Spille, Walter Stummer

“…Additionally, 5-ALA metabolites and radiobiological markers will be analysed throughout the course of therapy and tissue effects after neoadjuvant treatment will be determined in resected tissue. …”
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Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats by Milomir O. Simovic, Michael J. Falabella, Tuan D. Le, Jurandir J. DalleLucca, Yansong Li

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Dosimetric difference analysis of various bolus regimens in post-mastectomy intensity modulated radiotherapy by NIU Ruijun, QI Yuexiao, TAO Na, GUO Qing, WEI Xiyi, GAO Liying, TAO Fali, LIU Tingting, CHENG Jianqiang, WEI Shihong

“…Regarding the skin radiobiological evaluation, the NTCP of the 5_mm all bolus group was prominently better than other groups and was statistically significant (p < 0.05). …”
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Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy by Mark W. Dewhirst, James R. Oleson, John Kirkpatrick, Timothy W. Secomb

“…An important question, therefore, is whether HT induced reoxygenation occurs in the clinic that is of radiobiological significance. In this review, we will discuss the influence of thermal history on reoxygenation in both human and canine cancers treated with thermoradiotherapy. …”
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Commissioning and dosimetric results of an indigenously developed intra-vaginal template for interstitial plus intracavitary high dose rate image-guided brachytherapy of advanced c... by Venkatesan Kaliyaperumal, Susovan Banerjee, Tejinder Kataria, Susan K Abraham, Dayanithi Kamaraj, Singaravelu Tamilselvan, Deepak Gupta, Shyam Singh Bisht, Kushal Narang, Sorun Shishak

“…The IGBT plans were evaluated based on EQD2 of target coverage i.e., dose received by 98% (D98%_HRCTV), 90% (D90%_HRCTV), and 50% (D50%_HRCTV) volume of HRCTV, and dose received by 2 cc (D2cc) and 0.1 cc (D0.1cc) of OAR using linear quadratic (LQ) radiobiological model. Results: The autoradiographic in radiochromic film shows that the distance between the needle tip and the middle of the source position is 6 mm. …”
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Radiotherapy cancer treatment model with fractional derivative coupled with linear-quadratic model by Farayola, Musiliu Folarin

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PET imaging of DNA damage using 89Zr-labelled anti-γH2AX-TAT immunoconjugates by Knight, J, Topping, C, Mosley, M, Kersemans, V, Falzone, N, Falzone, N, Fernández-Varea, J, Cornelissen, B

“…Since ⁸⁹Zr emits ionizing radiation, detailed radiobiological measurements were included to ensure ⁸⁹Zr-anti-γH2AX-TAT itself does not cause any additional DSBs. …”

Radiotherapy cancer treatment model with fractional derivative coupled with linear-quadratic model by Farayola, Musiliu Folarin

“…The model takes two important radiobiological factors into consideration, which are repair and repopulation of cells. …”
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Thoughts, perceptions and concerns of coastal residents regarding the discharge of tritium-containing treated water from the Fukushima Daiichi Nuclear Power Plant into the Pacific... by Varsha Hande, Makiko Orita, Hitomi Matsunaga, Yuya Kashiwazaki, Xu Xiao, Thierry Schneider, Jacques Lochard, Yasuyuki Taira, Noboru Takamura

“…Abstract Background As a part of the decontamination process after the Fukushima Daiichi Nuclear Power Plant accident of 2011, 1.32 million tonnes of tritium-containing water will be discharged from the power plant into the Pacific Ocean. Although radiobiological impacts of the treated water discharge on the public and the environment were reported to be minimal, Tomioka and Okuma locals expressed unease regarding the long-term recovery of their towns, which are economically dependent on the agricultural, fishery, and tourism sectors. …”
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Long-Term Cultured Human Glioblastoma Multiforme Cells Demonstrate Increased Radiosensitivity and Senescence-Associated Secretory Phenotype in Response to Irradiation by Lina Alhaddad, Zain Nofal, Margarita Pustovalova, Andreyan N. Osipov, Sergey Leonov

“…For this purpose, we compared radiobiological effects of X-ray exposure on two isogenic human U87 cell lines: U87L, minimally cultured cells (<15 passages after obtaining from the ATCC) and U87H, long-term cultured cells (>3 years of continuous culturing after obtaining from the ATCC). …”
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Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach by Elettra Valentina Bellinzona, Leszek Grzanka, Andrea Attili, Francesco Tommasino, Thomas Friedrich, Michael Krämer, Michael Scholz, Giuseppe Battistoni, Alessia Embriaco, Davide Chiappara, Giuseppe A. P. Cirrone, Giada Petringa, Marco Durante, Emanuele Scifoni

“…Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. …”
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Using the photon isoeffective dose formalism to compare and combine BNCT and CIRT in a head and neck tumour by Ian Postuma, Chiara Magni, Barbara Marcaccio, Setareh Fatemi, Valerio Vercesi, Mario Ciocca, Giuseppe Magro, Ester Orlandi, Barbara Vischioni, Sara Ronchi, Yuan-Hao Liu, Yang Han, Changran Geng, Sara Josefina González, Silva Bortolussi

“…The example allows presenting different dosimetrical and radiobiological quantities and drawing conclusions on the potential of BNCT stemming on the clinical result of the CIRT. …”
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Comparison of Heart and Lung Doses According to Tumor Bed Boost Techniques in Early-Stage Left-Sided Breast Cancer: Simultaneous Integrated Boost versus Sequential Boost by Myungsoo Kim, Nam Kwon Lee, Suk Lee, Jinho Hwang

“…Furthermore, a large radiation dose per day may be advantageous, considering the radiobiologic aspects of breast cancer. Long-term follow-up data are needed to determine whether the dosimetric advantages of the WBI-SIB plan can lead to clinically improved patient outcomes and reduced late side effects.…”
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Dosimetric Evaluation of PSMA PET-Delineated Dominant Intraprostatic Lesion Simultaneous Infield Boosts by Christopher D. Goodman, MD, Hatim Fakir, PhD, Stephen Pautler, MD, Joseph Chin, MD, Glenn S. Bauman, MD

“…Dose escalation to the dominant lesion is a proposed strategy to increase tumor control. We applied radiobiological modeling to evaluate the dosimetric feasibility and benefit of dominant intraprostatic lesion simultaneous in-field boosts (DIL-SIB) to the gross tumor volume (GTV), defined using a novel molecular positron emission tomography (PET) probe (18F-DCFPyL) directed against prostate specific membrane antigen (PSMA). …”
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An external perpendicular magnetic field does not influence survival and DNA damage after proton and carbon ion irradiation in human cancer cells by Sylvia Kerschbaum-Gruber, Fatima Padilla-Cabal, Elisabeth Mara, Birgit Lohberger, Dietmar Georg, Hermann Fuchs

“…Background and purpose: Magnetic field effects on the radiobiological effectiveness during treatment of magnetic resonance (MRI) guided particle therapy are being debated. …”
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Traumatized triad of complementopathy, endotheliopathy, and coagulopathy ˗ Impact on clinical outcomes in severe polytrauma patients by Zhangsheng Yang, Tuan D. Le, Milomir O. Simovic, Milomir O. Simovic, Bin Liu, Tamara L. Fraker, Tamara L. Fraker, Tomas S. Cancio, Andrew P. Cap, Charles E. Wade, Jurandir J. DalleLucca, Yansong Li, Yansong Li

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Refining the evolutionary tree of the horse Y chromosome by Elif Bozlak, Lara Radovic, Viktoria Remer, Doris Rigler, Lucy Allen, Gottfried Brem, Gabrielle Stalder, Caitlin Castaneda, Gus Cothran, Terje Raudsepp, Yu Okuda, Kyaw Kyaw Moe, Hla Hla Moe, Bounthavone Kounnavongsa, Soukanh Keonouchanh, Nguyen Huu Van, Van Hai Vu, Manoj Kumar Shah, Masahide Nishibori, Polat Kazymbet, Meirat Bakhtin, Asankadyr Zhunushov, Ripon Chandra Paul, Bumbein Dashnyam, Ken Nozawa, Saria Almarzook, Gudrun A. Brockmann, Monika Reissmann, Douglas F. Antczak, Donald C. Miller, Raheleh Sadeghi, Ines von Butler-Wemken, Nikos Kostaras, Haige Han, Dugarjaviin Manglai, Abdugani Abdurasulov, Boldbaatar Sukhbaatar, Katarzyna Ropka-Molik, Monika Stefaniuk-Szmukier, Maria Susana Lopes, Artur da Câmara Machado, Valery V. Kalashnikov, Liliya Kalinkova, Alexander M. Zaitev, Miguel Novoa‐Bravo, Gabriella Lindgren, Samantha Brooks, Laura Patterson Rosa, Ludovic Orlando, Rytis Juras, Tetsuo Kunieda, Barbara Wallner

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One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: the FAST-Forward phase III RCT by Adrian Murray Brunt, Joanne S Haviland, Duncan A Wheatley, Mark A Sydenham, David J Bloomfield, Charlie Chan, Suzy Cleator, Charlotte E Coles, Ellen Donovan, Helen Fleming, David Glynn, Andrew Goodman, Susan Griffin, Penelope Hopwood, Anna M Kirby, Cliona C Kirwan, Zohal Nabi, Jaymini Patel, Elinor Sawyer, Navita Somaiah, Isabel Syndikus, Karen Venables, John R Yarnold, Judith M Bliss

“…The first results of the FAST trial, subsequently confirmed with the 10-year results, identified a 5-fraction schedule estimated to be radiobiologically equivalent to the 25-fraction standard in terms of late NTE. …”
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