Revertant Mosaicism in Genodermatoses: Natural Gene Therapy Right before Your Eyes by Peter C. van den Akker, Maria C. Bolling, Anna M. G. Pasmooij

“…This has shifted the paradigm from RM being an extraordinary phenomenon to it being something that every physician working in the field of genodermatoses should be looking for in every patient. It has also raised hope for new treatment options in patients with genodermatoses. …”
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Quantification of HLA class I molecules on renal cell carcinoma using Edman degradation by Stenzl Arnulf, Klingel Karin, Hennenlotter Jörg, Stickel Natalie, Stickel Juliane S, Rammensee Hans-Georg, Stevanović Stefan

“…</p> <p>Conclusion</p> <p>Edman degradation allows the direct quantitative comparison of HLA class I protein expression by tumor or normal tissue and metastases of RCC patients. Our results raise hopes for improving the success and effectiveness of future immunotherapeutic concepts for metastatic RCC.…”
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Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine by Alexander R. Harris, Mary Jean Walker, Frederic Gilbert

“…The use of donor or animal tissue raises many well-known issues, including limited tissue availability, the possibility of rejection and patient infection. Stem cell therapy raised hope of overcoming these issues, but created new risks including tumour formation and limited benefit if the desired target tissue does not form. …”
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An Efficient Post-Quantum Attribute-Based Encryption Scheme Based on Rank Metric Codes for Cloud Computing by Vahid Yousefipoor, Taraneh Eghlidos

“…On the other hand, in recent years, extensive advances have been made in quantum processors, which have raised hopes of solving certain mathematical problems includes factoring integers and computing discrete logarithms of large numbers. …”
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Expression of TRAIL and TRAIL receptors in normal and malignant tissues. by Daniels, R, Turley, H, Kimberley, F, Liu, X, Mongkolsapaya, J, Ch'En, P, Xu, X, Jin, B, Pezzella, F, Screaton, G

“…Tumour cells were initially found to have increased sensitivity to TRAIL compared with normal cells, raising hopes that TRAIL would prove useful as an anti-tumor agent. …”

Targeting TOPK 1 sensitises tumour cells to radiation-induced damage by enhancing replication stress by Herbert, K, Puliyadi, R, Prevo, R, Rodriguez Berriguete, G, Ryan, A, Ramadan, K, Higgins, G

“…As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development of targeted therapeutics. …”

Multifunctional silica-coated iron oxide nanoparticles: a facile four-in-one system for in situ study of neural stem cell harvesting. by Peng, Y, Lui, C, Lin, T, Chang, C, Chou, P, Yung, K, Tsang, S

“…The extraction, modification and re-application of NSCs have thus attracted much attention and raised hopes for novel neural stem cell therapies and regenerative medicine. …”

Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome by Patrice X. Petit, Hector Ardilla-Osorio, Lucile Penalvia, Nathan E. Rainey

“…Our findings provide some additional insights into mitochondrial dysfunction associated with Barth syndrome, but also show that mitophagy inhibition is concomitant with apoptosis dysfunction through the inability of abnormal mitochondrial cardiolipin to assume its role in cytoplasmic signal transduction. Our work raises hope that pharmacological manipulation of the mitophagic pathway together with mitochondrially targeted antioxidants may provide new insights leading to promising treatment for these highly lethal conditions.…”
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MSC Based Therapies to Prevent or Treat BPD—A Narrative Review on Advances and Ongoing Challenges by Maurizio J. Goetz, Sarah Kremer, Judith Behnke, Birte Staude, Tayyab Shahzad, Lena Holzfurtner, Cho-Ming Chao, Rory E. Morty, Saverio Bellusci, Harald Ehrhardt

“…Preclinical studies, mainly performed in rodents, raise hopes that there will be finally a broadly acting, efficient therapy at hand to prevent or treat BPD. …”
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Recent Advances with Precision Medicine Treatment for Breast Cancer including Triple-Negative Sub-Type by Md Abdus Subhan, Farzana Parveen, Hassan Shah, Satya Siva Kishan Yalamarty, Janaína Artem Ataide, Valdimir P. Torchilin

“…The development of next-generation sequencing technologies has raised hopes for precision-medicine treatment strategies in breast cancer (BC) and triple-negative breast cancer (TNBC). …”
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Active Nanointerfaces Based on Enzyme Carbonic Anhydrase and Metal–Organic Framework for Carbon Dioxide Reduction by Qian Liu, Xinwei Bai, Huy Pham, Jianli Hu, Cerasela Zoica Dinu

“…Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging and efficient strategies that could reduce greenhouse emission and the footprint of anthropogenic activities. …”
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Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance by Ioana-Andreea Lungu, Octavia-Laura Moldovan, Victoria Biriș, Aura Rusu

“…Many fluoroquinolone hybrids are in various phases of clinical trials, raising hopes that new antibacterial agents will be approved shortly.…”
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The variability of palm print ridge density among Egyptians regarding distribution and sex discrimination by Nazih Ramadan, Asmaa Mohamed Sayed Ahmed

“…CONCLUSION: The current study raises hope for the usage of palm print a newly added tool for sex identification in the forensic field, thus decreasing suspicion by fifty percent.…”
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Role and Therapeutic Potential of Melatonin in the Central Nervous System and Cancers by Sangiliyandi Gurunathan, Min-Hee Kang, Jin-Hoi Kim

“…These characteristics raise hopes that it could be used in humans for central nervous system (CNS)-related disorders. …”
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The role of information communication technology (ICT) towards universal health coverage: the first steps of a telemedicine project in Ethiopia by Fassil Shiferaw, Maria Zolfo

“…Recently, the application of information communication technology (ICT) to health care delivery and the use of telemedicine have raised hopes.Objective: This paper analyzes the challenges, failures and successes encountered in setting-up and implementing a telemedicine program in Ethiopia and provides possible recommendations for developing telemedicine strategies in countries with limited resources.Design: Ten sites in Ethiopia were selected to participate in this pilot between 2004 and 2006 and twenty physicians, two per site, were trained in the use of a store and forward telemedicine system, using a dial-up internet connection. …”
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Embedded machine learners for classifying EEG patterns in a wearable device for brain-computer interface by Lim, Kok Meng

“…With the advent of brain computer interface (BCI), it raises hope in helping this group of people to perform simple tasks which were once thought overwhelmingly not possible. …”
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Characterising neural plasticity at the single patient level using connectivity fingerprints by Voets, N, Parker Jones, O, Mars, R, Adcock, J, Stacey, R, Apostolopoulos, V, Plaha, P

“…The occurrence of wide-scale neuroplasticity in the injured human brain raises hopes for biomarkers to guide personalised treatment. …”

Skilful probabilistic medium‐range precipitation and temperature forecasts over Vietnam for the development of a future dengue early warning system by Main, L, Sparrow, S, Weisheimer, A, Wright, M

“…This forecast reliability demonstrates that meteorological input data based on ECMWF ensemble forecasts would add appreciably more value to the development of a future dengue early warning system compared to reference forecasts like climatology or persistence. These results raise hope for further exploration of predictive skill for relevant meteorological variables, particularly focused on their downscaling to produce district‐level epidemiological forecasts for urban areas where dengue is most prevalent.…”

Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells by Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Vijay Kumar Ulaganathan, Annika Herrmann, Nefertiti Elnikhely, Chitra Thakur, Zhiguang Xiao, Pjotr Knyazev, Beyhan Ataseven, Rajkumar Savai, Ernst Wagner, Andreas Roidl

“…The discovery of the cancer stem cell (CSC)–specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and mesenchymal cancer cells. …”
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Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme by Andreas Hahn, Yuji Sato, Toshiaki Ikeda, Hiroyuki Sonoda, Mathias Schmidt, Charlotte Pfrimmer, Ruben J. Boado, William M. Pardridge

“…Monitoring of side effects raised no unacceptable or unexpected safety concerns.Observed improvement of life quality related to ameliorated epilepsy control raises hope that further robust clinical trials including patients in earlier stages of disease will show positive results.…”
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