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Farnesyltransferase inhibitors.
Published 2001“…The targeting of ras through the inhibition of Ras protein farnesylation is one new cancer treatment strategy under clinical evaluation. …”
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The metabolic landscape of RAS-driven cancers from biology to therapy
Published 2022“…Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. …”
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23
Control of Ras/Erk signalling pathway by the brahma chromatin-remodelling complex.
Published 2011“…Analysis of components in this pathway at both the transcriptional and protein levels following overexpression of wild-type Brahma in Drosophila S2 cells, demonstrated that Brahma may affect EGFR mRNA expression and Ras protein level. In addition, previous studies suggest that Brahma activity is regulated through phosphorylation by kinases, including Erk and cyclin E/CDK 2. …”
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Final Year Project (FYP) -
24
Small-Molecule Inhibitors and Degraders Targeting KRAS-Driven Cancers
Published 2021-11-01“…In particular, considerable efforts have been made to treat KRAS-induced cancers by directly and indirectly controlling the activity of KRAS. However, the RAS protein is still one of the most prominent targets for drugs in cancer treatment. …”
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25
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
Published 2018“…The RAS biosensors represent a useful tool to investigate and characterize the potency of anti-RAS inhibitors in cells and more generally any RAS protein-protein interaction (PPI) in cells.…”
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Recent Developments in Targeting RAS Downstream Effectors for RAS-Driven Cancer Therapy
Published 2021-12-01“…Aberrant activity of oncogenic rat sarcoma virus (RAS) protein promotes tumor growth and progression. RAS-driven cancers comprise more than 30% of all human cancers and are refractory to frontline treatment strategies. …”
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27
Structural Mechanisms and Drug Discovery Prospects of Rho GTPases
Published 2016-06-01“…However, progress in targeting the similar Ras protein is illuminating new strategies for specifically inhibiting oncogenic GTPases. …”
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28
Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.
Published 2003“…Moreover, IDabs selected for binding to the RAS protein could inhibit RAS-dependent oncogenic transformation of NIH3T3 cells. …”
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Oncogenic KRAS: Signaling and Drug Resistance
Published 2021-11-01“…RAS proteins play a role in many physiological signals transduction processes, including cell growth, division, and survival. …”
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30
Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer
Published 2020-10-01“…A better understanding of these conditions might have relevant clinical repercussions, since treatments to restore or enhance the function of RasGAPs in cancer would help circumvent the intrinsic difficulty of directly targeting the Ras protein.…”
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31
Targeting KRAS: Crossroads of Signaling and Immune Inhibition
Published 2022-08-01“…Despite huge effort for decades, targeting RAS mutations has been ‘‘undruggable’’ because of the molecular instability of RAS protein inhibition. However, the recent discovery of the KRAS G12C inhibitor paved the way to expand therapeutic options for patients with cancer harboring the KRAS G12C mutation. …”
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32
"Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders.
Published 2013“…Recently it has been recognized that somatic mutations in male germ cells that modify proliferation through dysregulation of the RAS protein pathway can lead to within-testis expansion of mutant clonal lines. …”
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Emerging Roles of Small GTPases in Islet β-Cell Function
Published 2021-06-01“…Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily regulate glucose-stimulated insulin secretion in the pancreatic islet β-cell. …”
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34
Von recklinghausen disease: one patient – various problems
Published 2016-06-01“…This counteracts possible overactivity of RAS (protein)/MAPK (mitogen-activated protein kinase) and RAS/PI3K/AKT/mTOR (phoshatydyloinositol-3-kinase/V-akt murine thy-moma viral oncogene homologue/mammalian target of rapamycin) signaling transduction pathways, preventing from uncontrolled cell proliferation and subsequent tumor formation. …”
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35
Identification of the potential targets for keloid and hypertrophic scar prevention
Published 2018-08-01“…The up-regulated genes were closely related with Rho protein signal transduction, cytoskeleton organization, and Ras protein signal transduction related biological process. …”
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36
Pan-Cancer Analysis of Clinical Relevance via Telomere Maintenance Mechanism
Published 2021-10-01“…Patients with metastasis had a poor prognosis in the ALT group (<i>p <</i> 0.006) subjected to RAS protein signal transduction. Glioblastoma patients had poor prognosis in NDTMM (<i>p</i> < 0.0043) and showed high levels of myeloid leukocyte activation. …”
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Computer-Aided Drug Design Boosts RAS Inhibitor Discovery
Published 2022-09-01“…On the one hand, the structural properties of the RAS protein make it difficult to find inhibitors specifically targeted to it. …”
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38
Entropy in Biochemical Failure
Published 2022-01-01“…The ab-initio determination of the thermodynamic properties of the hydrolysis of the GTP gamma-phosphate in normal and abnormal cell functions of the RAS protein mutant Thr (Q61) leads to a description of energy cycle deviations in the abnormal mitogen-activated protein kinase cascade.1 A predictive non-equilibrium probability statement describing the nonlinear changes for these open and finite-lifetime systems follows from reasonable enthalpy and entropy values between the normal and mutated forms based on structures of the GTPase states at the allosteric site. …”
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Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Published 2019“…These fused compounds add to the growing catalog of RAS protein-protein inhibitors and show that building a chemical series by crossing over two chemical series is a strategy to create RAS-binding small molecules.…”
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40
Ras2 Is Responsible for the Environmental Responses, Melanin Metabolism, and Virulence of <i>Botrytis cinerea</i>
Published 2023-03-01“…Ras proteins are monomeric G proteins that are ubiquitous in fungal cells and play important roles in fungal growth, virulence, and environmental responses. …”
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