Finding the "dark matter" in human and yeast protein network prediction and modelling. by Juan A G Ranea, Ian Morilla, Jon G Lees, Adam J Reid, Corin Yeats, Andrew B Clegg, Francisca Sanchez-Jimenez, Christine Orengo

“…Some of this dark matter shows enrichment of particular functions and contains key functional elements of protein networks, such as hubs associated with important functional areas like the regulation of Ras protein signal transduction in human cells. Thus, characterising this large and functionally important dark matter, elusive to established experimental designs, may be crucial for modelling biological systems. …”
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Current Landscape of Non-Small Cell Lung Cancer: Epidemiology, Histological Classification, Targeted Therapies, and Immunotherapy by Olga Rodak, Manuel David Peris-Díaz, Mateusz Olbromski, Marzenna Podhorska-Okołów, Piotr Dzięgiel

“…Nevertheless, one of the most frequent NSCLC molecular sub-types remains without successful treatment: the K-Ras protein. In this review, we discuss the current NSCLC landscape treatment focusing on targeted therapy and immunotherapy, including first- and second-line monotherapies, immune checkpoint inhibitors with chemotherapy treatment, and approved predictive biomarkers.…”
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H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status by Guann-An Chen, Yun-Ru Lin, Hai-Ting Chung, Lih-Hwa Hwang

“…These results reveal that the H-Ras protein plays a role in promoting MAVS signalosome assembly in the mitochondria, whereas oncogenic H-Ras exerts a negative effect on type I IFN responses.…”
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PKA and HOG signaling contribute separable roles to anaerobic xylose fermentation in yeast engineered for biofuel production. by Ellen R Wagner, Kevin S Myers, Nicholas M Riley, Joshua J Coon, Audrey P Gasch

“…We previously revealed that loss-of-function mutations in the stress-responsive MAP kinase HOG1 and negative regulator of the RAS/Protein Kinase A (PKA) pathway, IRA2, enhances anaerobic xylose fermentation. …”
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Evaluation of water quality parameters, growth and proximate composition of juvenile crab, Portunus pelagicus cultured in RAS and non RAS system by S.M. Shoyaib Kohinoor, Aziz Arshad, S.M. Nurul Amin, Mohd Salleh Kamarudin, Muhammad Aliyu Sulaiman

“…The carapace width, weight gain and specific growth rate (SGR) were significantly (P <0.05) higher in RAS. Protein content (22.65 ± 0.11%) in crab also were significantly (P <0.05) higher in RAS compared with crab protein (21.41 ± 0.12%) cultured in CAS. …”
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NRAS and BRAF mutation frequency in primary oral mucosal melanoma by Buery, R.R., Siar, C.H., Katase, N., Gunduz, M., Lefeuvre, M., Fujii, M., Inoue, M., Setsu, K., Nagatsuka, H.

“…The purpose of this study was to determine RAS protein expression and NRAS and BRAF mutation in 18 primary OMM cases using immunohistochemistry and mutation analysis. …”
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EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression by Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He

“…Mechanistically, circ_0042881 promoted BC progression by sponging miR-217 to relieve its inhibition effect in son of sevenless 1 (SOS1), which further activated RAS protein and initiated downstream signaling cascades, including MEK/ERK pathway and PI3K/AKT pathway. …”
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Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras by Manish Kumar Singh, Giulia Zago, Irina Veith, Jacques Camonis, Mathieu Coppey, Maria Carla Parrini

“…In conclusion, this work reveals that autophagy organelles are polarized toward the cell front during migration and that their spatial-temporal dynamics are altered in motile cancer cells that express an oncogenic Ras protein.…”
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KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy by Enrico Gurreri, Giannicola Genovese, Luigi Perelli, Antonio Agostini, Geny Piro, Carmine Carbone, Giampaolo Tortora

“…Despite this critical role, its characteristics have made direct targeting of the RAS protein extremely difficult. KRAS regulates development, cell growth, epigenetically dysregulated differentiation, and survival in PDAC through activation of key downstream pathways, such as MAPK-ERK and PI3K-AKT-mammalian target of rapamycin (mTOR) signaling, in a KRAS-dependent manner. …”
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The Cdc25 and Ras1 Proteins of <i>Candida albicans</i> Influence Epithelial Toxicity in a Niche-Specific Way by Stefanie Wijnants, Jolien Vreys, Jana Nysten, Patrick Van Dijck

“…<i>C. albicans</i> holds a second, atypical, Ras protein, Ras2, but its function in PKA activation is still unclear. …”
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Crucial Role of Oncogenic <i>KRAS</i> Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications by Anabela Ferreira, Flávia Pereira, Celso Reis, Maria José Oliveira, Maria João Sousa, Ana Preto

“…KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. …”
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CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis by Jean-Frederic Olivier, David Langlais, Thiviya Jeyakumar, Maria J. Polyak, Luc Galarneau, Romain Cayrol, Hua Jiang, Kelly R. Molloy, Guoyue Xu, Harumi Suzuki, John LaCava, Philippe Gros, Nassima Fodil

“…Here, we identified the Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) and the RAS Protein Activator Like 3 (RASAL3) as CCDC88B physical and functional interactors. …”
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Comparative Proteomic Analysis of tPVAT during Ang II Infusion by Xiuying Liang, Haijing Guan, Jingwen Sun, Yan Qi, Wenjuan Yao

“…In addition, some novel proteins, potentially associated with Ang II infusion, were identified, such as acyl-CoA carboxylase α, very long-chain acyl-CoA synthetase (ACSVL), uncoupling protein 1 (UCP1), perilipin, RAS protein-specific guanine nucleotide-releasing factor 2 (RasGRF2), and hypoxia inducible factor 1α (HIF-1α). …”
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DNA methylation profiling in Trisomy 21 females with and without breast cancer by Yosra Bejaoui, Sara Alresheq, Sophie Durand, Marie Vilaire-Meunier, Louise Maillebouis, Ayman Al Haj Zen, André Mégarbané, André Mégarbané, Nady El Hajj, Nady El Hajj

“…The differentially methylated CpG sites were enriched for processes related to serine-type peptidase activity, epithelial cell development, GTPase activity, bicellular tight junction, Ras protein signal transduction, etc. On the other hand, the epigenetic age acceleration analysis showed no difference between T21-BC and T21-BCF patients.ConclusionsThis is the first study to investigate DNA methylation changes in Down syndrome women with and without breast cancer and it could help shed light on factors that protect against breast cancer in DS.…”
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Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation by Robert Ferguson, Karen Aughton, Anthony Evans, Victoria Shaw, Jane Armstrong, Adam Ware, Laura Bennett, Eithne Costello, William Greenhalf

“…We propose that, during tumorigenesis, cancer cells expressing wild-type N-Ras protein are selected because the protein protects cancer cells from the deleterious effects of the cell cycle-independent induction of cyclins by mutant K-Ras. …”
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BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions by Nicolas Bery, Abimael Cruz-Migoni, Carole JR Bataille, Camilo E Quevedo, Hanna Tulmin, Ami Miller, Angela Russell, Simon EV Phillips, Stephen B Carr, Terence H Rabbitts

“…The RAS biosensors represent a useful tool to investigate and characterize the potency of anti-RAS inhibitors in cells and more generally any RAS protein-protein interaction (PPI) in cells.…”
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YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1 by Patrícia Barros, Ana M. Matos, Paulo Matos, Peter Jordan

“…In fact, we showed that depletion of SHC1 or inhibition of MAPK pathway signaling was sufficient to improve rescued F508del-CFTR surface levels, whereas an ectopic increase in pathway activation downstream of SHC1, through the use of a constitutively active H-RAS protein, abrogated the stabilizing effect of YES1 inhibition on rescued F508del-CFTR. …”
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The role of oncogenes and tumor suppressor genes in determining survival rates of lung cancer patients in the population of North Sumatra, Indonesia [version 2; peer review: 2 appr... by Noni Novisari Soeroso, Noverita Sprinse Vinolina, Fannie Rizki Ananda, Johan Samuel Sitanggang

“…Sequencing analysis was carried out to determine the mutations of EGFR exon 19 and 21, RAS protein exon 2, and TP53 exon 5-6 and 8-9. Data input and analysis were conducted using statistical analysis software for Windows. …”
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In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation by Mehreen Ghufran, Haider Ali Khan, Mehran Ullah, Sabreen Ghufran, Muhammad Ayaz, Muhammad Siddiq, Syed Shams ul Hassan, Simona Bungau

“…Mutations in genes encoding the Ras protein drive the signaling cascades essential for malignant transformation, tumour angiogenesis, and metastasis and are responsible for above 30% of all human cancers. …”
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<i>RASAL1</i> and <i>ROS1</i> Gene Variants in Hereditary Breast Cancer by Federica Isidori, Isotta Bozzarelli, Simona Ferrari, Lea Godino, Giovanni Innella, Daniela Turchetti, Elena Bonora

“…We found damaging variants in <i>NPL</i> (N-Acetylneuraminate Pyruvate Lyase), <i>POLN</i> (DNA Polymerase Nu), <i>RASAL1</i> (RAS Protein Activator Like 1) and <i>ROS1</i> (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase), shared by the corresponding cousin pairs. …”
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