Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF3 – complexes by Patrick Baumann, Yi Jin

“…This study expands the application of metal fluoride complexes in revealing major and minor conformational changes of dynamic and modified Ras proteins.…”
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Prospects for the use of statins in the treatment of neurofibromatosis type 1 by R. N. Mustafin

“…This leads to the development of tumors. Ras proteins undergo prenylation, which is inhibited by inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. …”
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Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes by Jun-yi Zhu, Xiaohu Huang, Yulong Fu, Yin Wang, Pan Zheng, Yang Liu, Zhe Han

“…However, it is difficult to directly target oncogenic RAS proteins for therapeutic intervention. We have developed a Drosophila acute myeloid leukemia model induced by human KRASG12V, which exhibits a dramatic increase in myeloid-like leukemia cells. …”
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Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members by Panagiotis G. Adamopoulos, Panagiotis Tsiakanikas, Michaela A. Boti, Andreas Scorilas

“…The complicity of human RAS proteins in cancer is a well-documented fact, both due to the mutational hyperactivation of these GTPases and the overexpression of the genes encoding these proteins. …”
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The Importance of Being PI3K in the RAS Signaling Network by Cristina Cuesta, Cristina Arévalo-Alameda, Esther Castellano

“…Ras proteins are essential mediators of a multitude of cellular processes, and its deregulation is frequently associated with cancer appearance, progression, and metastasis. …”
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The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering. by Guzmán, C, Šolman, M, Ligabue, A, Blaževitš, O, Andrade, D, Reymond, L, Eggeling, C, Abankwa, D

“…However, information on how much the membrane organization of these lipid-modified proteins impacts on their signaling is still scarce. Ras proteins are organized into membrane nanoclusters, which are necessary for Ras-MAPK signaling. …”

Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives by Renata Tisi, Vadim Gaponenko, Marco Vanoni, Elena Sacco

“…After a summary of Ras proteins molecular and regulatory features and Ras-dependent pathways relevant for drug development, we point out the most promising inhibitory approaches, the known druggable sites of wild-type and oncogenic Ras mutants, and describe the known natural compounds capable of attenuating Ras signaling. …”
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Comparison of Phytochemical Composition and Untargeted Metabolomic Analysis of an Extract from <i>Cnidoscolus aconitifolius</i> (Mill.) I. I. Johnst and <i>Porophyllum ruderale</i>... by Ángel Félix Vargas-Madriz, Ivan Luzardo-Ocampo, Ulisses Moreno-Celis, Octavio Roldán-Padrón, Jorge Luis Chávez-Servín, Haydé A. Vergara-Castañeda, Mónica Martínez-Pacheco, Carmen Mejía, Teresa García-Gasca, Aarón Kuri-García

“…Rutin/epigallocatechin gallate displayed the highest affinity to APC and K-RAS proteins in silico. Further research is needed to experiment on other cell lines. …”
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Farnesyltransferase inhibitors as radiation sensitizers. by Brunner, T, Gupta, A, Shi, Y, Hahn, S, Muschel, R, Mckenna, W, Bernhard, E

“…RESULTS: Blocking the prenylation of Ras proteins in cell lines with Ras activated by mutations or receptor signalling resulted in radiation sensitization in in vitro and in vivo. …”

Abrogation of oncogenic k-ras function by andrographolide derivatives via in silico, in vitro, and in vivo approaches by Quah, Shun Ying

“…The rat sarcoma (Ras) proteins are small guanosine triphosphatases (GTPases) that act as molecular switches in major signalling pathways involved in cell proliferation, differentiation, and survival, such as mitogenactivated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) cascades. …”
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Aggregation of lipid-anchored full-length H-Ras in lipid bilayers: simulations with the MARTINI force field. by Hualin Li, Alemayehu A Gorfe

“…In this work, we used coarse-grained (CG) molecular dynamics simulations to investigate the molecular mechanism by which full-length H-ras proteins form nanoclusters in a model membrane. We chose two different conformations of H-ras that were proposed to represent the active and inactive state of the protein, and a domain-forming model bilayer made up of di16:0-PC (DPPC), di18:2-PC (DLiPC) and cholesterol. …”
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Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib by Aoife Nolan, Cinzia Raso, Walter Kolch, Alex von Kriegsheim, Kieran Wynne, David Matallanas

“…RAS proteins are key regulators of cell signalling and control different cell functions including cell proliferation, differentiation, and cell death. …”
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Regulation of Ras Signaling by S-Nitrosylation by Sónia Simão, Rafaela Ribeiro Agostinho, Antonio Martínez-Ruiz, Inês Maria Araújo

“…After translation, Ras proteins can be targets of post-translational modifications (PTM), which can alter the intracellular dynamics of the protein. …”
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TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization by Alexandros Damalas, Ivana Vonkova, Marijonas Tutkus, Dimitrios Stamou

“…This process called epithelial to mesenchymal transition (EMT) is triggered by transforming growth factor (TGFβ) but for gaining the full invasive potential an interplay between signaling of TGFβ and Ras GTPases is required. Ras proteins possess a lipidated domain that mediates Ras association with the plasma membrane, which is essential for Ras biological functions. …”
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Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D by Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu

“…Abstract Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. …”
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The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression by Peter Dietrich, Claus Hellerbrand, Anja Bosserhoff

“…The delta subunit of <i>rod-specific photoreceptor cGMP phosphodiesterase</i> (PDE6D) regulates the trafficking of RAS proteins to the plasma membrane and thereby contributes to RAS activation. …”
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Radiation sensitization by inhibition of activated Ras. by Brunner, T, Hahn, S, Mckenna, W, Bernhard, E

“…RESULTS: Radiation sensitization was achieved in vitro and in vivo blocking the prenylation of Ras proteins in cell lines with Ras activated by mutations or receptor signaling. …”

Ras inhibitors and radiation therapy. by Jones, H, Hahn, S, Bernhard, E, Mckenna, W

“…Mutated Ras produces proteins that remain locked in a constitutively active state, thereby relaying uncontrolled signals. Ras proteins are guanosine triphosphate-binding proteins that play a pivotal role in the control of many cellular processes, including growth and differentiation. …”

Diffusion kernel-based predictive modeling of KRAS dependency in KRAS wild type cancer cell lines by Bastian Ulmer, Margarete Odenthal, Reinhard Buettner, Wilfried Roth, Michael Kloth

“…However, even without such activating mutations, RAS proteins represent core components in signal integration of several membrane-bound kinases. …”
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Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme by Valentina Palacio-Castañeda, Bas van de Crommert, Elke Verploegen, Mike Overeem, Jenny van Oostrum, Wouter P.R. Verdurmen

“…In two-dimensional tumor cell cultures, complete degradation of Ras proteins after 24 h was observed with EpCAM-targeted Ras degraders fused to ETA or DT in EpCAM-overexpressing MCF7 and HCT116 cells, with median inhibition concentration values at sub-nanomolar levels. …”
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