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Membrane Fusion and SNAREs: Interaction with Ras Proteins
Published 2022-07-01Subjects: “…Ras proteins…”
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The ancestral type of the R-RAS protein has oncogenic potential
Published 2024-02-01“…Abstract Background The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. …”
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The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis
Published 2018-02-01Subjects: “…RAS proteins…”
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Angiotensin II profile and mRNA encoding RAS proteins during bovine follicular wave
Published 2011-12-01“…The objective of the present study was to characterise the AngII profile and the mRNA encoding RAS proteins in a bovine follicular wave. Cows were ovariectomised when the size between the largest (F1) and the second largest follicle (F2) was not statistically different (day 2), slightly different (day 3), or markedly different (day 4). …”
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A study of lipid-mediated clustering of oncogenic Ras proteins on cell membrane using nanotopography engineering
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Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation.
Published 2003“…We have applied in vivo intracellular antibody capture (IAC) technology to isolate human intrabodies which bind to the oncogenic RAS protein. IAC facilitates the capture of antibody fragments, in this case single-chain Fvs (scFvs), which tolerate reducing environments, such as the cytoplasm of cancer cells. …”
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RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension
Published 2022-02-01“…RAS protein activator like 2 (Rasal2) exerts pro-proliferative effect in several types of cells. …”
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Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research
Published 2021-07-01Subjects: Get full text
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GTP-Bound N-Ras Conformational States and Substates Are Modulated by Membrane and Point Mutation
Published 2024-01-01Subjects: Get full text
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Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics
Published 2024-01-01Subjects: Get full text
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Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission
Published 2022-05-01Subjects: Get full text
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The centaurin gamma-1 GTPase-like domain functions as an NTPase.
Published 2007Subjects:Journal article -
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The Role of the Guanosine Nucleotide-Binding Protein in the Corpus Luteum
Published 2021-05-01“…Recently, we focused on the role of RAS protein in the ovarian corpus luteum. RAS protein plays a vital role in the modulation of cell survival, proliferation, and differentiation by molecular pathway signaling. …”
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Mechanism of the mitogenic influence of hyperinsulinemia
Published 2011-06-01“…<p>Abstract</p> <p>Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression of cancer and atherosclerosis. …”
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The metabolic landscape of RAS-driven cancers from biology to therapy
Published 2021“…Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. …”
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Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach
Published 2023-11-01“…However, finding effective drugs that can bind to the RAS protein remains challenging. This drove us to explore new compounds that could inhibit tumor growth, particularly in cancers that harbor K-Ras mutations. …”
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