A case series of clinical and hematological profile of juvenile myelomonocytic leukemia by Anurag Saha, Varnika Rai, Sneha Kakoty, Jyoti Sawhney, Tribhuvan Pratap Singh Kourav

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The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion by Jun Zhang, Xinqiong Liu, Yali Gao

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Trametinib restores the central conducting lymphatic flow in a premature infant with Noonan syndrome by Erika K. S. M. Leenders, Lotte E. R. Kleimeier, Lauren C. Weeke, Catelijne H. Coppens, Willemijn M. Klein, Jos M.T. Draaisma

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Mutation analysis of SHP2, SOS1, and SOS2 related to dysregulation of Ras/MAPK pathway in Noonan syndrome by Nihayatul Karimah

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RASopathy Cohort of Patients Enrolled in a Brazilian Reference Center for Rare Diseases: A Novel Familial LZTR1 Variant and Recurrent Mutations by Chaves Rabelo N, Gomes ME, de Oliveira Moraes I, Cantagalli Pfisterer J, Loss de Morais G, Antunes D, Caffarena ER, Llerena Jr J, Gonzalez S

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Extracranial Vascular Anomalies Driven by RAS/MAPK Variants: Spectrum and Genotype–Phenotype Correlations by Vanessa F. Schmidt, Friedrich G. Kapp, Constantin Goldann, Linda Huthmann, Beatrix Cucuruz, Richard Brill, Veronika Vielsmeier, Caroline T. Seebauer, Armin‐Johannes Michel, Max Seidensticker, Wibke Uller, Jakob B. W. Weiß, Alena Sint, Beate Häberle, Julia Haehl, Alexandra Wagner, Johanna Cordes, Annegret Holm, Denny Schanze, Jens Ricke, Melanie A. Kimm, Walter A. Wohlgemuth, Martin Zenker, Moritz Wildgruber

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Familial schwannomatosis carrying LZTR1 variant p.R340X with brain tumor: A case report by Masaki Ibe, Shinobu Tamura, Hideki Kosako, Yusuke Yamashita, Masamichi Ishii, Masaoh Tanaka, Hiroyuki Mishima, Akira Kinoshita, Sadahiro Iwabuchi, Shuhei Morita, Ko-ichiro Yoshiura, Shinichi Hashimoto, Naoyuki Nakao, Shigeaki Inoue

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NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas by Camille Tlemsani, Nicolas Pécuchet, Aurelia Gruber, Ingrid Laurendeau, Claire Danel, Marc Riquet, Françoise Le Pimpec‐Barthes, Elizabeth Fabre, Audrey Mansuet‐Lupo, Diane Damotte, Marco Alifano, Armelle Luscan, Benoit Rousseau, Dominique Vidaud, Jennifer Varin, Beatrice Parfait, Ivan Bieche, Karen Leroy, Pierre Laurent‐Puig, Benoit Terris, Helene Blons, Michel Vidaud, Eric Pasmant

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A Patient with Noonan Syndrome with a KRAS Mutation Who Presented Severe Nerve Root Hypertrophy by Yoshihito Ando, Mikio Sawada, Tadataka Kawakami, Mitsuya Morita, Yoko Aoki

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Undiagnosed RASopathies in infertile men by Anna-Grete Juchnewitsch, Kristjan Pomm, Avirup Dutta, Erik Tamp, Anu Valkna, Kristiina Lillepea, Eisa Mahyari, Stanislav Tjagur, Galina Belova, Viljo Kübarsepp, Viljo Kübarsepp, Helen Castillo-Madeen, Antoni Riera-Escamilla, Lisanna Põlluaas, Liina Nagirnaja, Olev Poolamets, Vladimir Vihljajev, Mailis Sütt, Nassim Versbraegen, Nassim Versbraegen, Sofia Papadimitriou, Sofia Papadimitriou, Sofia Papadimitriou, Robert I. McLachlan, Keith A. Jarvi, Peter N. Schlegel, Sven Tennisberg, Paul Korrovits, Katinka Vigh-Conrad, Moira K. O’Bryan, Kenneth I. Aston, Tom Lenaerts, Tom Lenaerts, Tom Lenaerts, Donald F. Conrad, Donald F. Conrad, Laura Kasak, Margus Punab, Margus Punab, Margus Punab, Maris Laan

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Patient engagement in the design of clinical research in Noonan syndrome spectrum disorders: a scoping review by Dagmar K. Tiemens, Jacqueline Nugteren, Erika Leenders, Ellen Wingbermühle, Carina A. C. M. Pittens, Jos M. Th. Draaisma

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Editorial: Endocrine aspects of Noonan syndrome and related syndromes by Giorgio Radetti, Thomas Edouard, Laura Mazzanti, Marco Tartaglia, Martin Zenker

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Rasopathies case report: concurrence of two pathogenic variations de novo in NF1 and KRAS genes in a patient by Irene Baquedano Lobera, Silvia Izquierdo Álvarez, María Jesús Oliván del Cacho

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Clinical profile of comorbidity of rare diseases in a Tunisian patient: a case report associating incontinentia pigmenti and Noonan syndrome by Nehla Ghedira, Arnaud Lagarde, Karim Ben Ameur, Sahar Elouej, Rania Sakka, Emna Kerkeni, Fatma-Zohra Chioukh, Sylviane Olschwang, Jean-Pierre Desvignes, Sonia Abdelhak, Valerie Delague, Nicolas Lévy, Kamel Monastiri, Annachiara De Sandre-Giovannoli

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Non-Mammalian Models for Understanding Neurological Defects in RASopathies by Mario Rodríguez-Martín, Juan Báez-Flores, Vanessa Ribes, María Isidoro-García, Jesus Lacal, Pablo Prieto-Matos

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Etiology and Treatment of Growth Delay in Noonan Syndrome by Fernando Rodríguez, Ximena Gaete, Ximena Gaete, Fernando Cassorla

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Dissecting the Natural Patterns of Progression and Senescence in Pediatric Low-Grade Glioma: From Cellular Mechanisms to Clinical Implications by David Gorodezki, Martin U. Schuhmann, Martin Ebinger, Jens Schittenhelm

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RNA atlas and competing endogenous RNA regulation in tissue-derived exosomes from luminal B and triple-negative breast cancer patients by Ji Wang, Ji Wang, Xianyu Zhang, Zilong You, Yuhuan Meng, Xijie Fan, Guangdong Qiao, Da Pang

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The most important problems and needs of rasopathy patients with a noonan syndrome spectrum disorder by Dagmar K. Tiemens, Lotte Kleimeier, Erika Leenders, Ellen Wingbermühle, Renee L. Roelofs, Barbara Sibbles, Floor S.M. Oostwegel, Eva Vroonland, Conny van Leeuwen, Hanneke Niessen, Paul Sonnega, Anniek Duursma, Michel A. A. P. Willemsen, Jos M. T. Draaisma, Carina A.C.M. Pittens

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EPHB4-RASA1-Mediated Negative Regulation of Ras-MAPK Signaling in the Vasculature: Implications for the Treatment of EPHB4- and RASA1-Related Vascular Anomalies in Humans by Di Chen, Martijn A. Van der Ent, Nathaniel L. Lartey, Philip D. King

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