Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells by Forbester, J, Lees, E, Goulding, D, Forrest, S, Yeung, A, Speak, A, Clare, S, Coomber, E, Mukhopadhyay, S, Kraiczy, J, Schreiber, F, Lawley, T, Hancock, R, Uhlig, H, Zilbauer, M, Powrie, F, Dougan, G

“…The antimicrobial phenotype was absent in hIPSCs derived from a patient harboring a homozygous mutation in the IL10RB gene that inactivates the IL-22 receptor but was restored by genetically complementing the IL10RB deficiency. …”

Case report: Fibrotic interstitial lung disease as the initial manifestation of hereditary pulmonary alveolar proteinosis caused by CSF2RB mutation by Qiuhong Li, Huikang Xie, Manhui Li, Kebin Cheng

“…Whole exome sequencing identified a rare homozygous frame shift mutation (c.304_305del:p.S102Ffs*5) in exon 3 of the CSF2RB gene in our patient. This case represents a rare occurrence of fibrotic interstitial lung disease in PAP.…”
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Bioinformatics Toxicity Assessment of RB Protein from Transgenic Potato Resistant to Phytophthora infestans by Toto Hadiarto, Alberta Dinar Ambarwati

“…Bioinformatics analysis was conducted by first translating the RB gene into an amino acid sequence by using the Emboss Transeq program from the EMBL-EBI website. …”
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Novel Constructions to Enable the Integration of Genes into the Agrobacterium tumefaciens C58 Chromosome by Lan-Ying Lee, Jaime M. Humara, Stanton B. Gelvin

“…A third plasmid contains, in addition to the lacZ, lacIq, and β-lactamase genes within the pgl/picA locus, a sacRB gene cassette within the vector to counterselect against the presence of the vector within A. tumefaciens. …”
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Aberrant cytoplasmic accumulation of retinoblastoma protein in basal cells may lead to increased survival in malignant canine mammary tumours by S. Gautam, N.K. Sood, K. Gupta

“…The retinoblastoma susceptibility gene RB-1 is a tumour suppressor gene that encodes a protein (Rb) that regulates the transition from the G1 phase to the S phase of the cell cycle. Inactivation of the Rb gene has been shown in a variety of human tumours, including breast, ovarian, hepatic, prostatic, and endometrial carcinomas. …”
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Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease by A. V. Sinitskaya, M. V. Khutornaya, M. Yu. Sinitsky, O. N. Khryachkova, M. A. Asanov, A. V. Ponasenko

“…Associations of polymorphic variants rs1800871 and rs1800872 of the IL10 gene, rs1205 of the CRP gene, and rs375947 of the IL12RB gene can be an important link in the pathogenesis of rheumatic heart disease and can later be used as biological markers for a personalized assessment of the disease risk.…”
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Higher Copy Numbers of the Potato RB Transgene Correspond to Enhanced Transcript and Late Blight Resistance Levels by James M. Bradeen, Massimo Iorizzo, Dimitre S. Mollov, John Raasch, Lara Colton Kramer, Benjamin P. Millett, Sandra Austin-Phillips, Jiming Jiang, Domenico Carputo

“…Disease resistance was enhanced as copy numbers and transcript levels increased. The RB gene, like many other disease resistance genes, is constitutively transcribed at low levels. …”
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Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo by Ursula Ehmer, Anne-Flore Zmoos, Raymond K. Auerbach, Dedeepya Vaka, Atul J. Butte, Mark A. Kay, Julien Sage

“…Here, we show that, in contrast, deletion of the entire Rb gene family in mature hepatocytes is not sufficient for their long-term proliferation. …”
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The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. by Maria Teresa Sáenz Robles, Ashley Case, Jean-Leon Chong, Gustavo Leone, James M Pipas

“…Indeed, many tumors harbor mutations in the RB gene and the pRb-E2F pathway is compromised in nearly all types of cancers. …”
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Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells by Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh

“…Additionally 2-fold increases in cyclin D1 expression and retinoblastoma (RB) gene product phosphorylation were observed within 4 hours of treatment. …”
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The correlation between HPV infection and p53, pRb, KI-67 as well as tunnel expression of cervical carcinoma by Perpustakaan UGM, i-lib

“…In cervical cancer the role of HPV infection in cells proliferation and apoptosis has not yet been defined up to now, since mutation of p53 gene and Rb gene in cervical cancer is very rare. Methodes: Thirty-eight block parafin cases of squamous cell carcinoma of the cervix were stained immunohistochemically with polyclonal antibody against HPV and monoclonal antibody against p53, Rb, Ki-67 and Tunnel. with chromogen DAB and counterstain Hematoxyllin Meyer. …”

Prenatal Diagnosis of Retinoblastomas: A Scoping Review by Rodriguez A, Kelley C, Patel A, Ramasubramanian A

“…Therefore, future parents with a family history of retinoblastoma are strongly advised to get tested for retinoblastoma (Rb) gene mutations; if one of the parents is positive for a mutated allele of the RB1 gene, there is a 45% chance that their child will inherit a mutated allele of the retinoblastoma gene, rendering the allele non-functional in all of the cells of the individual and predisposing the child to a higher risk of developing retinoblastoma as well as other secondary cancers. …”
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Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance. by Dennis A Halterman, Yu Chen, Jiraphan Sopee, Julio Berduo-Sandoval, Amilcar Sánchez-Pérez

“…This disease has remained particularly problematic despite intensive breeding efforts to integrate resistance into cultivated potato, largely because of the pathogen's ability to quickly evolve to overcome major resistance genes. The RB gene, identified in the wild potato species S. bulbocastanum, encodes a protein that confers broad-spectrum resistance to most P. infestans isolates through its recognition of highly conserved members of the corresponding pathogen effector family IPI-O. …”
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Mekanisme Kontrol Siklus Sel (Suatu Tinjauan Khusus Peran Protein Regulator pada Jalur Retinoblastoma (Rb)) by H. N. Istindah, Elza Ibrahim Auerkari

“…Progression through the cell cycle is controlled by a group of kinases called cyclin-dependent kinases (CDK) which are thought to phosphorylate cellular substrate, such as the retinoblastoma (Rb) gene in Rb pathway that are responsible for progression into each of the phases of cell cycle. …”
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Molecular determinants of resistance activation and suppression by Phytophthora infestans effector IPI-O. by Yu Chen, Zhenyu Liu, Dennis A Halterman

“…Despite intensive breeding efforts, potato late blight, caused by the oomycete pathogen Phytophthora infestans, remains a threat to potato production worldwide because newly evolved pathogen strains have consistently overcome major resistance genes. The potato RB gene, derived from the wild species Solanum bulbocastanum, confers resistance to most P. infestans strains through recognition of members of the pathogen effector family IPI-O. …”
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Retinoblastoma: present scenario and future challenges by Vishnu Vardhan Byroju, Aisha Shigna Nadukkandy, Marco Cordani, Lekha Dinesh Kumar

“…According to the Knudson hypothesis, also known as the two hit hypothesis, two hits on the retinoblastoma susceptibility (RB) gene is often considered as the initiating event in the development of the disease. …”
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A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. by Bernadette Sosa-García, Volkan Gunduz, Viviana Vázquez-Rivera, W Douglas Cress, Gabriela Wright, Haikuo Bian, Philip W Hinds, Pedro G Santiago-Cardona

“…We generated knockout mice in which the RB gene was excised specifically in osteoblasts using the cre-lox P system and found that osteoblasts from pRb knockout mice did not assemble adherens junction at their membranes. pRb depletion in wild type osteoblasts using RNAi also disrupted adherens junctions. …”
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Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil. by Felipe Jules de Araújo Santos, Lener Santos da Silva, José do Espírito Santo Júnior, Tirza Gabrielle Ramos de Mesquita, Mara Lúcia Gomes de Souza, Moacir Couto de Andrade Júnior, Sinésio Talhari, Rajendranath Ramasawmy

“…The SNPs -2425G/A (rs4833248) and -330 T/G (rs2069762), located in the IL-2 gene promoter region, seem to influence the expression of the gene and the SNP +10558G/A (rs1003694) and +13295T/C (rs3212760) located in the 3rd intron of the IL-2RB gene and the 13th intron of the JAK3 gene, respectively, were studied by PCR-RFLP. …”
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p16 gene expression in basal cell carcinoma. by Eshkoor, Sima Atoallahi, Ismail, Patimah, Abdul Rahman, Sabariah, Oshkour, Soraya Ataollahi

“…In this pathway, p16INK4a, an inhibitor of Rb pathway, binds to CDK4 and CDK6 competitively with cyclin D1 to prevent phosphorylation of tumor suppressor pRB gene. Alteration of this pathway contributes to development of human cancers and also is effective in skin cancers. …”
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A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/... by Federica Piattini, Christelle Le Foll, Jan Kisielow, Esther Rosenwald, Peter Nielsen, Thomas Lutz, Christoph Schneider, Manfred Kopf

“…Candidate gene sequencing revealed a spontaneous point mutation in the LepRb gene. We investigated leptin responsiveness, leptin receptor signaling and metabolic phenotype of this novel LepRb mutant mouse variant. …”
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