Deconstructing ADAURA: It is Time to Forgo Adjuvant Platinum-Based Chemotherapy in Resected IB-IIIA EGFR+ NSCLC (Except with RB Alterations?) When Adopting Adjuvant Osimertinib by Zhang SS, Ou SI

“…There may be a potential role of adjuvant cisplatin/vinorelbine in a small subgroup of EGFR+ NSCLC patients whose tumor harbors retinoblastoma (RB) gene alterations but requires further investigation.Keywords: ADAURA, osimertinib, EGFR mutation, resected NSCLC, adjuvant, platinum-based chemotherapy, cisplatin; disease-free survival…”
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Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease by Eunah Hwang

“…Recently several studies revealed that IL-10, IL-10RA, and IL-10RB genes were involved in the development of vascular complications in hypertension and stroke. …”
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Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors by Jin Hwan Kim, Kyu Young Choi, Dong Jin Lee, Young-Soo Rho, Sung-Jin Jo

“…LOH on 9p21 was detected in 6%, 44.4%, and 47.8%, respectively. LOH on pRb gene was found in 5.3%, 20.0%, and 35.4%, respectively. …”
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Phenotypic and molecular-genotypic correlation of diseases resistance in improved varieties potato (Solanum tuberosum L.) by Baldelomar, Mariela, Gabriel, Julio, Veramendi, Silene, Terán, Ariana, Plata, Giovanna

“…The allele for RB marker that is co-localizes with the RB gene for resistance to blight was not found in any of the varieties tested. …”
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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice by Hu, Yueh-Chiang, de Rooij, Dirk G., Page, David C

“…We conditionally disrupted the Rb gene in mouse germ cells in vivo and discovered unanticipated consequences for GFRa1-protein-expressing A[subscript single] (GFRa1[superscript +] A[subscript s]) spermatogonia, the major source of male germ-line stem cells. …”
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Donors of valuable breeding traits of pea (Pisum sativum L.) by А. Vasylenko, N. Vus, I. Bezuglyi, О. Bezugla, L. Shevchenko, Е. Kucherenko, А. Glyantsev

“…Orpella (anthocyanin pigmentation of the corolla (A)) and Rezonator (stem length (Le)) were used for the grain/fodder pea breeding; Kharkivskyi Yantarnyi and Banan (seed culinary qualities) – for the groats pea breeding; Stambovyi (parchmentless pods (pv), fascicle stems (fa fas) and Asgrow sead (wrinkled seeds (r), leafless (af), multi-flowering (fn fna)) – for the garden pea breeding; Violena (the rb gene carrier – amylose-free starch) – for the technical pea breeding. …”
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A Phenotypically Silent <italic toggle="yes">vanB2</italic> Operon Carried on a Tn<italic toggle="yes">1549</italic>-Like Element in <named-content content-type="genus-species">Clo... by Daniel R. Knight, Grace O. Androga, Susan A. Ballard, Benjamin P. Howden, Thomas V. Riley

“…Notably, the C. difficile strain did not show any reduced susceptibility to vancomycin in vitro (MIC, 1 mg/liter), possibly as a result of an aberrant vanRB gene. As observed for other anaerobic species of the animal gut microbiota, C. difficile may be a reservoir of clinically important vancomycin resistance genes. …”
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Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER+HER2−Rb wild-type and knock-down in breast cancer cell lines by Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli, Giorgio Santoni

“…Subsequently, HR+HER2− MCF-7 cells were silenced for Retinoblastoma (Rb) gene, and thus, the effect of Rib in sequential or concurrent schedule with Eve for the treatment of both Rb wild type or Rb knock-down MCF-7 in vitro was evaluated. …”
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Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients by Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz, Asta Försti

“…The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Conclusions Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system.…”
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CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review by Mohammad Reza Asadi, Marziyeh Sadat Moslehian, Hani Sabaie, Mirmohsen Sharifi-Bonab, Parvin Hakimi, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Azadeh Rakhshan, Maryam Rezazadeh, Maryam Rezazadeh

“…Retinoblastoma (RB) is one of the most common childhood cancers caused by RB gene mutations (tumor suppressor gene in various patients). …”
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Early B cell transcriptomic markers of measles-specific humoral immunity following a 3rd dose of MMR vaccine by Iana H. Haralambieva, Jun Chen, Huy Quang Quach, Tamar Ratishvili, Nathaniel D. Warner, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy

“…The most significant genes included: the interleukin 20 receptor subunit beta/IL20RB gene (a subunit receptor for IL-24, a cytokine involved in the germinal center B cell maturation/response); the phorbol-12-myristate-13-acetate-induced protein 1/PMAIP1, the brain expressed X-linked 2/BEX2 gene and the B cell Fas apoptotic inhibitory molecule/FAIM, involved in the selection of high-affinity B cell clones and apoptosis/regulation of apoptosis; as well as IL16 (encoding the B lymphocyte-derived IL-16 ligand of CD4), involved in the crosstalk between B cells, dendritic cells and helper T cells. …”
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CELL CYCLE REGULATING GENES AND THEIR PROTEIN EXPRESSION IN SQUAMOUS CELL CARCINOMA OF THE LARYNX AND HYPOPHARYNX by Metka Volavšek, Damjan Glavač, Nina Gale

“…Our results suggest that Rb gene inactivation might also be important in the development of LHSCC.…”
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Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype by I. A. Goncharova, E. Yu. Bragina, I. Zh. Zhalsanova, M. B. Freidin, M. S. Nazarenko

“…The rs11065987 allele A of the ATXN2/BRAP genes, the rs11669386 A allele of the CARD8 gene, the rs2284033 allele G of the IL2RB gene, and the rs11191582 allele G of the NT5C2 gene were associated with the risk of AH. …”
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Unraveling the RNA world of retinoblastoma by Lakshmi Dhevi N. Selvan, Ranjith Kumar, Karthikeyan Sivaraman, Krishnakumar Subramanian, Debashis Sahoo, Sailaja Elchuri

“…It is the first ever cancer to have a genetic basis where inactivation of RB gene in both the alleles would cause the cancer1. …”
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Hypothalamic TTF-1 orchestrates the sensitivity of leptin by Byong Seo Park, Dasol Kang, Kwang Kon Kim, Bora Jeong, Tae Hwan Lee, Jeong Woo Park, Shioko Kimura, Jung-Yong Yeh, Gu Seob Roh, Chang-Joong Lee, Sungchil Yang, Sunggu Yang, Jae Geun Kim, Byung Ju Lee

“…We further determined that TTF-1 inhibited the transcriptional activity of the ObRb gene. In line with these findings, the selective deletion of the TTF-1 gene in ObRb-positive cells led to protective effects against diet-induced obesity via the amelioration of leptin resistance. …”
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Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population by Mariana Angulo-Aguado, Juan Camilo Carrillo-Martinez, Nora Constanza Contreras-Bravo, Adrien Morel, Katherine Parra-Abaunza, William Usaquén, Dora Janeth Fonseca-Mendoza, Oscar Ortega-Recalde

“…Various respiratory and systemic symptoms, along with the rs8178521 variant (p < 0.01; OR = 2.51; 95% CI = 1.27–4.94) in the IL10RB gene, were significantly associated with the presence of long-COVID. …”
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CSF2RB Is a Unique Biomarker and Correlated With Immune Infiltrates in Lung Adenocarcinoma by Ningning Zhu, Yueyang Yang, Haitong Wang, Peng Tang, Hongdian Zhang, Haiyan Sun, Lei Gong, Zhentao Yu, Zhentao Yu

“…Furthermore, the Kaplan–Meier plotter showed that a low CSF2RB expression was associated with poor survival and multivariate COX regression analysis revealed that the CSF2RB gene was an independent risk factor for prognosis, independent of whether patients received chemotherapy or radiotherapy. …”
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Role of Retinoblastoma Protein Family (Rb/p105 and Rb2/p130) Expression in the Histopathological Classification of Borderline Ovarian Tumors by Valeria Masciullo, Paola Valdivieso, Giulia Amadio, Angela Santoro, Giuseppe Angelico, Alessandro Sgambato, Silvia Boffo, Antonio Giordano, Giovanni Scambia, Giovanni Scambia, Gian Franco Zannoni, Gian Franco Zannoni

“…In this study, we evaluated the expression and subcellular localization of proteins of the retinoblastoma (Rb) gene family in 65 ovarian borderline tumors. Statistically significant differences were found in nuclear and cytoplasmic expressions of Rb/p105 and Rb2/p130 according to different examined histotypes. …”
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Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review by Duna Barakeh, Afaf Alsolami, Malak Abedalthagafi

“…The analysis revealed pathogenic mutations in TP53 and RB genes, as well as copy number gains in NTRK1, MDM4, and BRAF. …”
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Recombinase-based conditional and reversible gene regulation via XTR alleles by Robles-Oteiza, Camila, Yates, Travis, Cicchini, Michelle, Lauderback, Brian, Burds, Aurora A., Winslow, Monte M., Feldser, David M., Taylor, Sarah E., Cashman, Chris, Jacks, Tyler E

“…We validate our approach by targeting the p53 and Rb genes and establishing cell line and in vivo cancer model systems, to study the impact of p53 or Rb inactivation and restoration. …”
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