TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design by Howard Trachtman, Matthias Kretzler, Hailey E. Desmond, Wansuk Choi, Raymond C. Manuel, Nima Soleymanlou

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Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction by Abbigayle E. Cuomo, Sebastian Ibarraran, Sanil Sreekumar, Haote Li, Jungmin Eun, Jan Paul Menzel, Pengpeng Zhang, Frederic Buono, Jinhua J. Song, Robert H. Crabtree, Victor S. Batista, Timothy R. Newhouse

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Bounded integer model‐based analysis of psoriasis area and severity index in patients with moderate‐to‐severe plaque psoriasis receiving BI 730357 by Qing Xi Ooi, Anders Kristoffersson, Julia Korell, Mary Flack, Elodie L. Plan, Benjamin Weber

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Varied treatment pathways with no defined treatment sequencing in patients with generalized pustular psoriasis: A claims-based study by Steven R. Feldman, MD, PhD, Ran Gao, MS, Rhonda L. Bohn, ScD, Stephani Gray, MPH, Sabrina E. Walton, MSPH, Anouk Déruaz-Luyet, PhD, MPH, Jashin J. Wu, MD

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Food effect risk assessment in preformulation stage using material sparing µFLUX methodology by Corinne Jankovsky, Oksana Tsinman, Naveen Thakral

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Understanding potential participation barriers to improve trial design and outcomes: clinical trial simulation in palmoplantar pustulosis as a case study by Yakov Datsenko, Emmanuelle Clerisme-Beaty, Andreas Pinter, Satomi Kobayashi, Christian Boisvert-Huneault, David Trigos Herraez, Stacie Bell, Kimberley Kallsen, Tristan Gloede, Nobutaka Yagi, Steven Brunette, Frank Baehner, Peter Van de Kerkhof

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Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using real-world data from two large US databasesCapsule Summary by Steven R. Feldman, MD, Rhonda L. Bohn, ScD, Ran Gao, MS, Stephani Gray, MPH, Sabrina E. Walton, MSPH, Anouk Déruaz-Luyet, PhD, MPH, Jashin J. Wu, MD

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Design of a phase III, double-blind, randomised, placebo-controlled trial of BI 1015550 in patients with idiopathic pulmonary fibrosis (FIBRONEER-IPF) by Toby M Maher, Michael Kreuter, Vincent Cottin, Susanne Stowasser, Marlies S Wijsenbeek, Yi Liu, Fernando J Martinez, Luca Richeldi, Arata Azuma, Justin M Oldham, Claudia Valenzuela, Maud Gordat, Donald F Zoz

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Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver DiseaseSummary by Tianyi Chen, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, Manal F. Abdelmalek, Ricardo Henao, Paolo Guarnieri, Steven S. Pullen, Simon Gregory, Joseph Locker, J. Mark Brown, Anna Mae Diehl

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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity by Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M. Souza, Daniela Rodrigues, Danyel G. J. Jennen, Theo M. deKok, Luke Coyle, Seung‐Wook Chung, Sofia Ferreira, Heeseung Jo, Kylie A. Beattie, Colette Kelly, Carrie A. Duckworth, D. Mark Pritchard, Carmen Pin

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Decision making in clinical trials: Interim analyses, innovative design, and biomarkers by Kathleen A. Welsh‐Bohmer, Geoffrey A. Kerchner, Shobha Dhadda, Miguel Garcia, David S. Miller, Fanni Natanegara, Lars Lau Raket, Weining Robieson, Eric R. Siemers, Maria C. Carrillo, Christopher J. Weber

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International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs by Ingrid M. Pruimboom‐Brees, Swati Gupta, Nagendra Chemuturi, Helen S. Booler, Erik Nimz, Meg Ferrell Ramos, Antonello Caruso, Katie F. Maass, Vladimir Bantseev, Qihong Huang, Mary P. Choules, Jesse C. Nussbaum, Jitendra Kanodia, Christopher Thompson, Chandrasekar Durairaj

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The efficacy and safety of combined tiotropium and olodaterol via the Respimat® inhaler in patients with COPD: results from the Japanese sub-population of the Tonado® studi... by Ichinose M, Taniguchi H, Takizawa A, Grönke L, Loaiza L, Voß F, Zhao Y, Fukuchi Y

“…KG, Ingelheim, Germany; 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; 6Juntendo University School of Medicine, Tokyo, JapanBackground: The efficacy and safety of once-daily tiotropium + olodaterol (T+O) maintenance treatment was demonstrated in the large, multinational, replicate, randomized, Phase III, Tonad® 1 (NCT01431274) and 2 (NCT01431287) studies in patients with moderate to very severe COPD. …”
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Empagliflozin is associated with lower risk of cardiovascular events and all‐cause mortality in routine care in East Asia: Results from the EMPRISE study by Dae Jung Kim, Wayne H‐H Sheu, Wook‐Jin Chung, Daisuke Yabe, Kyoung Hwa Ha, Masaomi Nangaku, Elise Chia‐Hui Tan, Koichi Node, Atsutaka Yasui, Weiyu Lei, Sunwoo Lee, Laura Saarelainen, Anouk Deruaz‐Luyet, Moe H Kyaw, Yutaka Seino, EMPRISE East Asia Study Group

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Empagliflozin and Rapid Kidney Function Decline Incidence in Type 2 Diabetes: An Exploratory Analysis From the EMPA-REG OUTCOME Trial by Samy Hadjadj, Mark E. Cooper, Dominik Steubl, Michaela Petrini, Stefan Hantel, Michaela Mattheus, Christoph Wanner, Merlin C. Thomas

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Adjunctive Volasertib in Patients With Acute Myeloid Leukemia not Eligible for Standard Induction Therapy: A Randomized, Phase 3 Trial by Hartmut Döhner, Argiris Symeonidis, Dries Deeren, Judit Demeter, Miguel A. Sanz, Achilles Anagnostopoulos, Jordi Esteve, Walter Fiedler, Kimmo Porkka, Hee-Je Kim, Je-Hwan Lee, Kensuke Usuki, Stefano D'Ardia, Chul Won Jung, Olga Salamero, Heinz-August Horst, Christian Recher, Philippe Rousselot, Irwindeep Sandhu, Koen Theunissen, Felicitas Thol, Konstanze Döhner, Veronica Teleanu, Daniel J. DeAngelo, Tomoki Naoe, Mikkael A. Sekeres, Valerie Belsack, Miaomiao Ge, Tillmann Taube, Oliver G. Ottmann

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