Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge. by Alison A McCormick, Aisha Shakeel, Chris Yi, Hardeep Kaur, Ahd M Mansour, Chandra Shekhar Bakshi

“…Immune responses varied in magnitude and isotype profile, by antigen, by route of administration, and by protection in an F. tularensis LVS challenge model of disease. …”
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Gender affirming hormone therapy and transgender women fertility: Histologic predictors of germ cell presence by Lina Rigodanzo Marins, Tiago Elias Rosito, Lucia Maria Kliemann, Edson Capp, Helena von Eye Corleta

“…Hormone treatment type, route of administration, age at initiation and duration were recorded. …”
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THE STUDY OF NANOSCALE IRON SUBSTANCE FOR THE PURPOSE OF DEVELOPING PHARMACEUTICAL CAPSULE DOSAGE FORM by Z. Polova, I. Sakhanda

“…As a result of studying the problems of the route of administration chosen type of dosage form and route of administration - the solid form of release in the form of capsules for oral administration. …”
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Comparison of vaccination efficacy using live or ultraviolet-inactivated influenza viruses introduced by different routes in a mouse model by Kyeongbin Baek, Sony Maharjan, Madhav Akauliya, Bikash Thapa, Dongbum Kim, Jinsoo Kim, Minyoung Kim, Mijeong Kang, Suyeon Kim, Joon-Yong Bae, Keun-Wook Lee, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon

“…Vaccination utilizes preemptive inoculation with live virus, live attenuated virus, inactivated virus, or virus segments for optimal immune activation. The route of administration also affects the efficacy of the vaccination. …”
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Effect of atomization on the composition and structure of recombinant humanized collagen type III by Ningwen Cheng, Xinyue Zhang, Jian Wang, Danfeng Li, Ling Li, Huan Hu, Tingli Qu

“…Aerosol inhalation as the route of administration of therapeutic proteins holds significant promise due to its ability to achieve high bioavailability in non-invasive pathways. …”
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Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles by Bogdan Mîndrilă, Sandra-Alice Buteică, Ion Mîndrilă, Dan-Eduard Mihaiescu, Marina-Daniela Mănescu, Ion Rogoveanu

“…This paper examined how the intravenous (IV) or intragastric (IG) route of administration influenced the intrahepatic distribution or therapeutic effects of IONPs. …”
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Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis by Bello AE, Perkins EL, Jay R, Efthimiou P

“…Similarly, if another RA treatment is necessary to control the disease, the MTX dosage and route of administration should be maintained, with titration as needed. …”
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Comparison of vaccination efficacy using live or ultraviolet-inactivated influenza viruses introduced by different routes in a mouse model. by Kyeongbin Baek, Sony Maharjan, Madhav Akauliya, Bikash Thapa, Dongbum Kim, Jinsoo Kim, Minyoung Kim, Mijeong Kang, Suyeon Kim, Joon-Yong Bae, Keun-Wook Lee, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon

“…Vaccination utilizes preemptive inoculation with live virus, live attenuated virus, inactivated virus, or virus segments for optimal immune activation. The route of administration also affects the efficacy of the vaccination. …”
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Off-label drug use in an adult intensive care unit of a Brazilian hospital by Elana Figueiredo Chaves, José Martins de Alcântara Neto, Lívia Maria Porto Moreira, Pedro Henrique Quintela Soares de Medeiros, Paulo Andrei Milen Firmino, Gabriela Araújo de Abreu, Angelina Almeida Bastos, Arnaldo Aires Peixoto Junior, Marjorie Moreira Guedes

“…Off-label use of medication was classified by indication, dosage, route of administration, type and volume of diluent, and duration of administration. …”
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Observational study on medication administration errors at a University Hospital in Brazil: incidence, nature and associated factors by Lindemberg Assunção-Costa, Ivellise Costa de Sousa, Renata Kelly Rodrigues Silva, Ana Carla do Vale, Charleston Ribeiro Pinto, Juliana Ferreira Fernandes Machado, Cleidenete Gomes Valli, Luis Eugenio Portela Fernandes de Souza

“…The factors associated with errors were interruptions, route of administration and workload, which agrees well with the results of other national and international studies.…”
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Is it possible to enhance immune response after vaccination? The role of a probiotic with a proven positive effect on all components of the immune system by E. V. Kanner, M. L. Maksimov, I. D. Kanner, N. M. Lapkin, A. V. Gorelov

“…Most modern vaccines are live-attenuated, killed / inactivated or subunit (recombinant) vaccines, and they are designed for the parenteral route of administration. Most of these vaccines elicit a weak immune response, especially in the mucous membranes, due to the route of administration and are associated with weak cell-mediated immunity. …”
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MSC therapy attenuates obliterative bronchiolitis after murine bone marrow transplant. by Kashif Raza, Trevor Larsen, Nath Samaratunga, Andrew P Price, Carolyn Meyer, Amy Matson, Michael J Ehrhardt, Samuel Fogas, Jakub Tolar, Marshall I Hertz, Angela Panoskaltsis-Mortari

“…Interim PFT analysis showed no difference in route of administration. Improvements in PFTs were found regardless of dose frequency; but once per week worked best even when administration began late. …”
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A comparison of the efficacy and safety of oral and intravenous fludarabine in chronic lymphocytic leukemia in the LRF CLL4 trial. by Dearden, C, Richards, S, Else, M, Catovsky, D, Hillmen, P

“…We assessed retrospectively the efficacy of these two routes of administration in the LRF CLL4 trial. METHODS: A total of 777 patients were randomized from 1999-2004 to receive fludarabine, alone or with cyclophosphamide, or chlorambucil. …”

mRNA—From COVID-19 Treatment to Cancer Immunotherapy by Werner Krause

“…This review provides an overview covering mRNA from its use in the COVID-19 pandemic to cancer immunotherapy, starting from the selection of appropriate antigens, tumor-associated and tumor-specific antigens, neoantigens, the basics of optimizing the mRNA molecule in terms of stability, efficacy, and tolerability, choosing the best formulation and the optimal route of administration, to summarizing current clinical trials of mRNA vaccines in tumor therapy.…”
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Nanoencapsulation Of Thiolated Sodium Alginate: Synthesis, Drug Release And Cellular Uptake Studies by Chiu, Hocking

“…Oral drug delivery has becoming the most preferred route of administration for chemotherapeutic drugs, however its application is limited due to lack of drug targeting specificity to the localised cancerous cells but not to the normal cells. …”
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Comparison of efficacy between subcutaneous and intravenous application of moss‐aGal in the mouse model of Fabry disease by Paulina Dabrowska‐Schlepp, Andreas Busch, Jin‐Song Shen, Rachel Y. Cheong, Lone Bruhn Madsen, Daniel Mascher, Raphael Schiffmann, Andreas Schaaf

“…Subcutaneous (sc) injection, in contrast, is an established route of administration for treatment of chronic conditions. …”
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Drug-Induced Anaphylactic Shock by A. V. Matveev, A. E. Krasheninnikov, A. V. Belostotsky, D. M. Andreeva, S. D. Marchenko, E. A. Egorova

“…In 87 cases, AS was found associated with parenteral administration drugs, the intravenous route of administration being predominant (44 cases). In 97 cases, development of drug-induced AS was life-threatening and required emergency pharmacotherapy; 8 reports contained a lethal outcome record.Conclusions. …”
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Does Desmopressin Reduce Intraoperative Bleeding in Patients Who Undergo Nasal Surgery? A Systematic Review and Meta-Analysis by Sun Hong Kim, Ah Young Bae, Do Hyun Kim, Se Hwan Hwang

“…Subgroup analyses comparing the route of administration (intravenous vs. intranasal) and type of surgery (rhinoplasty vs. endoscopic sinus surgery) showed that desmopressin had a beneficial effect on intraoperative bleeding and the surgical field, regardless of the route of administration or type of surgery. …”
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Ospemifene in the Management of Vulvar and Vaginal Atrophy: Focus on the Assessment of Patient Acceptability and Ease of Use by Cagnacci A, Xholli A, Venier M

“…In addition, its route of administration minimizes those bothersome side effects intrinsic to the vaginal route of administration. …”
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Barking up the same tree: a comparison of ethnomedicine and canine ethnoveterinary medicine among the Aguaruna by Jernigan Kevin A

“…Informants provided freelists of plants given to dogs and explained the purpose, preparation and route of administration used. For each plant, informants also described any uses for treating people. …”
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