Profile of Rudolf Jaenisch <subtitle>Founding Member, Whitehead Institute for Biomedical Research, and Professor of Biology, Massachusetts Institute of Technology (MIT), Boston, MA, USA</subtitle> by Kristie Nybo

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Starting signal: Aberrant kinase activation as a trigger for SARS-CoV-2 induced axonal damage by Alexsia Richards, Rudolf Jaenisch, Rudolf Jaenisch

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Response to “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation” by Hui Yang, Haoyi Wang, Rudolf Jaenisch

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Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction by Haiting Ma, Jacob F. Jeppesen, Rudolf Jaenisch

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Approaches to pandemic prevention – the chromatin vaccine by Jielin Zhang, Philip Askenase, Rudolf Jaenisch, Clyde S. Crumpacker

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Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. by Günter Raddatz, Qing Gao, Sebastian Bender, Rudolf Jaenisch, Frank Lyko

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Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 by Anthony Flamier, Punam Bisht, Alexsia Richards, Danielle L. Tomasello, Rudolf Jaenisch

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Parent-of-Origin DNA Methylation Dynamics during Mouse Development by Yonatan Stelzer, Hao Wu, Yuelin Song, Chikdu S. Shivalila, Styliani Markoulaki, Rudolf Jaenisch

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SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology by Alexsia Richards, Max Friesen, Andrew Khalil, M. Inmaculada Barrasa, Lee Gehrke, Rudolf Jaenisch

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Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells by Stefan Semrau, Johanna E. Goldmann, Magali Soumillon, Tarjei S. Mikkelsen, Rudolf Jaenisch, Alexander van Oudenaarden

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Transgene excision has no impact on in vivo integration of human iPS derived neural precursors. by Tamara Major, Jayanthi Menon, Gordon Auyeung, Frank Soldner, Dirk Hockemeyer, Rudolf Jaenisch, Viviane Tabar

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LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells by Liguo Zhang, Punam Bisht, Anthony Flamier, M. Inmaculada Barrasa, Max Friesen, Alexsia Richards, Stephen H. Hughes, Rudolf Jaenisch

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16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis by Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel Sive

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Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons by Danielle L. Tomasello, M. Inmaculada Barrasa, David Mankus, Katia I. Alarcon, Abigail K. R. Lytton-Jean, X. Shawn Liu, Rudolf Jaenisch

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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection by Alexsia Richards, Andrew S. Khalil, Max Friesen, Troy W. Whitfield, Xinlei Gao, Tenzin Lungjangwa, Roger D. Kamm, Zhengpeng Wan, Lee Gehrke, David Mooney, Rudolf Jaenisch

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A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. by Grace X Y Zheng, Arvind Ravi, J Mauro Calabrese, Lea A Medeiros, Oktay Kirak, Lucas M Dennis, Rudolf Jaenisch, Christopher B Burge, Phillip A Sharp

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Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state by Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge

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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication. by Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schüle

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Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity by Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk

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Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity by Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk

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