Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction. by Dall'Armellina, E, Piechnik, S, Ferreira, V, Si, Q, Robson, M, Francis, J, Cuculi, F, Kharbanda, R, Banning, A, Choudhury, R, Karamitsos, T, Neubauer, S

“…METHODS: 3T CMR including T2W, T1-mapping and LGE was performed in 41 patients [of these, 78% were ST elevation MI (STEMI)] with acute MI at 12-48 hour after chest pain onset and at 6 months (6M). Patients with STEMI underwent primary PCI prior to CMR. …”

Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction by Dall'Armellina Erica, Piechnik Stefan K, Ferreira Vanessa M, Si Quang Le, Robson Matthew D, Francis Jane M, Cuculi Florim, Kharbanda Rajesh K, Banning Adrian P, Choudhury Robin P, Karamitsos Theodoros D, Neubauer Stefan

“…</p> <p>Methods</p> <p>3T CMR including T2W, T1-mapping and LGE was performed in 41 patients [of these, 78% were ST elevation MI (STEMI)] with acute MI at 12-48 hour after chest pain onset and at 6 months (6M). Patients with STEMI underwent primary PCI prior to CMR. …”
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Early changes in immunoglobulin G levels during immune checkpoint inhibitor treatment are associated with survival in hepatocellular carcinoma patients. by Lorenz Balcar, David Bauer, Katharina Pomej, Tobias Meischl, Mattias Mandorfer, Thomas Reiberger, Michael Trauner, Bernhard Scheiner, Matthias Pinter

“…However, the relative change in IgG (Δ-IgG) independently predicted OS in multivariable Cox regression analysis after adjusting for severity of liver disease, baseline AFP and CRP as well as for Δ-IgA and Δ-IgM. Patients could be stratified into high (Δ-IgG≥+14%) vs. low (Δ-IgG<+14%) risk groups (median OS: 6.4 vs. 15.9 months; p = 0.001). …”
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The Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel Invasiveness Pathway through E-Syt1 Phosphorylation by Johnson, Hannah, White, Forest M., Jun, Hyun Jung, Bronson, Roderick T., de Feraudy, Sebastien, Charest, Alain

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Beyond PARP Inhibitors in Advanced Breast Cancer Patients with Germline <i>BRCA1/2</i> Mutations: Focus on CDK4/6-Inhibitors and Data Review on Other Biological Therapies by Marta Nerone, Lorenzo Rossi, Rosaria Condorelli, Vilma Ratti, Fabio Conforti, Antonella Palazzo, Rossella Graffeo

“…Three studies retrospectively showed a reduction in the overall survival (OS) and progression-free survival (PFS) in g<i>BRCA1/2</i>m patients compared to both the germinal <i>BRCA1/2</i> wild type (g<i>BRCA1/2</i>wt) and the untested population. …”
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Importance of cardiac imaging assessment of epicardial adipose tissue after a first episode of myocardial infarction by Fabián Islas, Eva Gutiérrez, Victoria Cachofeiro, Victoria Cachofeiro, Ernesto Martínez-Martínez, Ernesto Martínez-Martínez, Gema Marín, Carmen Olmos, Irene Carrión, Sandra Gil, Patricia Mahía, Miguel Ángel Cobos, Alberto de Agustín, María Luaces

“…In these patients, baseline left ventricular ejection fraction (LVEF) after AMI was significantly lower, as well as global longitudinal strain. EAT thickness ≥ 4 m patients presented larger infarct size, higher extracellular volume, and higher T1 times than patients with EAT &lt; 4 mm. …”
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Exacerbated Neuropathy in POLAR A and M Trials Due to Redox Interaction of PledOx-Associated Mn²⁺ and Oxaliplatin-Associated Pt²⁺ by Jan Olof G. Karlsson, Per Jynge, Louis J. Ignarro

“…In POLAR A and M, the assessment of PledOx efficacy was conducted in patients that received at least six cycles of FOLFOX6, enabling analyses of efficacy in 239 A and 88 M patients. Instead of a hypothesized improvement from 40% to 20% incidence of persistent CIPN in the PledOx group, i.e., a 50% improvement, the real outcome was the opposite, i.e., an about 50% worsening in this bothersome toxicity. …”
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Chidamide plus envafolimab as subsequent treatment in advanced non‐small cell lung cancer patients resistant to anti‐PD‐1 therapy: A multicohort, open‐label, phase II trial with bi... by Yaxiong Zhang, Zihong Chen, Yu Liu, Liang Han, Wei Jiang, Qiming Wang, Jianhua Shi, Liqin Lu, Jianying Li, Mingjun Zhang, Yan Huang, Yunpeng Yang, Xue Hou, Li Zhang, Jing Li, Wenfeng Fang, Gang Chen

“…Biomarker analysis revealed that patients with high‐level HDAC2 expression had numerically superior ORR (4.3% vs. 0), DCR (52.2% vs. 0) and mPFS (3.7 vs. 1.4m). Patients with negative PD‐L1 had numerically superior DCR (52.2% vs. 33.3%) and mPFS (3.7m vs. 1.8m), so were those with low‐level bTMB (DCR: 59.1% vs. 16.7%, mPFS: 3.8 vs.1.9m). …”
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Clinical characterization and placental pathology of mpox infection in hospitalized patients in the Democratic Republic of the Congo. by Phillip R Pittman, James W Martin, Placide Mbala Kingebeni, Jean-Jacques Muyembe Tamfum, Gaston Mwema, Qingwen Wan, Pierre Ewala, Jules Alonga, Guy Bilulu, Mary G Reynolds, Xiaofei Quinn, Sarah Norris, Michael B Townsend, Panayampalli S Satheshkumar, James Wadding, Bryony Soltis, Anna Honko, Fernando B Güereña, Lawrence Korman, Kerry Patterson, David A Schwartz, John W Huggins, Kole Human Mpox Infection Study Group

“…All 200 patients had anti-orthopoxvirus IgG Abs; whereas 189/200 were positive for IgM. Patients with hypoalbuminemia had a high risk of severe disease. …”
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4306 Periodontal disease and the oral microbiome in antiretroviral-treated patients with HIV by Medini K Annavajhala, Jayesh G. Shah, Jessica Weidler, Karolina Kister, Ryan T. Demmer, Sunil Wadhwa, Michael T. Yin, Anne-Catrin Uhlemann

“…METHODS/STUDY POPULATION: In an ongoing cohort study we have been recruiting pre- and post-menopausal women with HIV+ on ART for ≥6 months and HIV- controls matched by menopausal status (target n = 30 per arm; currently HIV+: n = 30 post- and 9 pre-M; HIV-: n = 15 post- and 6 pre-M). Patients age <18 or on antibiotics within 3 mos., except prophylaxis, are excluded. …”
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A study of heart rate variability in diabetic mellitus patients by Srinivasa Jayachandra, Satyanath Reddy Kodidala

“…Materials and methods. 41 type 2 M patients and 45 age- and sex-matched controls were included. …”
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Objective biomarkers for clinical relapse in multiple sclerosis: a metabolomics approach by Yeo, T, Probert, F, Sealey, M, Saldana, L, Geraldes, R, Höeckner, S, Schiffer, E, Claridge, TDW, Leppert, D, DeLuca, G, Kuhle, J, Palace, J, Anthony, DC

“…Using supervised multivariate analysis, we found that the global metabolomics profile of R patients was significantly perturbed compared to LR ≥ 24 M patients. Identified discriminatory metabolites were then quantified using targeted metabolomics. …”

The simple and fast swallowing function assessment in acute stroke patients by Taşkin Güneş, Esengül Liman Yazıcı, İrem Baş, Cansu Söylemez, Yüksel Erdal, Ufuk Emre, Esra Akdeniz

“…RESULTS: Seventy-three (26F/47M) patients were included in this study if they were conscious and the Glasgow coma scale was above 10 points. …”
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Lung function and collagen 1a levels are associated with changes in 6 min walk test distance during treatment of TB among HIV-infected adults: a prospective cohort study by Yeonsoo Baik, Pholo Maenetje, Diana Schramm, Caroline Tiemessen, Itai Ncube, Gavin Churchyard, Robert Wallis, Mboyo-di-tamba Vangu, Hardy Kornfeld, Yun Li, Sara C. Auld, Gregory P. Bisson

“…The MCID for change in walk distance was estimated as 41 m. Patients experiencing an MCID on treatment had worse lung function, lower 6 min walk test distance, higher levels of proinflammatory biomarkers including TIMP-1 and M-CSF, and lower levels of collagen 1a at baseline. …”
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Diagnostic efficacy of 18F-FDG PET/CT in patients with adrenal incidentaloma by Gamze Akkuş, Isa Burak Güney, Fesih Ok, Mehtap Evran, Volkan Izol, Şeyda Erdoğan, Yıldırım Bayazıt, Murat Sert, Tamer Tetiker

“…Methods: Total 109 (73 F, 36 M) patients with adrenal mass (incidentaloma), mean age of 53.3 ± 10.2 years (range, 24–70) were screened by 18F-FDG PET/CT. …”
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The Effect of Cold Application to the Lateral Neck Area on Peripheral Vascular Access Pain: A Randomised Controlled Study by Senay Canikli Adıgüzel, Dilan Akyurt, Gökçe Ültan Özgen, Hatice Bahadır Altun, Aleyna Çakır, Mustafa Süren, İsmail Okan

“…Bilateral cold application to the lateral side of the neck was performed prior to the commencement of vascular access in Group M patients, followed by the subsequent opening of vascular access. …”
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The effects of cages implantation on surgical and adjacent segmental intervertebral foramina by Changyan Wu, Xiaojuan Yang, Xu Gao, Liwei Shao, Fang Li, Yunxin Sun, Xiaoyu Liu, Shuaihao Yao, Yifu Sun

“…In accordance with the different ranges of distraction (H/H m), patients were classified into three groups: group A (H/H m<1.20, n=13), group B (1.20≤H/H m≤1.80, n=37), and group C (H/H m>1.80, n=11). …”
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Postural Control in Lowlanders With COPD Traveling to 3100 m: Data From a Randomized Trial Evaluating the Effect of Preventive Dexamethasone Treatment by Lara Muralt, Lara Muralt, Michael Furian, Michael Furian, Mona Lichtblau, Mona Lichtblau, Sayaka S. Aeschbacher, Sayaka S. Aeschbacher, Ross A. Clark, Bermet Estebesova, Bermet Estebesova, Ulan Sheraliev, Ulan Sheraliev, Nuriddin Marazhapov, Nuriddin Marazhapov, Batyr Osmonov, Batyr Osmonov, Maya Bisang, Maya Bisang, Stefanie Ulrich, Stefanie Ulrich, Tsogyal D. Latshang, Tsogyal D. Latshang, Silvia Ulrich, Silvia Ulrich, Talant M. Sooronbaev, Talant M. Sooronbaev, Konrad E. Bloch, Konrad E. Bloch, Konrad E. Bloch

“…Postural control was assessed with a Wii Balance BoardTM at 760 m and 1 day after arrival at 3100 m. Patients were instructed to stand immobile on both legs with eyes open during five tests of 30 s each, while the center of pressure path length (PL) was measured.Results: With ascent from 760 to 3100 m the PL increased in the placebo group from median (quartiles) 29.2 (25.8; 38.2) to 31.5 (27.3; 39.3) cm (P &lt; 0.05); in the dexamethasone group the corresponding increase from 28.8 (22.8; 34.5) to 29.9 (25.2; 37.0) cm was not significant (P = 0.10). …”
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Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States by Li X, Gao Y, Liu Y, Wang Y, Wu Q

“…This retrospective institution-based study aimed to identify simple, rapid, and inexpensive clinical markers of physical violence in patients with BD-M.Patients and Methods: The anonymized sociodemographic variables (sex, age, years of education, marital status) and clinical ones (weight, height, body mass index, blood pressure, the score of BRMS, number of BD episodes, psychotic symptoms, history of violence, biochemical parameters, and blood routine parameters) of 316 BD-M participants were collected, and the risk of physical violence was identified using the Brøset Violence Checklist (BVC). …”
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Respiratory muscle strength effect on linear and nonlinear heart rate variability parameters in COPD patients by Goulart CL, Simon JC, Schneiders PB, San Martin EA, Cabiddu R, Borghi-Silva A, Trimer R, da Silva ALG

“…Results: During the RSA-M, patients presented an HRV power increase in the low-frequency band (LFnu) (46.9&plusmn;23.7 vs 75.8&plusmn;27.2; P=0.01) and a decrease in the high-frequency band (HFnu) (52.8&plusmn;23.5 vs 24.0&plusmn;27.0; P=0.01) when compared to the resting condition. …”
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