Patient Demographic and Clinician Factors in Antibiotic Prescribing for Upper Respiratory Tract Infections in the Australian Capital Territory from 2006-2015 by Hannah Glenn, Justin Friedman, Alexander A. Borecki, Camilla Bradshaw, Nicolas Grandjean-Thomsen, Harrison Pickup, Michelle Yue Yin, Catherine Jun, Mohamed E. Abdel-Latif

Get full text

Integration of clinicopathologic identification and deep transferrable image feature representation improves predictions of lymph node metastasis in prostate cancer by Ying Hou, Jie Bao, Yang Song, Mei-Ling Bao, Ke-Wen Jiang, Jing Zhang, Guang Yang, Chun-Hong Hu, Hai-Bin Shi, Xi-Ming Wang, Yu-Dong Zhang

“…Funding: This work was supported by the Key Research and Development Program of Jiangsu Province (BE2017756) and the Suzhou Science and Technology Bureau-Science and Technology Demonstration Project (SS201808).…”
Get full text

Multi-Parametric Cardiac Magnetic Resonance for Prediction of Heart Failure Death in Thalassemia Major by Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Paolo Ricchi, Calogera Gerardi, Gennaro Restaino, Riccardo Righi, Vincenzo Positano, Filippo Cademartiri

Get full text

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice by Domenico Sergi, Fiona M. Campbell, Christine Grant, Amanda C. Morris, Eva-Maria Bachmair, Christiane Koch, Fiona H. McLean, Aifric Muller, Nigel Hoggard, Baukje de Roos, Begona Porteiro, Mark V. Boekschoten, Fiona C. McGillicuddy, Darcy Kahn, Phyllis Nicol, Jonas Benzler, Claus-Dieter Mayer, Janice E. Drew, Helen M. Roche, Michael Muller, Ruben Nogueiras, Carlos Dieguez, Alexander Tups, Lynda M. Williams

Get full text

Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. A pilot study. by Francesco Marongiu, Dimitrios Marco Ntoukas, Luigi Barberini, Maria Filomena Ruberto, Maria Sebastiana Piras, Maria Conti, Maria Luisa Di Martino, Mario Mura, Silvia Marongiu, Maria Luigia Vannini, Mattia Lillu, Monica Piras, Daniela Fanni, Lara Fenu, Carmen Porcu, Doris Barcellona, Gavino Faa, Terenzio Congiu

Get full text

Ligand-displaying Escherichia coli cells and minicells for programmable delivery of toxic payloads via type IV secretion systems by Yang Grace Li, Kouhei Kishida, Natsumi Ogawa-Kishida, Peter J. Christie

“…ABSTRACT Bacterial type IV secretion systems (T4SSs) are highly versatile macromolecular translocators and offer great potential for deployment as delivery systems for therapeutic intervention. One major T4SS subfamily, the conjugation machines, are well-adapted for delivery of DNA cargoes of interest to other bacteria or eukaryotic cells but generally exhibit modest transfer frequencies and lack specificity for target cells. …”
Get full text

Nephrological Complications in Hemoglobinopathies: SITE Good Practice by Giovan Battista Ruffo, Rodolfo Russo, Tommaso Casini, Letizia Lombardini, Valeria Orecchia, Vincenzo Voi, Raffaella Origa, Gian Luca Forni, Monia Marchetti, Antonia Gigante, Giacomo Garibotto, Aurelio Maggio, Lucia De Franceschi

Get full text

Health behaviour, social support, socio-economic status and the 5-year progression of multimorbidity: Results from the MultiCare Cohort Study by Ingmar Schäfer, Heike Hansen, Hanna Kaduszkiewicz, Horst Bickel, Angela Fuchs, Jochen Gensichen, Wolfgang Maier, Steffi G Riedel-Heller, Hans-Helmut König, Anne Dahlhaus, Gerhard Schön, Siegfried Weyerer, Birgitt Wiese, Hendrik van den Bussche, Martin Scherer

“…Results: Regarding cardiovascular and metabolic diseases, multimorbidity progressed more rapidly in patients who reported less physical activity ( ß = −0.28; 95% confidence interval = −0.35 to −0.20), had more tobacco-related pack years (0.15; 0.07–0.22) and consumed less alcohol (−0.21; −0.31 to −0.12) at baseline. …”
Get full text

FANCI serve as a prognostic biomarker correlated with immune infiltrates in skin cutaneous melanoma by Zhenguo Cai, Zhenguo Cai, Yanjuan Duan, Wen Li, Zhuohang Liu, Zijun Gong, Sheng Hong, Xu He, Xinyang Xuanyuan, Youdong Chen, Xinling Bi, Wuqing Wang

“…Finally, this study analyzed the correlation of FANCI and tumor-infiltrating immune cells by CIBERSORT, ESTIMATE, and ssGSEA algorithms.ResultsThe FANCI level was increasing in SKCM tissues from GSE46517, GSE15605, GSE114445, and TCGA-SKCM. …”
Get full text

Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma by Weidong Chen, Yan Liao, Pengxiao Sun, Jian Tu, Yutong Zou, Ji Fang, Ziyun Chen, Hongbo Li, Junkai Chen, Yuzhong Peng, Lili Wen, Xianbiao Xie

“…The “ESTIMATE” package and ssGSEA algorithm were utilized to evaluate the differences in immune cells infiltration between the groups. …”
Get full text

Beta-Blocker and Renin–Angiotensin System Inhibitor Combination Therapy in Patients with Acute Myocardial Infarction and Prediabetes or Diabetes Who Underwent Successful Implantati... by Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang

“…Long-term clinical outcomes in patients with acute myocardial infarction (AMI) and prediabetes or diabetes who received ß-blockers (BB) and renin–angiotensin system inhibitor (RASI) therapy after successful newer-generation drug-eluting stent (DES) implantation are limited. …”
Get full text

Online Learning Self-Efficacy during an Emergent Transition: A Cross-sectional Survey among Undergraduate Students in Saudi Arabia by MATHAR MOHIDEEN NAGOOR THANGAM, AHLAM ALATAWI, AHOUD ALBALAWI, ASHJAN ALJUHANI, EMAN ALBALAWI, TAIF ALBALAWI

Get full text

Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension by David Fouassier, Anne Blanchard, Antoine Fayol, Guillaume Bobrie, Pierre Boutouyrie, Michel Azizi, Jean‐Sébastien Hulot

“…In multivariable linear regression analyses, NBD treatment was significantly associated with decreased BNP levels (adjusted ß: −46.41 ± 6.99, P < 0.0001) independent of age, gender, renal function, and changes in BPs or heart rate. …”
Get full text

Evaluating GRACE Mass Change Time Series for the Antarctic and Greenland Ice Sheet—Methods and Results by Andreas Groh, Martin Horwath, Alexander Horvath, Rakia Meister, Louise Sandberg Sørensen, Valentina R. Barletta, René Forsberg, Bert Wouters, Pavel Ditmar, Jiangjun Ran, Roland Klees, Xiaoli Su, Kun Shang, Junyi Guo, C. K. Shum, Ernst Schrama, Andrew Shepherd

Get full text

Use of MALDI-TOF MS to Discriminate between Aflatoxin B1-Producing and Non-Producing Strains of <i>Aspergillus flavus</i> by Lukas Hleba, Miroslava Hlebova, Anton Kovacik, Jana Petrova, Zuzana Maskova, Juraj Cubon, Peter Massanyi

Get full text

Clinicopathological Study of Ovarian Germ Cell Tumours in Tertiary Care Hospital, Tamil Nadu, India: A cross-sectional Study by V LOKESHWARI, PI OSHIN, M GOMATHI, V ESWARI

Get full text

Clinico-aetiological Profile and Outcome of Hypernatremic Dehydration in Term Neonates Admitted to the NICU at a Tertiary Care Centre in Udaipur, Rajasthan, India by Sanchi Gagneja, Dileep Goyal, Hemlata Mittal, Savita Shekhawat, Devendra Sareen, Sukhanwar Sing Sandhu

Get full text

Evaluation of Clinical and Pathological Response in Breast Cancer Following Neoadjuvant Chemotherapy- A Single Institution Experience by Anju Farzana Abdul Gafoor, Priya Balakrishnan, KM Jagathnath Krishna, Asha Arjunan

Get full text

Identification of Angiogenesis-Related Prognostic Biomarkers Associated With Immune Cell Infiltration in Breast Cancer by Dan Tao, Dan Tao, Ying Wang, Xin Zhang, Can Wang, Dingyi Yang, Jing Chen, Yanyan Long, Yong Jiang, Xian Zhou, Ningning Zhang

“…GO, KEGG pathway, and GSEA were used to investigate the biological functions of differentially expressed genes (DEGs), and CIBERSORT, ssGSEA, and xCell algorithms were performed to estimate the ICI in high-risk and low-risk groups. …”
Get full text

New characterization of dihydroergotamine receptor pharmacology in the context of migraine: utilization of a β-arrestin recruitment assay by Lisa McConnachie, Lisa McConnachie, Peter J. Goadsby, Peter J. Goadsby, Robert E. Vann, Sutapa Ray, Stephen B. Shrewsbury, Sheena K. Aurora

“…Knowledge of DHE pharmacology largely comes from studies employing older methodologies.ObjectiveTo assess DHE receptor activity using high-throughput methods to screen for functional ß-arrestin activity at G protein–coupled receptors (GPCRs).MethodsFunctional receptor activities of DHE and sumatriptan succinate (both 10 μM) were screened against 168 GPCRs using the gpcrMAX assay. …”
Get full text