Co‐occurrence of breast cancer and neuroendocrine tumours: New genetic insights beyond Multiple Endocrine Neoplasia syndromes by Vincent Larouche, Amit Akirov, Emily Thain, Raymond H. Kim, Shereen Ezzat

“…A third patient was found to carry a pathogenic variant in PALB2 as well as a VUS in FANCM, MLH1 and STK11. Another patient was found to harbour a VUS in MSH2. …”
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Pancancer analysis of a potential gene mutation model in the prediction of immunotherapy outcomes by Lishan Yu, Lishan Yu, Caifeng Gong

“…The desired signature named SIGP was the risk score of the model and was validated in the remaining 20% of patients and an external ICB-treated cohort (n = 249) from DFCI.Results: SIGP was based on 18 candidate genes (NOTCH3, CREBBP, RNF43, PTPRD, FAM46C, SETD2, PTPRT, TERT, TET1, ROS1, NTRK3, PAK7, BRAF, LATS1, IL7R, VHL, TP53, and STK11), and we classified patients into SIGP high (SIGP-H), SIGP low (SIGP-L) and SIGP wild type (SIGP-WT) groups according to the SIGP score. …”
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The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma by Shane Brennan, Anne-Marie Baird, Esther O’Regan, Orla Sheils

“…Somatic mutations in TSC2, BRIP1, NBN, TACC3, NFE2l2, STK11, HRAS, PIK3R1, TP63, and FAT1 have been identified in recurrent HPV positive OPSCC. …”
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Recent progress in targeted therapy for non-small cell lung cancer by Yanxia Xiao, Pu Liu, Jie Wei, Xin Zhang, Jun Guo, Yajun Lin, Yajun Lin

“…This review describes the mechanisms of targeted-drug resistance and newly identified non-small cell lung cancer targets (e.g., KRAS G12C, NGRs, DDRs, CLIP1-LTK, PELP1, STK11/LKB1, NFE2L2/KEAP1, RICTOR, PTEN, RASGRF1, LINE-1, and SphK1). …”
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KRAS in NSCLC: State of the Art and Future Perspectives by Priscilla Cascetta, Arianna Marinello, Chiara Lazzari, Vanesa Gregorc, David Planchard, Roberto Bianco, Nicola Normanno, Alessandro Morabito

“…KRAS mutations often concur with other molecular alterations, notably TP53, STK11, and KEAP1, which could play an important role in treatment efficacy and patient outcomes. …”
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Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy by Xiao-dan Liu, Yan Zhang, Hui-ying He

“…Significant differences can be found in the mutation rate of EGFR (60.9% vs 11.9%), KRAS (12.2% vs 25.0%), STK11 (1.5% vs 11.9%), FGFR3 (2.4% vs 0.0%) and ERBB4 (1.2% vs 6.1%) between adenocarcinoma in our cohort and TCGA-LUAD data (all p < 0.001). …”
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Disease spectrum of gastric cancer susceptibility genes by McKinley, Sophia K., Singh, Preeti, Yin, Kanhua, Wang, Jin, Zhou, Jingan, Bao, Yujia, Wu, Menghua, Pathak, Kush, Mullen, John T., Braun, Danielle, Hughes, Kevin S.

“…Out of 27 candidate genes, 13 were identified as gastric cancer susceptibility genes (APC, ATM, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH-Biallelic, PALB2, SMAD4, and STK11). A total of 145 gene–disease associations (with 45 unique diseases) were found to be associated with these 13 genes. …”
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Disease spectrum of gastric cancer susceptibility genes by McKinley, Sophia K, Singh, Preeti, Yin, Kanhua, Wang, Jin, Zhou, Jingan, Bao, Yujia, Wu, Menghua, Pathak, Kush, Mullen, John T, Braun, Danielle, Hughes, Kevin S

“…Out of 27 candidate genes, 13 were identified as gastric cancer susceptibility genes (APC, ATM, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH-Biallelic, PALB2, SMAD4, and STK11). A total of 145 gene–disease associations (with 45 unique diseases) were found to be associated with these 13 genes. …”
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Genetic Profile of Young Chinese Patients with Lung Adenocarcinoma by Yu LIANG, Helei HOU, Man JIANG, Chuantao ZHANG, Dong LIU, Xiaochun ZHANG

“…However, a reverse trend was observed for kirsten rat sarcoma viral oncogene (KRAS), serine/threonine kinase 11 (STK11) and epidermal growth factor receptor (EGFR) exon 20 mutations, which were more frequently identified in the older group, aged more than 45 years. …”
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Exploring potential molecular resistance and clonal evolution in advanced HER2-positive gastric cancer under trastuzumab therapy by Qi Xu, Xiaoqing Xu, Haimeng Tang, Junrong Yan, Jingjing Li, Hua Bao, Xue Wu, Yang Shao, Cong Luo, Haimin Wen, Jianying Jin, Jieer Ying

“…In our cohort, the most common genes to acquire mutations are AURKA, MYC, STK11, and LRP6 with four patients each. We also discovered an association between clonal branching pattern and survival, with an extensive clonal branching pattern being more closely related to a shorter PFS than other branching patterns (HR = 4.71; P = 0.008). …”
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Case Report: A Squamous Cell Lung Carcinoma Patient Who Responded to Neoadjuvant Immunochemotherapy but Died From Anastomosis Leakage or/and irAEs: Immune Microenvironment and Geno... by Liping Hao, Ying Hu, Jianjun Hu, Yang Liu, Beibei Mao, Huan Chen, Xiaoli Gong, Di Wang, Lin Wang, Dong Wang

“…In the pretreatment tumor biopsy, PD-L1 expression was negative and a few T cells, NK cells, and macrophages had infiltrated the tumor. Wild-type EGFR/STK11, mutant TP53, microsatellite stability, and low tumor mutational burden were also found at baseline. …”
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Genomic landscape of lung adenocarcinomas in different races by Huashan Shi, Karan Seegobin, Fei Heng, Kexun Zhou, Ruqin Chen, Hong Qin, Rami Manochakian, Yujie Zhao, Yanyan Lou

“…Whites (17.2%), Blacks (15.1%), and Other (15.7%) had higher rates of STK11 mutation than Asians (3.94%) (P&lt;0.001). …”
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Peutz-Jeghers syndrome a review of gynecological implications and the management of these patients through the presentation of a case report by Katarzyna Plagens-Rotman, Grażyna Jarząbek-Bielecka, Piotr Merks, Katarzyna Wróblewska-Seniuk, Małgorzata Mizgier, Ewa Jakubek, Samuel Grześkiewicz, Małgorzata Wójcik, Witold Kędzia

“…Background: Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant genetic condition caused by mutations in STK11 (Serine/threonine kinase 11) gene (OMIM 602216 Serine/Threonine Protein Kinase 11) located in the short arm of chromosome 19 (19p.13.3). …”
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Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons by Jordan D. Frey, MD, Ara A. Salibian, MD, Freya R. Schnabel, MD, Mihye Choi, MD, Nolan S. Karp, MD

“…Included in this review are syndromic breast cancer susceptibility genes such as TP53, PTEN, CDH1, and STK11, among others. Nonsyndromic breast cancer susceptibility genes herein reviewed include PALB2, CHEK2, and ataxia telangiectasia mutated gene. …”
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Clinicopathological characteristics and treatment outcomes of advanced SMARCA4‐deficient thoracic tumors by Anni Wang, Yueping Jin, Zhengqi Cao, Li Lu, Ziming Li

“…The most common genetic mutations identified via NGS included TP53, CDKN2A, KRAS, STK11, NF1, and PTEN. No significant overall survival (OS) difference was observed between SMARCA4‐NSCLCs and SMARCA4‐UTs (p = 0.366). …”
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Genomic Landscape of Endometrial, Ovarian, and Cervical Cancers in Japan from the Database in the Center for Cancer Genomics and Advanced Therapeutics by Qian Xi, Hidenori Kage, Miho Ogawa, Asami Matsunaga, Akira Nishijima, Kenbun Sone, Kei Kawana, Katsutoshi Oda

“…Among the 839 cervical cancer samples, frequent mutations of <i>KRAS</i>, <i>TP53</i>, <i>PIK3CA</i>, <i>STK11</i>, <i>CDKN2A</i>, and <i>ERBB2</i> were observed in adenocarcinomas, whereas the ratio of TMB-H was significantly higher in squamous cell carcinomas. …”
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Breaking the ‘Undruggable’ Barrier: Anti-PD-1/PD-L1 Immunotherapy for Non-Small Cell Lung Cancer Patients with <i>KRAS</i> Mutations—A Comprehensive Review and Description of Singl... by Izabela Chmielewska, Paweł Krawczyk, Anna Grenda, Magdalena Wójcik-Superczyńska, Natalia Krzyżanowska, Michał Gil, Janusz Milanowski

“…However, some studies have suggested a lower response rate to immunotherapy in KRAS-mutated NSCLC patients with the coexistence of mutations in the <i>STK11</i> (<i>Serine</i>/<i>Threonine Kinase 11</i>) gene. …”
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Prognostic Significance of Iron Metabolism Related Genes in Human Lung Adenocarcinoma by Li P, Wu X, Chen P, Gu Z

“…The expression of STEAP1 and STEAP2 was not only negatively correlated with the trafficking degree of CD4+ T immune cells and positively related to most immune cells’ trafficking degree, but also significantly associated with gene mutation status, particularly with mutations on TP53 and STK11. Four types of drug resistance showed significant correlation with the expression level of STEAP1 while 13 types of drug resistance were associated with the expression level of STEAP2.Conclusion: Multiple iron metabolism related genes including STEAP1 and STEAP2 are significantly associated with the prognosis of LUAD patients. …”
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LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases by Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang

“…Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes, such as cell polarity, cell cycle arrest, embryo development, apoptosis, and bioenergetics metabolism. …”
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Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer by Kawmadi Gunawardena, Nirmala D. Sirisena, Gayani Anandagoda, Nilaksha Neththikumara, Vajira H.W. Dissanayake

“…Distribution of VUS in breast cancer predisposing genes were :APC:1(5.8%), ATM:2(11.7%), BRCA 1:1(5.8%), BRCA 2:5(29.4%), BRIP 1:1(5.8%), CDKN 2A:1(5.8%), CHEK 2:2(11.7%), FANC 1:1(5.8%), MET:1(5.8%), STK 11:1(5.8%), NF 2:1(5.8%). Mean age at cancer diagnosis in patients with VUS was 51.2 years. …”
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