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Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China
Published 2017-01-01“…Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system. …”
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Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
Published 1999“…Germline mutations in the LKB1/STK11 serine/threonine kinase cause Peutz-Jeghers syndrome and this gene is also mutated at a moderate frequency in a wide variety of sporadic tumours. …”
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The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome
Published 2018-08-01Subjects: Get full text
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Deleterious mis‐splicing of STK11 caused by a novel single‐nucleotide substitution in the 3′ polypyrimidine tract of intron five
Published 2020-09-01Subjects: Get full text
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Using High Resolution Melting method for detecting nucleotide polymorphisms of STK11 gene germline in patients with digestive system cancers
Published 2017-11-01Subjects: “…Keywords: STK11 gene, mutation of germline, high resolution melting…”
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The prognostic impact of KRAS, TP53, STK11 and KEAP1 mutations and their influence on the NLR in NSCLC patients treated with immunotherapy
Published 2023-01-01Subjects: Get full text
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Using High Resolution Melting Method for Detecting Nucleotide Polymorphisms of STK11 Gene Germline in Patients with Digestive System Cancers
Published 2016-06-01Subjects: “…stk11 gene, mutation of germline, high resolution melting…”
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Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory
Published 2020-08-01Subjects: “…Stk11…”
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Malignant STK11 adnexal tumor harboring a somatic mutation in a woman previously diagnosed with mesothelioma, a case report
Published 2024-12-01Subjects: Get full text
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The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients
Published 2023-03-01Subjects: Get full text
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Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification
Published 2022-04-01“…Here the authors show STK11IP is a substrate of mTORC1 that regulates lysosomal acidification through V-ATPase and represses autophagy.…”
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A novel <it>de novo </it>mutation in the serine-threonine kinase <it>STK11 </it>gene in a Korean patient with Peutz-Jeghers syndrome
Published 2008-05-01“…Germline mutation of the <it>STK11 </it>gene, which encodes a serine-threonine kinase, is responsible for PJS.…”
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Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation
Published 2023-09-01“…We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. …”
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Effects of KRAS, STK11, KEAP1, and TP53 mutations on the clinical outcomes of immune checkpoint inhibitors among patients with lung adenocarcinoma.
Published 2024-01-01“…Patients with STK11, KEAP1, or TP53 mutations had a significantly greater TMB (P<0.001). …”
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Case report: Therapeutic response of front-line cadonilimab plus chemotherapy on patient with advanced lung adenocarcinoma harboring STK11 genetic aberration
Published 2024-12-01Subjects: “…STK11 mutation…”
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