Family with Peutz–Jeghers syndrome in Indonesia by Muhammad Luthfi Parewangi, Resha Dermawansyah Rusman, Fardah Akil, Nu'man A S Daud, Rini Bachtiar, Susanto Hendra Kusuma, Amelia Rifai, Akiko Syawalidhany Tahir, Upik Miskad, Erwin Syarifuddin

“…All three had mutations in the serine/threonine kinase 11 gene (STK11).…”
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Metachronous and Synchronous Occurrence of 5 Primary Malignancies in a Female Patient between 1997 and 2013: A Case Report with Germline and Somatic Genetic Analysis by Jenny Nyqvist, Fredrik Persson, Toshima Z. Parris, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Åke Borg, Per Karlsson, Anikó Kovács

“…Interestingly, next-generation sequencing analysis of the patient’s blood sample detected no mutations in the BRCA1, BRCA2, TP53, PTEN, CDH1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, STK11, BMPR1A, SMAD4, PTEN, POLE, POLD1, GREM1, and GALNT12 genes. …”
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Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours. by Wang, Z, Churchman, M, Campbell, I, Xu, W, Yan, Z, McCluggage, W, Foulkes, W, Tomlinson, I

“…Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. …”

The validation and clinical implementation of BRCAplus: a comprehensive high-risk breast cancer diagnostic assay. by Hansook Kim Chong, Tao Wang, Hsiao-Mei Lu, Sara Seidler, Hong Lu, Steven Keiles, Elizabeth C Chao, A J Stuenkel, Xiang Li, Aaron M Elliott

“…The NGS based BRCAplus test utilizes a custom tiled PCR based target enrichment design and bioinformatics pipeline coupled with array comparative genomic hybridization (aCGH) to identify mutations in the six high-risk genes: BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11. Validation of the assay with 250 previously characterized samples resulted in 100% detection of 3,025 known variants and analytical specificity of 99.99%. …”
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Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test? by Francesca Rebuzzi, Paola Ulivi, Gianluca Tedaldi

“…However, some other genetic disorders confer an increased risk of colorectal cancer, such as Li–Fraumeni syndrome (<i>TP53</i> gene), <i>MUTYH</i>-associated polyposis (<i>MUTYH</i> gene), Peutz–Jeghers syndrome (<i>STK11</i> gene), Cowden syndrome (<i>PTEN</i> gene), and juvenile polyposis syndrome (<i>BMPR1A</i> and <i>SMAD4</i> genes). …”
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Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma by Delgado TC, Lopitz-Otsoa F, Martínez-Chantar ML

“…Teresa Cardoso Delgado, Fernando Lopitz-Otsoa, Mar&iacute;a Luz Mart&iacute;nez-ChantarLiver Disease and Liver Metabolism Laboratories, CIC bioGUNE, Centro de Investigaci&oacute;n Biom&eacute;dica en Red de Enfermedades Hep&aacute;ticas y Digestivas (CIBERehd), Derio 48160, Bizkaia, SpainAbstract: Liver kinase B1 (LKB1) also referred to as serine/threonine kinase 11 (STK11) encodes a 50 kDa evolutionary conserved serine/threonine kinase that is ubiquitously expressed in adult and fetal tissues. …”
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Targeting immune cell types of tumor microenvironment to overcome resistance to PD-1/PD-L1 blockade in lung cancer by Man Wang, Lijie Zhu, Xiaoxu Yang, Jiahui Li, Yu’e Liu, Ying Tang

“…Moreover, we describe the efficacy of immunotherapy in driven gene mutations in lung cancer, including KRAS, TP53, EGFR, ALK, ROS1, KEAP1, ZFHX3, PTCH1, PAK7, UBE3A, TNF-α, NOTCH, LRP1B, FBXW7, and STK11. We also emphasize that modulation of immune cell types of TME could be a promising strategy for improving adaptive immune resistance in lung cancer.…”
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DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. by Kimberly D Siegmund, Caroline M Connor, Mihaela Campan, Tiffany I Long, Daniel J Weisenberger, Detlev Biniszkiewicz, Rudolf Jaenisch, Peter W Laird, Schahram Akbarian

“…A robust and progressive rise in DNA methylation levels across the lifespan was observed for 8/50 loci (GABRA2, GAD1, HOXA1, NEUROD1, NEUROD2, PGR, STK11, SYK) typically in conjunction with declining levels of the corresponding mRNAs. …”
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High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer. by Seokhwi Kim, Jeeyun Lee, Min Eui Hong, In-Gu Do, So Young Kang, Sang Yun Ha, Seung Tae Kim, Se Hoon Park, Won Ki Kang, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Duk-Hwan Kim, Kyoung-Mee Kim

“…Frequently detected somatic mutations included TP53 (28.17%), APC (10.1%), PIK3CA (5.6%), KRAS (4.5%), SMO (3.4%), STK11 (3.4%), CDKN2A (3.4%) and SMAD4 (3.4%). Amplifications of HER2, CCNE1, MYC, KRAS and EGFR genes were observed in 8 (8.9%), 4 (4.5%), 2 (2.2%), 1 (1.1%) and 1 (1.1%) cases, respectively. …”
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Novel Genetic Causes of Gastrointestinal Polyposis Syndromes by Jelsig AM, Byrjalsen A, Busk Madsen M, Kuhlmann TP, van Overeem Hansen T, Wadt KAW, Karstensen JG

“…While the genes responsible for some of the syndromes, eg, APC in familial adenomatous polyposis and STK11 in Peutz-Jeghers syndrome, have been known for decades, novel genetic causes have recently been detected that have shed light on the broader clinical spectrum of syndromes. …”
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Targeting PGM3 as a Novel Therapeutic Strategy in <i>KRAS/LKB1</i> Co-Mutant Lung Cancer by Hyunmin Lee, Feng Cai, Neil Kelekar, Nipun K. Velupally, Jiyeon Kim

“…In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene <i>KRAS</i> and tumor suppressor <i>STK11</i> (also known as LKB1) confer an aggressive malignant phenotype, an unfavourability towards immunotherapy, and overall poor prognoses in patients. …”
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Effects of Using Lipsticks with any Lead Content on the BRCA1 Gene Mutations by Fatemeh Roudbai, Zeinab Khalili, Mojtaba Mohseni

“…Variations in the BRCA1, BRCA2, CDH1, STK11 and TP53 genes increase the risk of developing breast cancer. …”
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The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice by Sagen Zac-Varghese, Stefan Trapp, Paul Richards, Sophie Sayers, Gao Sun, Stephen R. Bloom, Frank Reimann, Fiona M. Gribble, Guy A. Rutter

“…Liver kinase B1 (LKB1; also known as STK11) is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS), a premalignant syndrome associated with the development of gastrointestinal polyps. …”
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If Virchow and Ehrlich Had Dreamt Together: What the Future Holds for <i>KRAS</i>-Mutant Lung Cancer by Jens Köhler, Pasi A. Jänne

“…This strategy is supported by preclinical models which show that <i>KRAS</i>(G12C) inhibitors can turn some immunologically “cold” tumors into “hot” ones and therefore could benefit patients whose tumors harbor subtype-defining STK11/LKB1 co-mutations. Forty years after the discovery of <i>KRAS</i> as a transforming oncogene, we are on the verge of approval of the first <i>KRAS</i>-targeted drug combinations, thus therapeutically unifying Paul Ehrlich’s century-old “magic bullet” vision with Rudolf Virchow’s cancer inflammation theory.…”
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Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication. by Krishna C Vallabhaneni, Meeves-Yoni Hassler, Anu Abraham, Jason Whitt, Yin-Yuan Mo, Azeddine Atfi, Radhika Pochampally

“…Changes in the expression levels of focal adhesion kinase, STK11 were confirmed by quantitative PCR assays. …”
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Selective gene expression profiling of mTOR-associated tumor suppressor and oncogenes in ovarian cancer by Lech Chyczewski, Jacek Szamatowicz, Radosław Charkiewicz, Włodzimierz Baranowski, Magdalena Garbowicz, Dominik Rysak-Luberowicz, Tomasz Milczek, Dagmara Klasa-Mazurkiewicz, Oksana Kowalczuk, Piotr Laudański

“…The array was custom-designed to include the following genes: NF1, RHEB, mTOR1, AKT-1, PTEN, TSC1, TSC2, KRAS, RPS6KB1, 4EBP1, TP53, EIF4E, STK11, PIK3CA and BECN1. Confirmatory immunohistochemical detection was performed for a group of selected proteins. …”
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Comprehensive mutation analysis in colorectal flat adenomas. by Quirinus J M Voorham, Beatriz Carvalho, Angela J Spiertz, Bart Claes, Sandra Mongera, Nicole C T van Grieken, Heike Grabsch, Martin Kliment, Bjorn Rembacken, Mark A van de Wiel, Philip Quirke, Chris J J Mulder, Diether Lambrechts, Manon van Engeland, Gerrit A Meijer

“…In the present study, we aimed to compare the mutation spectrum of 14 cancer genes, between these two phenotypes.A consecutive series of 106 flat and 93 polypoid adenomas was analyzed retrospectively for frequently occurring mutations in "hot spot" regions of KRAS, BRAF, PIK3CA and NRAS, as well as selected mutations in CTNNB1 (β-catenin), EGFR, FBXW7 (CDC4), PTEN, STK11, MAP2K4, SMAD4, PIK3R1 and PDGFRA using a high-throughput genotyping technique. …”
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Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions by Morgan Claire C, Shakya Kabita, Webb Andrew, Walsh Thomas A, Lynch Mark, Loscher Christine E, Ruskin Heather J, O’Connell Mary J

“…Lineage-specific positive selection was detected in the ancestral Euarchontoglires and Hominidae lineages for STK11, in the ancestral primate lineage for CDH1, in the ancestral Murinae lineage for both SDHC and MSH6 genes and the ancestral Muridae lineage for TSC1.…”
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High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma. by Jeeyun Lee, Paul van Hummelen, Christina Go, Emanuele Palescandolo, Jiryeon Jang, Ha Young Park, So Young Kang, Joon Oh Park, Won Ki Kang, Laura MacConaill, Kyoung-Mee Kim

“…Among mutations we screened, PIK3CA mutations were the most frequent (5.1%) followed by p53 (4.6%), APC (2.5%), STK11 (2.1%), CTNNB1 (1.7%), and CDKN2A (0.8%). Six samples harbored concomitant somatic mutations. …”
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LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. by Volikos, E, Robinson, J, Aittomäki, K, Mecklin, J, Järvinen, H, Westerman, A, de Rooji, F, Vogel, T, Moeslein, G, Launonen, V, Tomlinson, I, Silver, A, Aaltonen, L

“…BACKGROUND: LKB1/STK11 germline mutations cause Peutz-Jeghers syndrome (PJS). …”