Mutations in <it>STK11 </it>gene in Czech Peutz-Jeghers patients by Křepelová Anna, Roubalík Jan, Puchmajerová Alena, Vasovčák Peter

“…The germline mutations in the serine/threonine kinase 11 (<it>STK11</it>) gene have been shown to be associated with the disease. …”
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Tumor loss-of-function mutations in STK11/LKB1 induce cachexia by Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante

“…Mutational analysis of circulating tumor DNA from patients with NSCLC identified 89% concordance between STK11/LKB1 mutations and weight loss at cancer diagnosis. …”
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Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients. by Wang, Z, Churchman, M, Avizienyte, E, McKeown, C, Davies, S, Evans, D, Ferguson, A, Ellis, I, Xu, W, Yan, Z, Aaltonen, L, Tomlinson, I

“…Germline mutations of the LKB1 (STK11) serine/threonine kinase gene (chromosome 19p13.3) cause Peutz-Jeghers syndrome, which is characterised by hamartomas of the gastrointestinal tract and typical pigmentation. …”

The role of LKB1 (STK11) in non-small cell lung cancer by Cahill, F

Subjects: “…STK11…”

Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz–Jeghers syndrome by Jy-Ming Chiang, Tse-Ching Chen

“…The entire coding sequence of the STK11 gene was amplified and analyzed by sequencing using the genomic DNA. …”
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275 Translational endpoints associated with STK11 mutations in patients with non-squamous NSCLC by Carl Barrett, Maria Ascierto, Song Wu, Nathan Standifer, Melissa de los Reyes, Micheal Oberst, Rajv Raja

The pattern of STK11 gene mutation and its phenotypical manifestation in patient with hamartomas polyposis by M. R. Lozynska, A. Plawski, I. V. Khavunka, N. M. Fomenko, L. Y. Lozynska

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Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing by Mojgan ATAEI-KACHOUEI, Javad NADAF, Mohammad Taghi AKBARI, Morteza ATRI, Jacek MAJEWSKI, Yasser RIAZALHOSSEINI, Masoud GARSHASBI

“…Keywords: BRCA2, Familial breast cancer, rs80359352, STK11, Iran…”
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Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer by Shuman Zhang, Duo Yun, Hao Yang, Markus Eckstein, Gihan Daw Elbait, Yaxing Zhou, Yanxi Lu, Hai Yang, Jinping Zhang, Isabella Dörflein, Nathalie Britzen-Laurent, Susanne Pfeffer, Marc P. Stemmler, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Hang He, Siyuan Zeng, Bin Lan, Benjamin Frey, Chuanpit Hampel, Eva Lentsch, Paradesi Naidu Gollavilli, Christian Büttner, Arif B. Ekici, Andrew Biankin, Regine Schneider-Stock, Paolo Ceppi, Robert Grützmann, Christian Pilarsky

“…PDE4 inhibitor Roflumilast inhibited STK11-KO cell migration and tumor size, further demonstrating that PDEs are essential for STK11-deficient cell migration. …”
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Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants through Conformational Sampling Approach by Merlin Lopus, D. Meshach Paul, R. Rajasekaran

“…Tumor suppressor gene, STK11 , encodes for serine-threonine kinase, which has a critical role in regulating cell growth and apoptosis. …”
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Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach by Merlin Lopus, D. Meshach Paul, R. Rajasekaran

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A novel mutation in <it>STK11 </it>gene is associated with Peutz-Jeghers Syndrome in Indian patients by Singh Lalji, Mohankrishna P, Rao G, Reddy D, Thakur Nikita, Chandak Giriraj R

“…However, <it>STK11 </it>mutations do not explain all PJS cases. …”
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A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients by Wang Zhiqing, Chen Yulan, Wu Baoping, Zheng Haoxuan, He Jiman, Jiang Bo

“…The entire coding region of the STK11 gene was amplified by polymerase chain reaction and analyzed by direct sequencing.…”
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Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer by XIA Siyu, ZHAO Zitong, LI Li

Subjects: “…stk11…”
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Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. by Lim, W, Hearle, N, Shah, B, Murday, V, Hodgson, S, Lucassen, A, Eccles, D, Talbot, I, Neale, K, Lim, A, O'Donohue, J, Donaldson, A, Macdonald, R, Young, I, Robinson, M, Lee, P, Stoodley, B, Tomlinson, I, Alderson, D, Holbrook, A, Vyas, S, Swarbrick, E, Lewis, A, Phillips, R, Houlston, R

“…Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a rare dominant disorder. …”

STK11 mutation impacts CD1E expression to regulate the differentiation of macrophages in lung adenocarcinoma by Qingfeng Zhang, Juan Feng, Kui Liu, Xiaoyan Yang, Yun Huang, Bo Tang

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Everolimus plus anastrozole for female adnexal tumor of probable Wolffian origin (FATWO) with STK11 mutation by Maria de Pilar Estevez-Diz, Renata Colombo Bonadio, Filomena Marino Carvalho, Jesus Paula Carvalho

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A novel pathogenic splice site variation in STK11 gene results in Peutz–Jeghers syndrome by Na Zhao, Huizhi Wu, Ping Li, Yuxian Wang, Li Dong, Han Xiao, Changxin Wu

“…Abstract Background Peutz–Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disease resulting in multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of various types of cancer, and is caused by variations in the serine/threonine protein kinase STK11 (LKB1). Methods STK11 gene variations were identified by analyzing STK11 cDNA and genomic DNA. …”
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A novel missense mutation of the STK11 gene in a Chinese family with Peutz-Jeghers syndrome by Zhen Yu, Lin Liu, Fang Jiang, Yimin Ji, Xiao Wang, Lili Liu

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STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors by Yohei Kojima, Kouki Ohtsuka, Shun Ishii, Nobuyoshi Aso, Atsuko Ohki, Yoshikazu Hashimoto, Hirohisa Takeuchi, Hiroaki Ohnishi, Nobutsugu Abe

Subjects: “…stk11…”
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