Effect of Microgravity on Human T Lymphocyte Activation: Experiments in Spacelab and Sounding Rockets by A. Cogoli, M. Cogoli-Greuter, M. A. Meloni, G. Galleri, P. Pippia

“… Several physiological systems are altered by the environment of spaceflight.The results of an experiment carried out in Spacelab-1 have surprisingly shown that the mitogenic activation with Concanavalin A (Con A) of T lymphocytes is nearly completely inhibited (by more than 95%) in microgravity conditions [1].We have investigated the causes of the phenomenon in a series of studies performed in the last 15 years in 6 Spacelab missions (D-1 in 1985, SLS-1 in 1991, IML-1 in 1992, IML-2 in 1994 and dramatic STS-107 in 2003), in sounding rockets (6 missions) and in ground-based simulations in the clinostat. …”
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Accidents, engineering and history at NASA: 1967-2003 by Brown, Alexander F. G. (Alexander Frederic Garder), 1970-

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