Isolation of Individual Compounds from the Aerial Part of <i>Comarum palustre </i>L. and Their Structure Elucidation Using Spectroscopic Methods by Y. Strugar, A. A. Orlova, A. A. Ponkratova, A. K. Whaley, M. N. Povydysh

“…Isolation of individual secondary metabolites from the aerial part of C. palustre and their subsequent structural elucidation by NMR experiments.Materials and methods. …”
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Phylogenomics analysis of velvet regulators in the fungal kingdom by Wanping Chen, Ye-Eun Son, He-Jin Cho, Dasol Choi, Hee-Soo Park, Jae-Hyuk Yu

“…Altogether, this study improves our understanding of velvet regulators in the fungal kingdom.IMPORTANCEFungi are the relatives of animals in Opisthokonta and closely associated with human life by interactive ways such as pathogenicity, food, and secondary metabolites including beneficial ones like penicillin and harmful ones like the carcinogenic aflatoxins. …”
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Systematic Analysis and Expression Profiles of the 4-Coumarate: CoA Ligase (4CL) Gene Family in Pomegranate (<i>Punica granatum</i> L.) by Yuying Wang, Linhui Guo, Yujie Zhao, Xueqing Zhao, Zhaohe Yuan

“…<i>4-Coumarate:CoA ligase</i> (<i>4CL</i>, EC6.2.1.12), located at the end of the phenylpropanoid metabolic pathway, regulates the metabolic direction of phenylpropanoid derivatives and plays a pivotal role in the biosynthesis of flavonoids, lignin, and other secondary metabolites. In order to understand the molecular characteristics and potential biological functions of the <i>4CL</i> gene family in the pomegranate, a bioinformatics analysis was carried out on the identified <i>4CLs</i>. …”
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Transcriptome profiling of faba bean (Vicia faba L.) drought-tolerant variety hassawi-2 under drought stress using RNA sequencing by Muhammad Altaf Khan, Salem S. Alghamdi, Megahed H. Ammar, Qiwei Sun, Fei Teng, Hussein M. Migdadi, Sulieman A. Al-Faifi

“…According to the GO and KEGG databases, both the vegetative and flowering stages regulated energy metabolism, transmembrane transporter activity, and secondary metabolites. A total of 538 (272 upregulated and 266 downregulated) and 642 (300 upregulated and 342 downregulated) putative transcription factors in the vegetative and flowering stages, respectively, were identified and classified under different transcription factor families. …”
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Transcriptome profiling shows gene regulation patterns in a flavonoid pathway in response to exogenous phenylalanine in Boesenbergia rotunda cell culture by Md-Mustafa, N.D., Khalid, N., Gao, H., Peng, Z., Alimin, M.F., Bujang, N., Ming, W.S., Mohd-Yusuf, Y., Harikrishna, J.A., Othman, R.Y.

“…Reports on the health benefits of secondary metabolites extracted from Boesenbergia rotunda over the last few years has resulted in rising demands for panduratin A. …”

Metabolite profiling and defense gene expression of susceptible and tolerant oil palm seedling progenies at early stage of Ganoderma boninense infection by Syd Ali, Nusaibah

“…Thus the objectives of this study include i) to establish and confirm G.boninense infection on oil palm root seedlings using artificial inoculation method, ii) to identify secondary metabolites accumulated in oil palm roots at early stages of G.boninense infection and assess their antifungal activities and iii) to profile expression of key genes for the biosynthesis of the identified compounds involved in defense mechanism. …”
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Functional expression of plant sesquitepene synthases for isoprenoid production in lactococcus lactis by Song, Adelene Ai Lian

“…Plants produce a large variety of isoprenoids as secondary metabolites through the mevalonate (MVA) pathway and the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. …”
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Isolation of transketolase gene, subcellular localization, and transketolase protein structure studies of sugarcane (Saccharum officinarum. L) by Kalhori, Nahid

“…Erythrose-4- phosphate then enters the shikimate pathway that produced many secondary metabolites such as aromatic amino acids, lignin and flavonoid. …”
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Postharvest qualities and metabolic responses of hydro- cooled rockmelon (Cucumis melo L. reticulatus cv Glamour) after differential storage durations by Zainal, Bokhary

“…The high intensity of phenylalanine, tryptophan and tyrosine appear to be associated with biosynthesis of secondary metabolites and cold tolerance since their present were altered in 1/2 CT rockmelon, relative to the control and 3/4 CT hydro-cooled rockmelon. …”
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Composition and biological activities of seaweed in coastal waters of Bintulu, Sarawak, Malaysia by Zawawi, Mohd Hafizbillah

“…Seaweed communities are considered as important component in the coastal ecosystems and able to produce a great variety of secondary metabolites for biological activities. The coastline of Bintulu geographically surrounded by rocky shore areas and some reef areas provide favorable natural habitat for seaweed communities. …”
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Cytotoxicity and mode of action of Barrientosiimonas humi extract against breast cancer cell lines by Yeoh, Chiann Ying

“…Secondary metabolites from novel extremophilic actinobacteria are found to be potent sources of diverse novel anti-cancer compounds. …”
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Synergistic Response Of Pogostemon Cablin (Blanco) Benth. Cell Suspension Cultures To Precursor Feeding And Elicitation Towards The Production Of Patchoulol by Mazlan, Fatin Izzatie

“…Secondary metabolites in Pogostemon cablin (Blanco) Benth, especially patchoulolis known to possess strong neuroprotective activities, abilities for cognition enhancement as well as learning impairment attenuation. …”
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Graphene-magnetite as magnetic solid phase adsorbent for extraction of 4-hydroxybenzoic acid and 3,4-dihydroxybenzoic acid in stingless bee honey by Musa, Marina

“…Stingless bee honeys are rich in secondary metabolites such as free phenolic acids which can be easily absorbed into the body. …”
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GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) C.D. Adams leaves:... by Oluwafemi Adeleke Ojo, Akingbolabo Daniel Ogunlakin, Gideon Ampoma Gyebi, Damilare IyinKristi Ayokunle, Adeshina Isaiah Odugbemi, Dare Ezekiel Babatunde, Omolola Adenike Ajayi-Odoko, Matthew Iyobhebhe, Samson Chukwuemeka Ezea, Christopher Oloruntoba Akintayo, Ademola Ayeleso, Ademola Ayeleso, Adebola Busola Ojo, Omolara Olajumoke Ojo

“…Conclusively, the antioxidant, antidiabetic, and anti-inflammatory activities of EFSFL could be due to the presence of secondary metabolites.…”
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Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of <i>Vitex</i> sp. by Nurkhalida Kamal, Nurul Syahidah Mio Asni, Ivana Nur Allisya Rozlan, Muhammad Aniq Hamzah Mohd Azmi, Noor Wini Mazlan, Ahmed Mediani, Syarul Nataqain Baharum, Jalifah Latip, Suvik Assaw, Ru Angelie Edrada-Ebel

“…This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from <i>Vitex</i> sp., including the chemical compounds, biological activities, application of <i>Vitex</i> in human clinical trials, toxicology and safety, marketed products, and patents. …”
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Bacterial Long-Range Warfare: Aerial Killing of Legionella pneumophila by Pseudomonas fluorescens by Marie-Hélène Corre, Anne Mercier, Mathilde Bouteiller, Alix Khalil, Christophe Ginevra, Ségolène Depayras, Charly Dupont, Meg Rouxel, Mathias Gallique, Laettitia Grac, Sophie Jarraud, David Giron, Annabelle Merieau, Jean-Marc Berjeaud, Julien Verdon

“…With the aim of finding natural ways to control waterborne pathogens and thus further reduce the impact of disinfection by-products on human health, some studies have demonstrated the ability of bacteria to kill Legionella through the production of secondary metabolites or antimicrobial compounds. Here, we describe an unexpected growth inhibition of L. pneumophila when exposed to a physically separated strain of Pseudomonas fluorescens, designated as MFE01. …”
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Comprehensive Biological Potential, Phytochemical Profiling Using GC-MS and LC-ESI-MS, and In-Silico Assessment of <i>Strobilanthes glutinosus</i> Nees: An Important Medicinal Plan... by Marya Aziz, Saeed Ahmad, Umair Khurshid, Irfan Pervaiz, Arslan Hussain Lodhi, Nasrullah Jan, Sameera Khurshid, Muhammad Adeel Arshad, Mohamed M. Ibrahim, Gaber A. M. Mersal, Fahaad S. Alenazi, Ahmed Awadh Saleh Alamri, Juwairiya Butt, Hammad Saleem, Zeinhom M. El-Bahy

“…The GC-MS profiling of <i>n</i>-butanol and chloroform fractions revealed the existence of several (110) important compounds presenting different classes (fatty acids, phenols, alkanes, monoterpenes, diterpenes, sesquiterpenoids, and sterols), while LC-ESI-MS tentatively identified the presence of 44 clinically important secondary metabolites. The <i>n</i>-hexane fraction exhibited the highest potential against α-amylase (497.98 mm ACAE/g extract) and α-glucosidase (605.85 mm ACAE/g extract). …”
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Comparative Transcriptomics and Metabolites Analysis of Two Closely Related Euphorbia Species Reveal Environmental Adaptation Mechanism and Active Ingredients Difference by Han Zheng, Mu-Yao Yu, Yang Han, Badalahu Tai, Badalahu Tai, Sheng-Fa Ni, Rui-Feng Ji, Chun-Juan Pu, Kang Chen, Fu-Quan Li, Hua Xiao, Ye Shen, Xiu-Teng Zhou, Lu-Qi Huang

“…Additionally, 5 primary or secondary metabolites were screened as the biomarkers to distinguish the two species. …”
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Acute aflatoxin B1-induced hepatic and cardiac oxidative damage in rats: Ameliorative effects of morin by Ahmed E. Altyar, Osama A. Kensara, Amany A. Sayed, Lotfi Aleya, Mikhlid H. Almutairi, Mohamed Sayed Zaazouee, Alaa Ahmed Elshanbary, Fatma M. El-Demerdash, Mohamed M. Abdel-Daim

“…Aflatoxins (AFs) are secondary metabolites produced by the fungus Aspergillus flavus, of which Aflatoxin-B1 (AFB1) appears to be the most cancerogenic and of the highest toxicity. …”
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Metabolomics and Transcriptomics Reveal the Response Mechanisms of <i>Mikania micrantha</i> to <i>Puccinia spegazzinii</i> Infection by Xinghai Ren, Guangzhong Zhang, Mengjiao Jin, Fanghao Wan, Michael D. Day, Wanqiang Qian, Bo Liu

“…The levels of 74 metabolites, including organic acids, amino acids, and secondary metabolites in <i>M. micrantha</i> infected with <i>P. spegazzinii</i>, were significantly different compared to those in plants that were not infected. …”
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