Microcystin Concentrations and Detection of the <i>mcyA</i> Gene in Water Collected from Agricultural, Urban, and Recreational Areas in a Karst Aquifer in the Yucatan Peninsula of... by Gerardo Ávila-Torres, Gabriela Rosiles-González, Victor Hugo Carrillo-Jovel, Gilberto Acosta-González, Eduardo Cejudo-Espinosa, Daniela Ortega-Camacho, Cecilia Hernández-Zepeda, Oscar Alberto Moreno Valenzuela

“…The eutrophication of freshwater ecosystems allows the proliferation of cyanobacteria that can produce secondary metabolites such as microcystins. The main aim of this study was to explore the occurrence and concentration of microcystin and the <i>mcyA</i> gene in water bodies located in agricultural, urban, and recreational areas in the karst aquifer of the Yucatan peninsula of Mexico (YPM) and to analyze the water quality variables and chlorophyll-<i>a</i> (Chl-<i>a</i>) associated with their presence. …”
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The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy by Rasha Saad Suliman, Sahar Saleh Alghamdi, Rizwan Ali, Dimah Aljatli, Norah Abdulaziz Aljammaz, Sarah Huwaizi, Rania Suliman, Khawla Mohammed Kahtani, Ghadeer M. Albadrani, Tlili Barhoumi, Abdulelah Altolayyan, Ishrat Rahman

“…Results: Nine secondary metabolites were identified, and computational predictions suggested a good absorption profile, anticancer, anti-inflammatory, and wound-healing effects. …”
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Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake by Achille Parfait Atchan Nwakiban, Stefania Cicolari, Stefano Piazza, Fabrizio Gelmini, Enrico Sangiovanni, Giulia Martinelli, Lorenzo Bossi, Eugénie Carpentier-Maguire, Armelle Deutou Tchamgoue, Gabriel A. Agbor, Jules-Roger Kuiaté, Giangiacomo Beretta, Mario Dell’Agli, Paolo Magni

“…The ROS-scavenging ability of the spice extracts may reside in some secondary metabolites observed by phytochemical profiling (reverse-phase high-performance liquid chromatography coupled to a diode array detector (HPLC-UV-DAD)). …”
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Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in... by Yingying Wang, Siyi Zhang, Yuandan Ma, Xianmin Du, Qi Zong, Die Lin, Meng Lai, Tianyu Huang, Qingyun Luo, Lin Yang, Zhanyong Li, Zhaojiang Zuo

“…Abstract Plant secondary metabolites can protect organisms against oxidative stress caused by adverse environmental conditions. …”
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Establishment of a Rapid Micropropagation System for <i>Kaempferia parviflora</i> Wall. Ex Baker: Phytochemical Analysis of Leaf Extracts and Evaluation of Biological Activities by Han-Yong Park, Kyung-Su Kim, Gunes Ak, Gokhan Zengin, Zoltán Cziáky, József Jekő, Kathalingam Adaikalam, Kihwan Song, Doo-Hwan Kim, Iyyakkannu Sivanesan

“…This study aimed to establish a rapid in vitro plant regeneration method from rhizome buds of <i>Kaempferia parviflora</i> to obtain the valuable secondary metabolites with antioxidant and enzyme inhibition properties. …”
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Renewable Raw Materials : New Feedstocks for the Chemical Industry / by Ulber, Roland, editor 343045, Sell, Dieter, editor 388464, Hirth, Thomas, editor 522553

Natural Bio-active Compounds. Chemistry, Pharmacology and Health Care Practices / by Swamy, Mallappa Kumara, editor, Akhtar, Mohd. Sayeed, editor

Molecular Characterization of an <i>Isoflavone 2′-Hydroxylase</i> Gene Revealed Positive Insights into Flavonoid Accumulation and Abiotic Stress Tolerance in Safflower by Jianyu Liu, Naveed Ahmad, Yingqi Hong, Meihua Zhu, Shah Zaman, Nan Wang, Na Yao, Xiuming Liu

“…The diverse expression pattern of <i>CtCYP81E</i> genes in four different flowering stages suggested important clues into the regulation of secondary metabolites. Similarly, the variable expression of <i>CtCYP81E8</i> during multiple flowering stages further highlighted a strong relationship with metabolite accumulation. …”
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Dietary mycotoxin exposure and human health risks: A protocol for a systematic review by T. Goessens, T. Mouchtaris-Michailidis, K. Tesfamariam, N.N. Truong, F. Vertriest, Y. Bader, S. De Saeger, C. Lachat, M. De Boevre

“…Background: Mycotoxins are toxic fungal secondary metabolites that contaminate a wide spectrum of essential foods worldwide, such as grain-based products, nuts and spices, causing adverse health effects pertaining to their carcinogenic, nephrotoxic and hepatotoxic nature, among others. …”
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Integrative metabolomic and transcriptomic reveals potential mechanism for promotion of ginsenoside synthesis in Panax ginseng leaves under different light intensities by Ping Di, Xiao Yang, Mingming Wan, Mei Han, Yonggang Zhang, Limin Yang

“…This study elucidates molecular mechanisms underlying the photosynthetic physiology and ginsenoside synthesis in P. ginseng under varying light intensities and provides a theoretical basis for the P. ginseng cultivation and its industrial production of secondary metabolites.…”
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Early-Life Exposure to the Mycotoxin Fumonisin B1 and Developmental Programming of the Ovary of the Offspring: The Possible Role of Autophagy in Fertility Recovery by Awadh Alhelaisi, Abdulkarem Alrezaki, Saber Nahdi, Waleed Aldahmash, Saleh Alwasel, Abdel Halim Harrath

“…Mycotoxins are produced by more than one hundred fungi and produce secondary metabolites that contaminate various agricultural commodities, especially rice and corn. …”
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Effect of Feed Supplement Containing Dried Kratom Leaves on Apparent Digestibility, Rumen Fermentation, Serum Antioxidants, Hematology, and Nitrogen Balance in Goats by Pin Chanjula, Juraithip Wungsintaweekul, Rawee Chiarawipa, Adirek Rugkong, Benjamad Khonkhaeng, Chanon Suntara, Anusorn Cherdthong

“…The DKTL was high in secondary metabolites, including mitragynine, total phenolics, total tannins, flavonoids, and saponins. …”
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Integration of transcriptome and metabolome analyses reveals key lodging-resistance-related genes and metabolic pathways in maize by Lei Liu, Songtao Liu, Haibo Lu, Zaimin Tian, Haichao Zhao, Dong Wei, Shuo Wang, Zhihong Huang

“…Additionally, key lodging resistance–related metabolic pathways were obtained by KEGG enrichment analysis, and the DEGs were found predominantly enriched in phenylpropanoid and secondary metabolites biosynthesis pathways in the L_vs._H and M_vs.…”
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HR-LC-ESI-Orbitrap-MS-Based Metabolic Profiling Coupled with Chemometrics for the Discrimination of Different <i>Echinops spinosus</i> Organs and Evaluation of Their Antioxidant Ac... by Amel Bouzabata, Paola Montoro, Katarzyna Angelika Gil, Sonia Piacente, Fadia S. Youssef, Nawal M. Al Musayeib, Geoffrey A. Cordell, Mohamed L. Ashour, Carlo Ignazio Giovanni Tuberoso

“…The score plot discriminates different <i>Echinopsis spinosus</i> organs into three distinct clusters, with the stems and flowers allocated in the same cluster, reflecting their resemblance in their secondary metabolites. The antioxidant activities of the methanol extracts were assessed using cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant assay (FRAP), diphenyl picryl hydrazyl radical-scavenging capacity assay (DPPH<b>^●</b>), and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS<b>^●</b>⁺). …”
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Rare Glutamic Acid Methyl Ester Peptaibols from <i>Sepedonium ampullosporum</i> Damon KSH 534 Exhibit Promising Antifungal and Anticancer Activity by Yen T. H. Lam, Manuel G. Ricardo, Robert Rennert, Andrej Frolov, Andrea Porzel, Wolfgang Brandt, Pauline Stark, Bernhard Westermann, Norbert Arnold

“…Fungal species of genus <i>Sepedonium</i> are rich sources of diverse secondary metabolites (e.g., alkaloids, peptaibols), which exhibit variable biological activities. …”
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Identification of bioactive compounds of Bacillus velezensis HNA3 that contribute to its dual effects as plant growth promoter and biocontrol against post-harvested fungi by Doaa S. Zaid, Wenya Li, Siyu Yang, Youguo Li

“…IMPORTANCE The current study is an extension to our previous work on the plant growth-promoting rhizobacteria (PGPR) Bacillus velezensis HNA3 strain, which comes to confirm and reveals the huge stock of active secondary metabolites produced by HNA3. HNA3-emitted volatile organic compounds (VOCs) have demonstrated the capacity to impede the growth of phytopathogens affecting some fruits and vegetables, even in the absence of direct contact. …”
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N-Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus by Yu Wang, Ranxun Lin, Mengxin Liu, Sen Wang, Hongyu Chen, Wanlin Zeng, Xinyi Nie, Shihua Wang

“…ABSTRACT The filamentous fungus Aspergillus flavus causes devastating diseases not only to cash crops but also to humans by secreting a series of secondary metabolites called aflatoxins. In the cotranslational or posttranslational process, N-myristoyltransferase (Nmt) is a crucial enzyme that catalyzes the myristate group from myristoyl-coenzyme A (myristoyl-CoA) to the N terminus or internal glycine residue of a protein by forming a covalent bond. …”
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The Solvent Dimethyl Sulfoxide Affects Physiology, Transcriptome and Secondary Metabolism of <i>Aspergillus flavus</i> by Laura H. Costes, Yannick Lippi, Claire Naylies, Emilien L. Jamin, Clémence Genthon, Sylviane Bailly, Isabelle P. Oswald, Jean-Denis Bailly, Olivier Puel

“…A total of 4650 genes were specifically regulated in response to the highest dose of DMSO, while only 19 genes were modulated upon exposure to the lowest dose. Secondary metabolites clusters genes were widely affected by the DMSO, with 91% of clusters impacted at the highest dose. …”
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Chemical Composition and Antioxidant Activity of Thyme, Hemp and Coriander Extracts: A Comparison Study of Maceration, Soxhlet, UAE and RSLDE Techniques by Sara Palmieri, Marika Pellegrini, Antonella Ricci, Dario Compagnone, Claudio Lo Sterzo

“…Appropriate and standardized techniques for the extraction of secondary metabolites with interesting biological activity from plants are required. …”
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UHPLC-MS/MS phytochemical screening, polyphenolic content and antioxidant potential of Diplorhynchus condylocarpon (Müll.Arg.) Pichon (Apocynaceae), a medicinal plant by Chibuye Bitwell, Singh Indra Sen, Chimuka Luke, Maseka Kenneth Kakoma

“…Maceration was used to extract secondary metabolites for preliminary phytochemical screening. …”
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