Climate Change and Its Impact on Crops: A Comprehensive Investigation for Sustainable Agriculture by Aradhna Kumari, Geetha Ajay Lakshmi, Gopinathan Kumar Krishna, Babita Patni, Soban Prakash, Malini Bhattacharyya, Santosh Kumar Singh, Krishan Kumar Verma

“…The production of antioxidants and secondary metabolites may keep a check on the content of oxidating molecules. …”
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De novo sequencing, assembly, and characterization of Asparagus racemosus transcriptome and analysis of expression profile of genes involved in the flavonoid biosynthesis pathway by Chanchal Malik, Sudhanshu Dwivedi, Tilahun Rabuma, Tilahun Rabuma, Ravinder Kumar, Nitesh Singh, Anil Kumar, Rajesh Yogi, Vinod Chhokar

“…Asparagus racemosus is known for its diverse content of secondary metabolites, i.e., saponins, alkaloids, and a wide range of flavonoids. …”
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Insights into the Cytochrome P450 Monooxygenase Superfamily in <i>Osmanthus fragrans</i> and the Role of <i>OfCYP142</i> in Linalool Synthesis by Jiawei Liu, Hongmin Hu, Huimin Shen, Qingyin Tian, Wenjie Ding, Xiulian Yang, Lianggui Wang, Yuanzheng Yue

“…<i>fragrans</i> petals, we found that the biosynthesis pathway of secondary metabolites was significantly enriched, and many 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes were also upregulated. …”
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Knockout of <i>Pi21</i> by CRISPR/Cas9 and iTRAQ-Based Proteomic Analysis of Mutants Revealed New Insights into <i>M. oryzae</i> Resistance in Elite Rice Line by Gul Nawaz, Babar Usman, Haowen Peng, Neng Zhao, Ruizhi Yuan, Yaoguang Liu, Rongbai Li

“…The most of DEPs were involved in metabolic, ribosomal, secondary metabolites biosynthesis, and carbon metabolism pathways. 40S ribosomal protein S15 (P31674), 50S ribosomal protein L4, L5, L6 (Q10NM5, Q9ZST0, Q10L93), 30S ribosomal protein S5, S9 (Q6YU81, Q850W6, Q9XJ28), and succinate dehydrogenase (Q9S827) were hub-proteins. …”
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Determination of Antioxidant Activity and Sun Protection Factor of Commercial Essential Oils by Filomena Monica Vella, Domenico Cautela, Bruna Laratta

“…Among all, essential oils (EOs) are an important group of secondary metabolites that, even if not essential for plant survival, are significant for their allelopathic effects, either negative or positive, on microbes and the environment. …”
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Mycotoxins at the Start of the Food Chain in Costa Rica: Analysis of Six <i>Fusarium</i> Toxins and Ochratoxin A between 2013 and 2017 in Animal Feed and Aflatoxin M₁ in... by Andrea Molina, Guadalupe Chavarría, Margarita Alfaro-Cascante, Astrid Leiva, Fabio Granados-Chinchilla

“…Mycotoxins are secondary metabolites, produced by fungi of genera <i>Aspergillus</i>, <i>Penicillium</i> and <i>Fusarium</i> (among others), which produce adverse health effects on humans and animals (carcinogenic, teratogenic and immunosuppressive). …”
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Single and cumulative effects of whole-vine heat events on Shiraz berry composition by Julia Claire Gouot, Jason Smith, Bruno Holzapfel, Celia Barril

“…Berries were sampled from fruit set until maturity at regular intervals, and primary and secondary metabolites, including detailed tannin composition, were analysed by GC-MS and LC-MS/MS, respectively. …”
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Integrative Omics Analysis of Three Oil Palm Varieties Reveals (Tanzania × Ekona) TE as a Cold-Resistant Variety in Response to Low-Temperature Stress by Mumtaz Ali Saand, Jing Li, Yi Wu, Lixia Zhou, Hongxing Cao, Yaodong Yang

“…The KEGG pathway correlation of oil palm has shown that the metabolic synthesis and biosynthesis of secondary metabolites pathways were significantly enriched in the transcriptome and proteome of the oil palm varieties. …”
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Evaluation of Antimicrobial and Anticancer Activities of Selected Medicinal Plants of Himalayas, Pakistan by Farzana Kausar, Kyung-Hwan Kim, Hafiz Muhammad Umer Farooqi, Muhammad Awais Farooqi, Muhammad Kaleem, Rooma Waqar, Atif Ali Khan Khalil, Fazli Khuda, Chethikkattuveli Salih Abdul Rahim, Kinam Hyun, Kyung-Hyun Choi, Abdul Samad Mumtaz

“…The preliminary phytochemical screening showed the presence of secondary metabolites such as alkaloids, tannins, saponins, flavonoids, glycosides, and quinones. …”
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Jusanin, a New Flavonoid from <i>Artemisia commutata</i> with an In Silico Inhibitory Potential against the SARS-CoV-2 Main Protease by Yerlan M. Suleimen, Rani A. Jose, Raigul N. Suleimen, Christoph Arenz, Margarita Y. Ishmuratova, Suzanne Toppet, Wim Dehaen, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa, Ahmed M. Metwaly

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Genome-wide profiling of histone (H3) lysine 4 (K4) tri-methylation (me3) under drought, heat, and combined stresses in switchgrass by Vasudevan Ayyappan, Venkateswara R. Sripathi, Shaojun Xie, Malay C. Saha, Rita Hayford, Desalegn D. Serba, Mayavan Subramani, Jyothi Thimmapuram, Antonette Todd, Venu Kal Kalavacharla

“…Further, we identified significant peaks associated with TFs, hormones, signaling, fatty acid and carbohydrate metabolism, and secondary metabolites. qRT-PCR analysis revealed the relative expressions of six abiotic stress-responsive genes (transketolase, chromatin remodeling factor-CDH3, fatty-acid desaturase A, transmembrane protein 14C, beta-amylase 1, and integrase-type DNA binding protein genes) that were significantly (P < 0.05) marked during drought, heat, and combined stresses by comparing stress-induced against un-stressed and input controls. …”
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Exploring Iron Withholding by the Innate Immune Protein Human Calprotectin by Zygiel, Emily Mikayla, Nolan, Elizabeth Marie

“…We also elucidated a complex interplay between CP and secondary metabolites produced by P. aeruginosa during the competition for Fe. …”
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Discovery and functional characterization of cysteine-rich peptides from medicinal plants by Loo, Shining

“…An overwhelming majority of research effort has focused on small molecules, the primary and secondary metabolites with MW <1 kDa. With the advances in molecular biology, plant proteins with MW >10 kDa have also been extensively studied in life and agriculture sciences. …”
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Phytochemical study of dryobalanops from Malaysian dipterocarpaceae and structure-activity relationship studies / Agustono Wibowo by Wibowo, Agustono

“…The aims of this study are to isolate secondary metabolites, to determine their antibacterial, DPPH scavenging and cytotoxic activities, to study structureactivity relationship, and to propose biogenesis pathway and chemotaxonomic significance in Dryobalanops. …”
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Biovanillin production from lemongrass leaves hydrolysates by Phanerochaete chrysosporium ATCC 24725 in batch culture by Galadima, Ahmed Ibrahim

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Glycogen synthase kinase-3β (GSK-3β) inhibitors from soil actinomycetes of Sabah rainforests : screening, purification and identification by Fauze Mahmud

“…External factors such as nutrient availability and pH may influence the production of secondary metabolites by actinomycetes. GSK-3β inhibitors were previously identified in Streptomyces sp. isolated from primary rainforests of Sabah. …”
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Optimisation of Cell Cultures and Cytotoxic Activity of Pereskia Bleo (kunth) dc. Extracts by Sulong, Noor Anilizawatima

“…Elicitation of secondary metabolites was also attempted using pectin and jasmonic acid. …”
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Genetic diversity, growth effecting factors and nutritional value of moringa by Rufa'i, Shamsuddeen

“…Folin-Ciocalteu‟s and aluminium chloride calorimetric assay revealed high levels of secondary metabolites (ranging from 1000 – 1350 mg gallic acid equivalent (GAE)/100 g DW total phenolics and up to 2400 mg quercetin equivalent (QE)/1 mg DW total flavonoids), and the wet digestion procedure revealed the presence of 9 mineral nutrient elements (with significant values of up to 19.13 g kg-1 maximum)content acquired from calcium (Ca) and up to 9.90 g kg-1 recorded for iron (Fe).These nutritive components are noted to be highest (312.5% higher in terms of antioxidants) in the leaves portion, followed by the roots, and then the stem parts. …”
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Isolation, molecular and biomedical characterisation of endophytes from selected medicinal plants by Chin, Elaine Jinfeng

“…They have been found to produce secondary metabolites which are significant sources of novel compounds that have the potential for pharmaceutical, agricultural and biotechnological applications. …”
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Medium optimization for high cell mass and exopolysaccharides production using paenibacillus polymyxa by Daud, Nur Sazwani

“…Paenibacillus polymyxa ATCC 842 is one of the beneficial microbes that shows high potential to promote plant growth and enhance soil health by producing a variety of beneficial secondary metabolites specifically exopolysaccharides (EPS). …”
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