Enhancement of carbamazepine removal rate using Tetradesmus obliquus KNUA061 and NaOCl and utilization of the resulting biomass by Jeong-Mi Do, Jeong-Mi Do, Jeong-Mi Do, Hee-Tae Yeo, Hee-Tae Yeo, Geum-Sook Do, Ji Won Hong, Ji Won Hong, Ho-Sung Yoon, Ho-Sung Yoon, Ho-Sung Yoon, Ho-Sung Yoon

“…Roughly 90% of CBZ remained its original form and the composition of the transformed secondary metabolites was less than 10% during the biodegradation process by the microalga. …”
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Comparative Transcriptome Investigation of <i>Nosema ceranae</i> Infecting Eastern Honey Bee Workers by Yuanchan Fan, Jie Wang, Kejun Yu, Wende Zhang, Zongbing Cai, Minghui Sun, Ying Hu, Xiao Zhao, Cuiling Xiong, Qingsheng Niu, Dafu Chen, Rui Guo

“…Additionally, KEGG pathway analysis suggested that the DEGs were engaged in an array of pathways of great importance such as metabolic pathway, glycolysis, and the biosynthesis of secondary metabolites. Furthermore, expression clustering analysis demonstrated that the majority of genes encoding virulence factors such as ricin B lectins and polar tube proteins displayed apparent upregulation, whereas a few virulence factor-associated genes such as hexokinase gene and 6-phosphofructokinase gene presented downregulation during the fungal infection. …”
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Microbiomics and volatile metabolomics-based investigation of changes in quality and flavor of oat (Avena sativa L.) silage at different stages by Xiaochen Deng, Yushan Jia, Gentu Ge, Gentu Ge, Zhijun Wang, Zhijun Wang, Mingjian Liu, Mingjian Liu, Jian Bao, Jian Bao, Muqier Zhao, Muqier Zhao, Qiang Si, Qiang Si, Yichao Liu, Yichao Liu, Weixuan Zhao, Weixuan Zhao

“…The results of Kyoto encyclopedia of genes and genomes pathway enrichment analysis demonstrated three major metabolic pathways: phenylpropanoid biosynthesis, phenylalanine metabolism, and biosynthesis of secondary metabolites. Specific microorganisms were significantly correlated with flavor indicators and flavor metabolites. …”
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Effects of <i>Artemisia macrocephala</i> Jacquem on Memory Deficits and Brain Oxidative Stress in Streptozotocin-Induced Diabetic Mice by Atiqul Bari, Syed Muhammad Mukarram Shah, Fakhria A. Al-Joufi, Syed Wadood Ali Shah, Mohammad Shoaib, Ismail Shah, Muhammad Zahoor, Muhammad Naeem Ahmed, Mehreen Ghias, Syed Muhammad Hassan Shah, Atif Ali Khan Khalil

“…Further studies are needed to explore the beneficial role of the secondary metabolites isolated in the present study as memory enhancers. …”
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Integrated transcriptomic and metabolic analyses provide insights into the maintenance of embryogenic potential and the biosynthesis of phenolic acids and flavonoids involving tran... by Junchen Wang, Junchen Wang, Lifeng Zhang, Lifeng Zhang, Liwang Qi, Liwang Qi, Shougong Zhang, Shougong Zhang

“…Both EC and NEC had vigorous primary metabolic activities, while most secondary metabolites were upregulated in NEC. Many totipotency-related transcription factor (TF) genes such as BBMs, WUSs, and LEC1 showed higher expression levels in EC compared with NEC, which may result in the higher accumulation of indole 3-acetic acid (IAA) in EC. …”
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Phytochemical Investigation and Biological Studies on Selected <i>Searsia</i> Species by Mkhuseli Koki, Masande Yalo, Masixole Makhaba, Ndikho Nako, Fanie Rautenbach, Jelili A. Badmus, Jeanine Marnewick, Ahmed A. Hussein, Wilfred T. Mabusela

“…In this study, the extraction, isolation, and identification of secondary metabolites from three <i>Searsia</i> species (<i>Searsia glauca, S. lucida</i>, and <i>S. laevigata</i>) were conducted using chromatographic and spectroscopic techniques and afforded five known terpenes, viz., moronic acid (<b>1</b>), 21β-hydroxylolean-12-en-3-one (<b>2</b>), lupeol (<b>11</b>), α-amyrin (<b>9</b>), and β-amyrin (<b>10</b>), in addition to six known flavonoids, myricetin-3-<i>O-</i>β-galactopyranoside (<b>3</b>), rutin (<b>4</b>), quercetin (<b>5</b>), apigenin (<b>6</b>), amentoflavone (<b>7</b>), and quercetin-3-<i>O-</i>β-glucoside (<b>8</b>). …”
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Mechanism of the Change in the Intestinal Microbiota of C-Strain <i>Spodoptera frugiperda</i> (Lepidoptera: Noctuidae) after an Interspecific Transference between Rice and Corn by Teng Di, Yongping Li, Guangzu Du, Yanyan He, Wenqian Wang, Yunfeng Shen, Jizhi Meng, Wenxiang Xiao, Guanli Xiao, Bin Chen

“…The results showed that after feeding on rice, the activities of CAT and POD in the in <i>S. frugiperda</i> body changed in order to resist plant secondary metabolites from corn or rice, but there was no significant change in the detoxification enzymes in the body. …”
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Phytochemical screening, biological evaluation, and molecular docking studies of aerial parts of Trigonella hamosa (branched Fenugreek) by Huma Rao, Saeed Ahmad, Hanan Y.Aati, Abdul Basit, Imtiaz Ahmad, Bilal Ahmad Ghalloo, Muhammad Nadeem Shehzad, Rahat Nazar, Muhammad Zeeshan, Muhammad Jawad Nasim, Kashif ur Rehman Khan

“…The preliminary phytochemical screening revealed the presence of various primary and secondary metabolites in extract and fractions of T. hamosa, polyphenolic quantification of METH showed highest TPC (139.32 ± 2.07 mg GAE/g D.E.) and TFC (61.31 ± 3.12 mg QE/g D.E). …”
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Relationship between Total Antioxidant Capacity, Cannabinoids and Terpenoids in Hops and Cannabis by Philip Wiredu Addo, Zohreh Poudineh, Michelle Shearer, Nichole Taylor, Sarah MacPherson, Vijaya Raghavan, Valérie Orsat, Mark Lefsrud

“…The effects of postharvest pre-freezing and drying [microwave-assisted hot air (MAHD) and freeze drying] on hops and cannabis were evaluated to determine the relationship between antioxidant activity and secondary metabolites. The 2,2-diphenyl-1-picrylhydrazine (DPPH) reduction and ferric reducing ability of power (FRAP) assays were assessed for suitability in estimating the antioxidant activity of extracted hops and cannabis inflorescences and correlation with cannabinoid and terpene content. …”
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QTL and Candidate Genes for Seed Tocopherol Content in ‘Forrest’ by ‘Williams 82’ Recombinant Inbred Line (RIL) Population of Soybean by Dounya Knizia, Jiazheng Yuan, Naoufal Lakhssassi, Abdelhalim El Baze, Mallory Cullen, Tri Vuong, Hamid Mazouz, Henry T. Nguyen, My Abdelmajid Kassem, Khalid Meksem

“…Soybean seeds are rich in secondary metabolites which are beneficial for human health, including tocopherols. …”
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Toxicological Profile and Anti-Inflammatory Effect of Mucoadhesive Gel from Residues of <i>Agave sisalana</i> and <i>Punica granatum</i> by Júlia Amanda Rodrigues Fracasso, Ingrid Yuri Galindo Sikina, Luísa Taynara Silvério da Costa, Lucas Pires Guarnier, João Tadeu Ribeiro-Paes, Fernando Yutaka de Ferreira, Luan Victor Coelho de Almeida, Beatriz de Castro Silva, Débora de Barros Barbosa, Valdecir Farias Ximenes, Desirre Venkli, Amanda Martins Viel, Lucinéia dos Santos

“…In this direction, the plants <i>Agave sisalana</i> (sisal) and <i>Punica granatum</i> (pomegranate) are rich in saponins, which are secondary metabolites known for their therapeutic properties, including anti-inflammatory effects. …”
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High-Performance Thin-Layer Chromatography for Rutin, Chlorogenic Acid, Caffeic Acid, Ursolic Acid, and Stigmasterol Analysis in <i>Periploca aphylla</i> Extracts by Raha Orfali, Shagufta Perveen, Hanan Y. Aati, Perwez Alam, Omar M. Noman, Javier Palacios, Bayan Salem S. Al-Kurbi, Areej M. Al-Taweel, Afsar Khan, Rashad Mehmood, Shabana Iqrar Khan

“…In addition, five bioactive secondary metabolites were isolated from the aerial parts of the plant: rutin, chlorogenic acid, caffeic acid, ursolic acid, and stigmasterol. …”
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A Diverged Transcriptional Network for Usage of Two Fe-S Cluster Biogenesis Machineries in the Delta-Proteobacterium Myxococcus xanthus by Mathieu Sourice, Isabel Askenasy, Pierre Simon Garcia, Yann Denis, Gaël Brasseur, Patricia J. Kiley, Béatrice Py, Corinne Aubert

“…This new knowledge also paves the way to improve production of Fe-S-dependent secondary metabolites using M. xanthus as a chassis.…”
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Traditional Use, Phytochemical Profiles and Pharmacological Properties of <i>Artemisia</i> Genus from Central Asia by Aliya Nurlybekova, Aidana Kudaibergen, Aizhan Kazymbetova, Magzhan Amangeldi, Aizhamal Baiseitova, Meirambek Ospanov, Haji Akber Aisa, Yang Ye, Mohamed Ali Ibrahim, Janar Jenis

“…Furthermore, our aim is to search for promising and potentially active <i>Artemisia</i> species candidates, encouraging us to analyze Protein Tyrosine Phosphatase 1B (PTP1B), α-glucosidase and bacterial neuraminidase (BNA) inhibition as well as the antioxidant potentials of <i>Artemisia</i> plant extracts, in which endemic species have not been explored for their secondary metabolites and biological activities so far. The main result of the study was that, for the first time, the species <i>Artemisia scopiformis</i> Ledeb. …”
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Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives in Alkanna tinctoria Tausch. grown in semi-hydroponic and pot cultivation systems by Yanyan Zhao, Annalisa Cartabia, Mónica Garcés-Ruiz, Marie-France Herent, Joëlle Quetin-Leclercq, Sergio Ortiz, Sergio Ortiz, Stéphane Declerck, Ismahen Lalaymia

“…It associates with arbuscular mycorrhizal fungi (AMF), which are known, amongst others beneficial effects, to modulate the plant secondary metabolites (SMs) biosynthesis. However, to the best of our knowledge, no study on the effects of AMF strains on the growth and production of A/Sd in A. tinctoria has been reported in the literature.MethodsHere, three experiments were conducted. …”
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Comparative Analysis of the Chemical Composition and Antimicrobial Activity of Four Moroccan North Middle Atlas Medicinal Plants’ Essential Oils: <i>Rosmarinus officinalis</i> L.,... by Aman Allah Gourich, Noureddine Bencheikh, Mohamed Bouhrim, Mohamed Regragui, Rachid Rhafouri, Aziz Drioiche, Ayoub Asbabou, Firdaous Remok, Aicha Mouradi, Mohamed Addi, Christophe Hano, Touriya Zair

“…Medicinal plants represent an inexhaustible source of traditional and effective remedies thanks to the various active ingredients they contain. Secondary metabolites present in plant extracts, such as essential oils (EO), have remarkable pharmacological properties, including antimicrobial effects. …”
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Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (<i>Drimys winteri</i> J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae)... by Ruth E. Barrientos, Javier Romero-Parra, Fredi Cifuentes, Javier Palacios, Néstor Jaime Romero-Jola, Adrián Paredes, Gabriel Vargas-Arana, Mario J. Simirgiotis

“…Our results confirm that <i>D. winteri</i> fruits are a rich source of secondary metabolites and can inhibit enzymes associated with neurodegenerative diseases; the results also suggest that canelo may induce a potentially hypotensive effect in rat aorta. …”
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Identification and Expression Analysis of the Ethylene Response Factor Gene Family in Tea Plant (<i>Camellia sinensis</i>) by Tao Zhang, Ju Cai, Sisi Wang, Litang Lv, Dandan Yuan, Xiaofang Zeng, Jianrong Li, Yan Li

“…The <i>ERF</i> gene family is widely present in plants and has crucial regulatory importance in plant seed development, organ morphogenesis, the synthesis of secondary metabolites, and coping with abiotic stresses such as cold and drought. …”
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Comparative Analysis of Clinical and Environmental Strains of Exophiala spinifera by Long-Reads Sequencing and RNAseq Reveal Adaptive Strategies by Yinggai Song, Yinggai Song, Yinggai Song, Minghao Du, Nickolas Menezes da Silva, Nickolas Menezes da Silva, Ence Yang, Vania A. Vicente, G. Sybren de Hoog, G. Sybren de Hoog, G. Sybren de Hoog, Ruoyu Li, Ruoyu Li, Ruoyu Li

“…Seventeen gene clusters were involved in the production of secondary metabolites. PKS-cluster 17 was consistently found to be absent in the clinical strain. …”
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Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival by Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E. Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman

“…Liquid chromatography-mass spectrometry (LC–MS) was performed to identify the secondary metabolites in the ethanol and ethyl acetate extracts, followed by in silico techniques to predict molecular targets and interactions, safety, and pharmacokinetic profile for identified metabolites. …”
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