Culturomics and Circular Agronomy: Two Sides of the Same Coin for the Design of a Tailored Biofertilizer for the Semi-Halophyte <i>Mesembryanthemum crystallinum</i> by Eloísa Pajuelo, Noris J. Flores-Duarte, Salvadora Navarro-Torre, Ignacio D. Rodríguez-Llorente, Enrique Mateos-Naranjo, Susana Redondo-Gómez, José A. Carrasco López

“…Additionally, the results of the plant metabolome revealed a differential accumulation of several primary and secondary metabolites with pharmaceutical properties. Overall, the results demonstrated the feasibility of using “low cost media” based on plant biomass to carry out a culturomics approach in order to isolate the most suitable bacteria for biofertilizers. …”
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Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by pathogenicity and comparative genomic... by J. Francis Borgio, Rahaf Alhujaily, Rahaf Alquwaie, Maryam Jawad Alabdullah, Eman AlHasani, Wojod Alothman, Rawan Khalid Alaqeel, Aqeelah Salman Alfaraj, Ayidah Kaabi, Norah F. Alhur, Sultan Akhtar, Reem AlJindan, Sarah Almofty, Noor B. Almandil, Sayed AbdulAzeez

“…Genome mining analysis revealed that MR14M3-coded secondary metabolites are involved in the biosynthesis of polyketides (PKs) and nonribosomal peptide synthases (NRPSs), including 11 biosynthesis-related gene clusters with one hundred percent similarity. …”
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Mechanistic insights into the hepatoprotective properties of Mallotus phillipensis fruit: Targeting proinflammatory cytokines and free radicals using isolated compound by Waseem Rizvi, Syed Shariq Naeem, Ompal Singh, Shagufta Moin, Kafil Akhtar, Syed Najmul Hejaz Azmi, Zubair Ahmed, Monowarul Mobin Siddique, Zainul Amiruddin Zakaria, Qamar Uddin Ahmed

“…Widely used in the Ayurvedic healthcare system, parts of the plant which are rich in secondary metabolites are used in the treatment of several diseases like eczema, bronchitis, worm infestation, diabetes, kidney stones, cancer, and malaria. …”
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Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, <i>Eunic... by Dario Matulja, Petra Grbčić, Krunoslav Bojanić, Natalija Topić-Popović, Rozelindra Čož-Rakovac, Sylvain Laclef, Tomislav Šmuc, Ozren Jović, Dean Marković, Sandra Kraljević Pavelić

“…Qualitative chemical evaluation revealed the presence of several classes of secondary metabolites extended with mass spectrometry analysis and tentative dereplication by using Global Natural Product Social Molecular Networking online platform (GNPS). …”
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Chemical Constituents of <i>Macaranga occidentalis</i>, Antimicrobial and Chemophenetic Studies by Viviane Flore Kamlo Kamso, Christophe Colombe Simo Fotso, Ines Michèle Kanko Mbekou, Billy Tchegnitegni Tousssie, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Norbert Sewald, Marcel Frese, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso

“…The aim of the present work was to evaluate the antimicrobial potential of the crude extract, fractions, and some isolated secondary metabolites from the leaves of <i>Macaranga occidentalis</i>, a Cameroonian medicinal plant traditionally used for the treatment of microbial infections. …”
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Phenolic Constituents from <i>Wendlandia tinctoria</i> var. <i>grandis</i> (Roxb.) DC. Stem Deciphering Pharmacological Potentials against Oxidation, Hyperglycemia, and Diarrhea: P... by Mamtaz Farzana, Md. Jamal Hossain, Ahmed M. El-Shehawi, Md. Al Amin Sikder, Mohammad Sharifur Rahman, Muhammad Abdullah Al-Mansur, Sarah Albogami, Mona M. Elseehy, Arpita Roy, M. Aftab Uddin, Mohammad A. Rashid

“…The present research intended to explore the pharmacological potential of the stem extract of <i>W. tinctoria</i>, focusing on the antioxidant, hypoglycemic, and antidiarrheal properties, and to isolate various secondary metabolites as mediators of such activities. A total of eight phenolic compounds were isolated from the dichloromethane soluble fraction of the stem extract of this plant, which were characterized by electrospray ionization (ESI) mass spectrometric and ¹H NMR spectroscopic data as liquiritigenin (<b>1</b>), naringenin (<b>2</b>), apigenin (<b>3</b>), kaempferol (<b>4</b>), glabridin (<b>5</b>), ferulic acid (<b>6</b>), 4-hydroxybenzoic acid (<b>7</b>), and 4-hydroxybenzaldehyde (<b>8</b>). …”
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Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of <i>Ajuga iva</i> (L.) by Soukaina Saidi, Firdaous Remok, Nadia Handaq, Aziz Drioiche, Aman Allah Gourich, Naoual El Menyiy, Smail Amalich, Mohamed Elouardi, Hanane Touijer, Mohamed Bouhrim, Latifa Bouissane, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia, Touriya Zair

“…The phytochemical screening carried out on the different extracts of <i>Ajuga iva</i> showed its richness in primary (lipids and proteins) and secondary metabolites (flavonoids, tannins, reducing compounds, oses, and holoside. …”
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Formulating co-loaded nanoliposomes with gallic acid and quercetin for enhanced cancer therapy by Ali Al-Samydai, Moath Al Qaraleh, Khaldun M. Al Azzam, Amal Mayyas, Hamdi Nsairat, Maha N. Abu Hajleh, Lidia K. Al-Halaseh, Nehaya Al-Karablieh, Amal Akour, Fatima Alshaik, Walhan Alshaer

“…Natural products have been used in oncology medicine either in crude form or by utilizing isolated secondary metabolites. Biologically active phytomolecules such as gallic acid and quercetin have confirmed antioxidant, anti-bacterial, and neoplastic properties. …”
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Magnesium Nutrient Application Induces Metabolomics and Physiological Responses in Mulberry (<i>Morus alba</i>) Plants by Xin Jin, Michael Ackah, Lei Wang, Frank Kwarteng Amoako, Yisu Shi, Lionnelle Gyllye Essoh, Jianbin Li, Qiaonan Zhang, Haonan Li, Weiguo Zhao

“…These classes of compounds were mainly involved in lipid metabolism, amino acid metabolism, energy metabolism, the biosynthesis of other secondary metabolites, the biosynthesis of other amino acids, the metabolism of cofactors and vitamin pathways, indicating that mulberry plants respond to Mg concentrations by producing a divergent metabolism. …”
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A method for mining condition-specific co-expressed genes in Camellia sinensis based on k-means clustering by Zheng, Xinghai, Lim, Peng Ken, Mutwil, Marek, Wang, Yuefei

“…Background: As one of the world’s most important beverage crops, tea plants (Camellia sinensis) are renowned for their unique flavors and numerous beneficial secondary metabolites, attracting researchers to investigate the formation of tea quality. …”
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Chemical constituents isolated from the ethyl acetate extract of the roots of garcinia atroviridis by Nur Salsabila, Ahmad Roslan

“…Several preliminary studies on the roots of Garcinia atroviridis have reported on their antibacterial and antioxidant properties, which might be contributed by various bioactive secondary metabolites. Chemical compounds in the roots of G. atroviridis were isolated from ethyl acetate extract as the solvent was reportedly efficient for extraction of phenolic compounds with intermediate polarity. …”
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Effects of Dietary Protein Levels on Sheep Gut Metabolite Profiles during the Lactating Stage by Sikandar Ali, Xiaojun Ni, Muhammad Khan, Xiaoqi Zhao, Hongyuan Yang, Baiji Danzeng, Imtiaz Hussain Raja, Guobo Quan

“…Diet-associated characteristics such as dietary protein levels can modulate the gut’s primary or secondary metabolites, leading to effects on the productive performance and overall health of animals. …”
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In Vitro and In Silico Investigation of Polyacetylenes from <i>Launaea capitata</i> (Spreng.) Dandy as Potential COX-2, 5-LOX, and BchE Inhibitors by Fatma M. Abdel Bar, Amira Mira, Ahmed I. Foudah, Manal A. Alossaimi, Shatha F. Alkanhal, Alanoud M. Aldaej, Mai H. ElNaggar

“…Diverse secondary metabolites are biosynthesized by plants via various enzymatic cascades. …”
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Identification of Antibacterial Sterols from Korean Wild Mushroom <i>Daedaleopsis confragosa</i> via Bioactivity- and LC-MS/MS Profile-Guided Fractionation by Myung Woo Na, Eunjin Lee, Dong-Min Kang, Se Yun Jeong, Rhim Ryoo, Chul-Young Kim, Mi-Jeong Ahn, Kyo Bin Kang, Ki Hyun Kim

“…As part of an ongoing natural product chemical research for the discovery of bioactive secondary metabolites with novel structures, wild fruiting bodies of <i>Daedaleopsis confragosa</i> were collected and subjected to chemical and biological analyses. …”
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Diverse forage improves lipid metabolism and antioxidant capacity in goats, as revealed by metabolomics by Dicky Aldian, Laila Dini Harisa, Hiroki Mitsuishi, Ke Tian, Atsushi Iwasawa, Masato Yayota

“…It is well established that promoting the balance of nutrients and plant secondary metabolites (PSM) by feeding diverse forage physiologically improves ruminant production. …”
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Obtaining Callus Culture of Sage Medicinal (<i>Salvia officinalis</i> L.) and its Characteristics by N. S. Pivovarova, T. S. Shebitchenko, O. N. Abrosimova

“…Plant cells cultivated in vitro act as a source of valuable secondary metabolites such as phenols, alkaloids, phytosteroids, glycosides, etc. …”
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Chitosan Elicitation Impacts Flavonolignan Biosynthesis in <i>Silybum marianum</i> (L.) Gaertn Cell Suspension and Enhances Antioxidant and Anti-Inflammatory Activities of Cell Ext... by Muzamil Shah, Hasnain Jan, Samantha Drouet, Duangjai Tungmunnithum, Jafir Hussain Shirazi, Christophe Hano, Bilal Haider Abbasi

“…Chitosan is a well-known elicitor that strongly affects both secondary metabolites and biomass production by plants. The effect of chitosan on <i>S. marianum</i> cell suspension is not known yet. …”
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Therapeutic exploration of polyherbal formulation against letrozole induced PCOS rats: A mechanistic approach by Arul Balasubramanian, Sudhakar Pachiappan, Surendiran Mohan, Harikrishnan Adhikesavan, Indira Karuppasamy, Kothai Ramalingam

“…These beneficial actions are mainly attributable to the formulation's inclusion of the key secondary metabolites flavonoids and phytosterols. In conclusion, the prepared polyherbal syrup was found to be the safest and most effective alternative medicine for both endocrinal and metabolic complications of PCOS women.…”
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Antimicrobial Activity of Polyphenolic Compounds by V. G. Luzhanin, A. K. Whaley, A. O. Ponkratova, V. V. Novikova, E. A. Bezverkhniaia

“…For bibenzyls, an inverse dependence of antimicrobial activity on the number of methoxy groups was observed – the best activity among bibenzyls against the studied strains was shown by 1-(3-hydroxyphenyl)-2-(3-hydroxy-4,5-dimethoxyphenyl)ethane, which contains two methoxy groups in its structure.Conclusion. Polyphenolic secondary metabolites of plant origin belonging to the studied groups: flavonoids and O-, C-glycosides, chalcones, 9,10-dihydrophenanthrenes and bibenzyls did not show significant antimicrobial activity against the studied strains of microorganisms – S. aureus (6538 EP ATCC), E. coli (25922 ATCC) and C. albicans (885-653 NCTC). …”
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Elicitation Induced α-Amyrin Synthesis in <i>Tylophora indica</i> In Vitro Cultures and Comparative Phytochemical Analyses of In Vivo and Micropropagated Plants by Jyoti Mamgain, Abdul Mujib, Yashika Bansal, Basit Gulzar, Nadia Zafar, Rukaya Syeed, Ali Alsughayyir, Yaser Hassan Dewir

“…Therefore, these results suggest future opportunities of elicitors in scaling up the production of important secondary metabolites to meet the requirements of the pharmaceutical industry.…”
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