Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach by Yuliang Hu, Jinping Bao, Dongyu Tang, Shushan Gao, Fei Wang, Zhongtao Ding, Chengsen Cui

“…(<i>R</i>)-Homobenzylic amines are key structural motifs present in (<i>R</i>)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. …”
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Striking Neurochemical and Behavioral Differences in the Mode of Action of Selegiline and Rasagiline by Laszlo G. Harsing, Julia Timar, Ildiko Miklya

Subjects: “…selegiline…”
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Efficacy and safety of selegiline for the treatment of Parkinson's disease: A systematic review and meta-analysis by Ke Wang, Ke Wang, Ze-Hui Liu, Ze-Hui Liu, Xin-Ya Li, Yan-Fei Li, Jia-Rui Li, Jiao-Jiao Hui, Jiao-Jiao Hui, Jing-Xuan Li, Jing-Xuan Li, Jun-Wen Zhou, Jun-Wen Zhou, Zhan-Miao Yi, Zhan-Miao Yi

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Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study by Jinru Zhang, Juping Chen, Jia Li, Jian Li, Hong Miao, Xiangyang Zhu, Meng Meng, Yang Han, Jing Chen, Xiaoyu Cheng, Kangping Xiong, Hong Jin, Weifeng Luo, Chengjie Mao, Chunfeng Liu, Xiuyuan Hao, Rongman Jia

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The effect of selegiline in the treatment of people with Alzheimer's disease: a meta-analysis of published trials. by Wilcock, G, Birks, J, Whitehead, A, Evans, S

“…Study Selection Unconfounded, double-blind, randomised trials of selegiline compared with placebo reported before 31 December 1998. …”

Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice by Judit Szepesy, Viktória Humli, János Farkas, Ildikó Miklya, Júlia Tímár, Tamás Tábi, Anita Gáborján, Gábor Polony, Ágnes Szirmai, László Tamás, László Köles, Elek Sylvester Vizi, Tibor Zelles

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Simple and sensitive high performance liquid chromatographic (HPLC) method for the determination of the selegiline in human plasma by Hossein Danafar

Subjects: “…selegiline…”
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Selegiline induced differentiation of rat bone marrow mesenchymal stem cells to dopaminergic neurons in vitro by Dhiya Altememy, Maryam Haji Ghasem Kashani, Pegah Khosravian

“…The results showed that selegiline with a dose of 10-8 M for 48 hours can lead to dopaminergic differentiation in rBMSCs.…”
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Effects of (-)deprenyl (selegiline) on acetylcholinesterase and Na(+),K(+)-ATPase activities in adult rat whole brain. by Antoniades, C, Carageorgiou, H, Tsakiris, S

Nose to brain delivery of selegiline loaded PLGA/lipid nanoparticles : Synthesis, characterisation and brain pharmacokinetics evaluation by Raman, Subashini, Khan, Arshad Ali, Mahmood, Syed

“…The primary treatment strategy for Parkinson's disease involves the therapy of an MAO-B inhibitor molecule, selegiline. The present research aims to fabricate selegiline loaded polymeric (PLGA) nanoparticles (SPNPs) and selegiline loaded lipid-PLGA hybrid nanoparticles (SLPNPs) while using the single emulsion solvent evaporation method. …”
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Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies by Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Nagai

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A nano-carbon electrode optimized for adsorptive stripping voltammetry: Application to detection of the stimulant selegiline in authentic saliva by Dos Santos, W, Amin, H, Compton, R

“…The detection of the stimulant selegiline, which is a prohibited drug for athletes in sports competitions, is used as model for application of the proposed electrochemical method in saliva samples. …”

Selegiline acts as neuroprotective agent against methamphetamine-prompted mood and cognitive related behavior and neurotoxicity in rats: Involvement of CREB/BDNF and Akt/GSK3 signal pathways by Saba Feizipour, Sarvenaz Sobhani, Shafagh Mehrafza, Mina Gholami, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Reza Davoudizadeh

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سلژیلین عامل افزایش تمایز سلول‌های بنیادی عصبی موش به نورون by Kambiz Hassanzadeh, Rohallah Moloudi, Mehrnoosh Nikzaban, Hamoon Moghbel, Esmael Izadpanah

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Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations by Santosh Kumar Puttrevu, Sumit Arora, Sebastian Polak, Nikunj Kumar Patel

Subjects: “…selegiline…”
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Selegiline Modulates Lipid Metabolism by Activating AMPK Pathways of Epididymal White Adipose Tissues in HFD-Fed Obese Mice by Hye-Young Joung, Jung-Mi Oh, Min-Suk Song, Young-Bae Kwon, Sungkun Chun

Subjects: “…selegiline…”
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Selegiline Differentiates Adult Stem Cells toward Dopaminergic-Like Neurons: A Comparison between Two Cellular Niches of Hippocampal Neurogenesis by Mohammad Ghorbanian, Leila Mirzaeian, Mohammad Taghi Ghorbanian, Farzaneh Rostami

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In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer&rsquo;s Disease by Huang ST, Luo JC, Zhong GH, Teng LP, Yang CY, Tang CL, Jing L, Zhou ZB, Liu J, Jiang N

“…To explore an effective treatment for AD, a series of novel tacrine-selegiline hybrids with ChEs and MAOs inhibitory activities were designed and synthesized as multifunctional drugs.Methods: All designed compounds were evaluated in vitro for their inhibition of cholinesterases (AChE/BuChE) and monoamine oxidases (MAO-A/B) along with their blood-brain barrier permeability. …”
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Hydride Abstraction as the Rate-Limiting Step of the Irreversible Inhibition of Monoamine Oxidase B by Rasagiline and Selegiline: A Computational Empirical Valence Bond Study by Tana Tandarić, Alja Prah, Jernej Stare, Janez Mavri, Robert Vianello

“…The proposed mechanism is strongly supported by the obtained free energy profiles, which confirm a higher reactivity of selegiline over rasagiline, while the calculated difference in the activation Gibbs energies of ΔΔ<b><i>G</i></b>^‡ = 3.1 kcal mol⁻¹ is found to be in very good agreement with that from the measured literature <b><i>k</i></b>_inact values that predict a 1.7 kcal mol⁻¹ higher selegiline reactivity. …”
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Neuroprotective effects of selegiline agent methamphetamine-prompted mood-related behavior disorder mediated via 5-HT2 and D2 receptors by Mina Gholami, Neda Kaviani, Majid Motaghinejad, Luis Ulloa

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