Research priorities in childhood-onset lupus: results of a multidisciplinary prioritization exercise by Stacy P. Ardoin, R Paola Daly, Lyna Merzoug, Karin Tse, Kaveh Ardalan, Lisa Arkin, Andrea Knight, Tamar Rubinstein, Natasha Ruth, Scott E. Wenderfer, Aimee O. Hersh, on behalf of the Childhood Arthritis and Rheumatology Research Alliance and Lupus Foundation of America

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Comparison of crystalloid resuscitation fluids for treatment of acute brain injury: a clinical and pre-clinical systematic review and network meta-analysis protocol by Mary Thompson, Lauralyn McIntyre, Brian Hutton, Alexandre Tran, Dianna Wolfe, Jamie Hutchison, Dean Fergusson, Alexis F. Turgeon, Shane W. English

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Translating Precision Health for Pediatrics: A Scoping Review by Mathushan Subasri, Celine Cressman, Danielle Arje, Leighton Schreyer, Erin Cooper, Komal Patel, Wendy J. Ungar, Melanie Barwick, Avram Denburg, Robin Z. Hayeems

“…This research was funded by the SickKids Precision Child Health Catalyst Grant.…”
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Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity by Xin-Lu Yin, Hui-Qun Jie, Min Liang, Li-Na Gong, Han-Wei Liu, Hao-Lai Pan, Ya-Zhi Xing, Hai-Bo Shi, Chun-Yan Li, Lu-Yang Wang, Shan-Kai Yin

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Reaching health facilities in situations of emergency: qualitative study capturing experiences of pregnant women in Africa’s largest megacity by Aduragbemi Banke-Thomas, Mobolanle Balogun, Ololade Wright, Babatunde Ajayi, Ibukun-Oluwa Omolade Abejirinde, Abimbola Olaniran, Rokibat Olabisi Giwa-Ayedun, Bilikisu Odusanya, Bosede Bukola Afolabi

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Global prevalence of physical activity for children and adolescents; inconsistencies, research gaps, and recommendations: a narrative review by Salomé Aubert, Javier Brazo-Sayavera, Silvia A. González, Ian Janssen, Taru Manyanga, Adewale L. Oyeyemi, Patrick Picard, Lauren B. Sherar, Evan Turner, Mark S. Tremblay

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Bridging the Access Gap for Comprehensive Sickle Cell Disease Management Across Sub-Saharan Africa: Learnings for Other Global Health Interventions? by Lutz Hegemann, Vas Narasimhan, Kwaku Marfo, Patrick Kuma-Aboagye, Solomon Ofori-Acquah, Isaac Odame

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Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B by J.J. David Ho, Nathan C. Balukoff, Grissel Cervantes, Petrice D. Malcolm, Jonathan R. Krieger, Stephen Lee

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Correlation of Electrophysiological and Fluorescence-Based Measurements of Modulator Efficacy in Nasal Epithelial Cultures Derived from People with Cystic Fibrosis by Tarini N. A. Gunawardena, Zoltán Bozóky, Claire Bartlett, Hong Ouyang, Paul D. W. Eckford, Theo J. Moraes, Felix Ratjen, Tanja Gonska, Christine E. Bear

“…These cultures were obtained through a bioresource called the Cystic Fibrosis Canada-Sick Kids Program in Individual CF Therapy (CFIT). …”
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Associations between dimensions of empowerment and nutritional status among married adolescent girls in East Africa: a structural equation modelling study by Alison Y. Riddle, Wenshan Li, Zulfiqar A. Bhutta, Carol Vlassoff, Monica Taljaard, Elizabeth Kristjansson, Vivian Welch, George A. Wells

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Screening for psychosocial risk in caregivers of children with medical complexity during the COVID-19 pandemic: a cross-sectional study by Julia Orkin, Rahul Verma, Reshma Amin, Taylor Robertson, Natalie Pitch, Laura Davidson, Gregory Anagnostopoulos, Kanokkarn Sunkonkit, Adam Qazi, Munazzah Ambreen, Samantha Mekhuri, Michael R Miller

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Increased vs. Standard Dose of Iron in Ready-to-Use Therapeutic Foods for the Treatment of Severe Acute Malnutrition in a Community Setting: A Systematic Review and Meta-Analysis by Aamer Imdad, Jaimie L. Rogner, Melissa François, Shehzad Ahmed, Abigail Smith, Olivia J. Tsistinas, Emily Tanner-Smith, Jai K. Das, Fanny F. Chen, Zulfiqar Ahmed Bhutta

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Cost of Utilising Maternal Health Services in Low- and Middle-Income Countries: A Systematic Review by Aduragbemi Banke-Thomas, Francis Ifeanyi Ayomoh, Ibukun-Oluwa Omolade Abejirinde, Oluwasola Banke-Thomas, Ejemai Amaize Eboreime, Charles Anawo Ameh

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The cost of maternal health services in low-income and middle-income countries from a provider’s perspective: a systematic review by Ejemai Amaize Eboreime, Ibukun-Oluwa Omolade Abejirinde, Oluwasola Banke-Thomas, Charles Anawo Ameh, Francis Ifeanyi Ayomoh

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The Needs and Experiences of Post-Treatment Adolescent and Young Adult Cancer Survivors by Jennifer M Jones, Margaret Fitch, Jared Bongard, Manjula Maganti, Abha Gupta, Norma D’Agostino, Chana Korenblum

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Pediatric Chronic Tracheostomy Care: An Evaluation of an Innovative Competency-Based Education Program for Community Health Care Providers by Jenny Y. Shi, Julia Orkin, Catharine M. Walsh, Stephanie Chu, Krista Keilty, Sandra McKay, Cora Mocanu, Adam Qazi, Munazzah Ambreen, Reshma Amin

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A Simulation Toolkit for Testing the Sensitivity and Accuracy of Corticometry Pipelines by Mona OmidYeganeh, Najmeh Khalili-Mahani, Najmeh Khalili-Mahani, Patrick Bermudez, Alison Ross, Claude Lepage, Robert D. Vincent, S. Jeon, Lindsay B. Lewis, S. Das, Alex P. Zijdenbos, Pierre Rioux, Reza Adalat, Matthijs C. Van Eede, Alan C. Evans

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Characterization of exosomes derived from Toxoplasma gondii and their functions in modulating immune responses by Li Y, Liu Y, Xiu F, Wang J, Cong H, He S, Shi Y, Wang X, Li X, Zhou H

“…Yawen Li,1,* Yuan Liu,1,2,* Fangming Xiu,3 Jianing Wang,4 Hua Cong,1 Shenyi He,1 Yongyu Shi,4 Xiaoyan Wang,4 Xun Li,5 Huaiyu Zhou1 1Department of Pathogen Biology, School of Basic Medical Sciences, Shandong University, Shandong, People’s Republic of China; 2Clinical Laboratory, The People’s Hospital of Changle, Shandong, People’s Republic of China; 3Translational Medicine, SickKids Research Institute, the Hospital for Sick Children Toronto, OT, Canada; 4Department of Immunology, School of Basic Medical Sciences, Shandong University, Shandong, People’s Republic of China; 5Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Shandong, People’s Republic of China *These authors contributed equally to this work Introduction: Exosomes are nanograde membrane-bound vesicles secreted from most cell types through the fusion of multivesicular bodies with plasma membranes. …”
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Interim guidelines for the assessment and treatment of pain in children with multiple sclerosis by Catherine Stratton, Areti Vassilopoulos, Areti Vassilopoulos, J. Nicholas Brenton, Kirsten Potter, Wendy Vargas, Wendy Vargas, Heather Rumm, Andrea Bartels, Mary Bailey, Charles Odonkor, Charles Odonkor, Sharon Stoll, Sharon Stoll, E. William T. Zempsky, E. William T. Zempsky, E. Ann Yeh, E. Ann Yeh, Naila Makhani, Naila Makhani

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Retraction of COVID-19 Pharmacoepidemiology Research Could Have Been Avoided by Effective Use of Reporting Guidelines by Benchimol EI, Moher D, Ehrenstein V, Langan SM

“…Eric I Benchimol,1– 3 David Moher,4,5 Vera Ehrenstein,6 Sinéad M Langan7 1Department of Paediatrics, University of Toronto, Toronto, Canada; 2Child Health Evaluative Sciences, SickKids Research Institute, and Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Canada; 3ICES, Toronto, Canada; 4School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; 5Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; 6Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark; 7Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKCorrespondence: Eric I BenchimolDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, CanadaTel +1 416813-1500Fax +1 416813-4972Email eric.benchimol@sickkids.caIntroduction: Two recent high-profile publications (and subsequent retractions) of pharmacoepidemiology studies reporting the effectiveness and risk of hydroxychloroquine in COVID-19 patients received international media attention. …”
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