Signal regulatory proteins in the immune system. by van Beek, E, Cochrane, F, Barclay, N, van den Berg, T

“…Signal regulatory proteins (SIRPs) constitute a family of transmembrane glycoproteins with extracellular Ig-like domains. …”

A nomenclature for signal regulatory protein family members. by van den Berg, T, van Beek, E, Bühring, H, Colonna, M, Hamaguchi, M, Howard, C, Kasuga, M, Liu, Y, Matozaki, T, Neel, BG, Parkos, C, Sano, S, Vignery, A, Vivier, E, Wright, M, Zawatzky, R, Barclay, N

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. by Julian Alvarez-Zarate, Hanke L Matlung, Takashi Matozaki, Taco W Kuijpers, Isabelle Maridonneau-Parini, Timo K van den Berg

“…Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. …”
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Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function. by Barclay, N

Structure of signal-regulatory protein alpha: a link to antigen receptor evolution. by Hatherley, D, Graham, S, Harlos, K, Stuart, D, Barclay, N

“…Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. …”

Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells. by Lahoud, M, Proietto, A, Gartlan, K, Kitsoulis, S, Curtis, J, Wettenhall, J, Sofi, M, Daunt, C, O'keeffe, M, Caminschi, I, Satterley, K, Rizzitelli, A, Schnorrer, P, Hinohara, A, Yamaguchi, Y, Wu, L, Smyth, G, Handman, E, Shortman, K, Wright, MD

“…The gene expression profiles of the three splenic conventional DC (cDC) subsets were compared by microarray hybridization and two genes encoding signal regulatory protein beta (Sirpbeta1 and Sirpbeta4) molecules were identified as differentially expressed in CD8(-) cDC. …”

Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity by Nienke Visser, Levi Collin Nelemans, Yuan He, Harm Jan Lourens, Macarena González Corrales, Gerwin Huls, Valerie R. Wiersma, Jan Jacob Schuringa, Edwin Bremer

“…In recent years, the therapeutic (re)activation of innate anticancer immunity has gained prominence, with therapeutic blocking of the interaction of Signal Regulatory Protein (SIRP)-α with its ligand CD47 yielding complete responses in refractory and relapsed B cell lymphoma patients. …”
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Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. by Hatherley, D, Graham, S, Turner, J, Harlos, K, Stuart, D, Barclay, N

“…We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresponding regions in SIRPalpha. …”

Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment by Nettleship, J, Ren, J, Scott, D, Rahman, N, Hatherley, D, Zhao, Y, Stuart, D, Barclay, N, Owens, R

“…<p><strong>Background</strong>: Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. …”

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha by Karen De Vlaminck, Karen De Vlaminck, Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Ana Rita Pombo Antunes, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Isabelle Scheyltjens, Isabelle Scheyltjens, Isabelle Scheyltjens, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, Kiavash Movahedi, Kiavash Movahedi, Geert Raes, Geert Raes

Subjects: “…signal regulatory protein alpha…”
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Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. by Nicolás Sarute, Han Cheng, Zhonghao Yan, Karen Salas-Briceno, Justin Richner, Lijun Rong, Susan R Ross

“…Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. …”
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Detection of Signal Regulatory Protein α in Saimiri sciureus (Squirrel Monkey) by Anti-Human Monoclonal Antibody by Hugo Amorim dos Santos de Souza, Edmar Henrique Costa-Correa, Cesare Bianco-Junior, Márcia Cristina Ribeiro Andrade, Josué da Costa Lima-Junior, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Paulo Renato Rivas Totino

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Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression by Yan Lin, Yan Lin, Yan Lin, Jun-Long Zhao, Jun-Long Zhao, Qi-Jun Zheng, Xun Jiang, Jiao Tian, Shi-Qian Liang, Hong-Wei Guo, Hong-Yan Qin, Ying-Min Liang, Hua Han, Hua Han

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Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47. by Hatherley, D, Lea, S, Johnson, S, Barclay, N

“…CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. …”

The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target. by Barclay, N, Van den Berg, T

Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis. by Dan-Qing Liu, Li-Min Li, Ya-Lan Guo, Rui Bai, Chen Wang, Zhen Bian, Chen-Yu Zhang, Ke Zen

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Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria. by W Ray Waters, Mitchell V Palmer, Brian J Nonnecke, Tyler C Thacker, D Mark Estes, Michelle H Larsen, William R Jacobs, Peter Andersen, James McNair, F C Minion, Konstantin P Lyashchenko, R Glyn Hewinson, H Martin Vordermeier, Randy E Sacco

“…In tissue culture models, signal regulatory protein (SIRP)alpha (also referred to as macrophage fusion receptor or CD172a) is essential for multi-nucleate giant cell formation. …”
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Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. by Brooke, G, Holbrook, J, Brown, M, Barclay, N

“…Two closely related proteins, signal regulatory protein alpha (SIRPalpha; SHPS-1/CD172) and SIRPbeta, have been described in humans. …”

Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family by Brooke, G, Holbrook, J, Brown, M, Barclay, A

“…Two closely related proteins, signal regulatory protein α (SIRPα; SHPS-1/CD172) and SIRPβ, have been described in humans. …”

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors by Stephen K Horrigan, Reproducibility Project: Cancer Biology

“…In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper “The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors “(Willingham et al., 2012). …”
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