Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. by Julian Alvarez-Zarate, Hanke L Matlung, Takashi Matozaki, Taco W Kuijpers, Isabelle Maridonneau-Parini, Timo K van den Berg

“…Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. …”
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Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function. by Barclay, N

Structure of signal-regulatory protein alpha: a link to antigen receptor evolution. by Hatherley, D, Graham, S, Harlos, K, Stuart, D, Barclay, N

“…Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. …”

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha by Karen De Vlaminck, Karen De Vlaminck, Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Ana Rita Pombo Antunes, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Isabelle Scheyltjens, Isabelle Scheyltjens, Isabelle Scheyltjens, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, Kiavash Movahedi, Kiavash Movahedi, Geert Raes, Geert Raes

Subjects: “…signal regulatory protein alpha…”
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Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. by Nicolás Sarute, Han Cheng, Zhonghao Yan, Karen Salas-Briceno, Justin Richner, Lijun Rong, Susan R Ross

“…Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. …”
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The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target. by Barclay, N, Van den Berg, T

Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis. by Dan-Qing Liu, Li-Min Li, Ya-Lan Guo, Rui Bai, Chen Wang, Zhen Bian, Chen-Yu Zhang, Ke Zen

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Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria. by W Ray Waters, Mitchell V Palmer, Brian J Nonnecke, Tyler C Thacker, D Mark Estes, Michelle H Larsen, William R Jacobs, Peter Andersen, James McNair, F C Minion, Konstantin P Lyashchenko, R Glyn Hewinson, H Martin Vordermeier, Randy E Sacco

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Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors by Stephen K Horrigan, Reproducibility Project: Cancer Biology

“…In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper “The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors “(Willingham et al., 2012). …”
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Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains by Jan Koski, Farhana Jahan, Annu Luostarinen, Diana Schenkwein, Seppo Ylä-Herttuala, Seppo Ylä-Herttuala, Helka Göös, Hector Monzo, Päivi M. Ojala, Pilvi Maliniemi, Matti Korhonen

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A New Serum Macrophage Checkpoint Biomarker for Innate Immunotherapy: Soluble Signal-Regulatory Protein Alpha (sSIRPα) by Yoanna V. Vladimirova, Marie K. Mølmer, Kristian W. Antonsen, Niels Møller, Nikolaj Rittig, Marlene C. Nielsen, Holger J. Møller

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The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors. by Hatherley, D, Harlos, K, Dunlop, D, Stuart, D, Barclay, N

Anomalous Levels of CD47/Signal Regulatory Protein Alpha in the Hippocampus Lead to Excess Microglial Engulfment in Mouse Model of Perioperative Neurocognitive Disorders by Min Shui, Yi Sun, Dandan Lin, Ziyi Xue, Jianhui Liu, Anshi Wu, Changwei Wei

“…Cluster of differentiation 47 (CD47), which can bind to its receptor signal regulatory protein alpha (SIRPα) and generate “do not eat me” signal, protects synapses from excessive pruning. …”
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Lower Oligomeric Form of Surfactant Protein D in Murine Acute Lung Injury Induces M1 Subtype Macrophages Through Calreticulin/p38 MAPK Signaling Pathway by Dandan Li, Dandan Li, Linyue Pan, Xiaoju Zhang, Zhilong Jiang

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SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies by Rima M. Saliba, Samer A. Srour, Uri Greenbaum, Uri Greenbaum, Qing Ma, Yudith Carmazzi, Michael Moller, Janet Wood, Stefan O. Ciurea, Piyanuch Kongtim, Piyanuch Kongtim, Gabriela Rondon, Dan Li, Supawee Saengboon, Amin M. Alousi, Katayoun Rezvani, Elizabeth J. Shpall, Kai Cao, Richard E. Champlin, Jun Zou

Subjects: “…signal regulatory protein alpha…”
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S219: FIRST CLINICAL STUDY OF THE ANTI-SIGNAL REGULATORY PROTEIN-ALPHA (SIRPΑ) ANTIBODY CC-95251 COMBINED WITH RITUXIMAB IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) NON-HODGKIN LYMPHOMA (NHL) by P. Strati, E. Hawkes, N. Ghosh, J. Tuscano, Q. Chu, M. A. Anderson, A. Patel, M. R. Burgess, K. Hege, S. Chhagan, S. Boyanapalli, T. Day, F. Shen, A. Mehta

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Identification of an Immature Subset of PMN-MDSC Correlated to Response to Checkpoint Inhibitor Therapy in Patients with Metastatic Melanoma by Françoise Gondois-Rey, Magali Paul, Florence Alcaraz, Sarah Bourass, Jilliana Monnier, Nausicaa Malissen, Jean-Jacques Grob, Annika M. Bruger, Pierre Van Der Bruggen, Caroline Gaudy-Marqueste, Daniel Olive

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Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer by Akane Sugimura-Nagata, Akira Koshino, Satoshi Inoue, Aya Matsuo-Nagano, Masayuki Komura, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Satoru Takahashi, Kunio Kasugai, Kenji Kasai, Shingo Inaguma

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miR-148a Affects Polarization of THP-1-Derived Macrophages and Reduces Recruitment of Tumor-Associated Macrophages via Targeting SIRPα by Ma D, Zhang Y, Chen G, Yan J

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A phase 1 first‐in‐human study of GS‐0189, an anti‐signal regulatory protein alpha (SIRPα) monoclonal antibody, in patients with relapsed/refractory (R/R) non‐Hodgkin lymphoma (NHL) by Mayur Narkhede, Nancy L. Bartlett, Sami Ibrahimi, Leslie Popplewell, Anna Seto, Jamie Bates, Yeonju Lee, Vaishnavi Ganti, Ling Han, Tianling Chen, Manish R. Patel

“…Abstract Signal regulatory protein alpha (SIRPα) is the receptor for cluster of differentiation (CD)47, a potent “don't eat me” signal for macrophages. …”
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