A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus by Meihui Xu, Roland Zuest, Sumathy Velumani, Farhana Tukijan, Ying Xiu Toh, Ramapraba Appanna, Ern Yu Tan, Daniela Cerny, Paul MacAry, Cheng-I Wang, Katja Fink

“…Katja Fink, of the Singapore Immunology Network and Nanyang Technological University, Singapore, describes this as the first time a highly neutralizing antibody has shown efficacy against all four strains. …”
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Unsupervised spatially embedded deep representation of spatial transcriptomics by Hang Xu, Huazhu Fu, Yahui Long, Kok Siong Ang, Raman Sethi, Kelvin Chong, Mengwei Li, Rom Uddamvathanak, Hong Kai Lee, Jingjing Ling, Ao Chen, Ling Shao, Longqi Liu, Jinmiao Chen

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Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals by Jackwee Lim, Kia Joo Puan, Liang Wei Wang, Karen Wei Weng Teng, Chiew Yee Loh, Kim Peng Tan, Guillaume Carissimo, Guillaume Carissimo, Yi-Hao Chan, Yi-Hao Chan, Chek Meng Poh, Chek Meng Poh, Cheryl Yi-Pin Lee, Cheryl Yi-Pin Lee, Siew-Wai Fong, Siew-Wai Fong, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Nicholas Kim-Wah Yeo, Rhonda Sin-Ling Chee, Rhonda Sin-Ling Chee, Siti Naqiah Amrun, Siti Naqiah Amrun, Zi Wei Chang, Zi Wei Chang, Matthew Zirui Tay, Matthew Zirui Tay, Anthony Torres-Ruesta, Anthony Torres-Ruesta, Anthony Torres-Ruesta, Norman Leo Fernandez, Wilson How, Anand Kumar Andiappan, Wendy Lee, Kaibo Duan, Seow-Yen Tan, Gabriel Yan, Shirin Kalimuddin, Shirin Kalimuddin, David Chien Lye, David Chien Lye, David Chien Lye, David Chien Lye, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Sean W. X. Ong, Sean W. X. Ong, Barnaby E. Young, Barnaby E. Young, Barnaby E. Young, Laurent Renia, Laurent Renia, Lisa F. P. Ng, Lisa F. P. Ng, Lisa F. P. Ng, Lisa F. P. Ng, Bernett Lee, Olaf Rötzschke

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Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma by Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen, Siew Cheng Wong

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Co‐infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium‐induced neuropathology by Teck‐Hui Teo, Shanshan W Howland, Carla Claser, Sin Yee Gun, Chek Meng Poh, Wendy WL Lee, Fok‐Moon Lum, Lisa FP Ng, Laurent Rénia

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Corrigendum: A Single-Cell Sequencing Guide for Immunologists by Peter See, Josephine Lum, Jinmiao Chen, Florent Ginhoux, Florent Ginhoux

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Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST by Yahui Long, Kok Siong Ang, Mengwei Li, Kian Long Kelvin Chong, Raman Sethi, Chengwei Zhong, Hang Xu, Zhiwei Ong, Karishma Sachaphibulkij, Ao Chen, Li Zeng, Huazhu Fu, Min Wu, Lina Hsiu Kim Lim, Longqi Liu, Jinmiao Chen

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1279 H&E-2.0: an extended application of ST-net to liver cancer and its generalizability by Joe Yeong, Jeffrey Lim, Mai Chan Lau, Yiyu Cai, Felicia Wee, Chan Way Ng, Menaka Priyadharsani Rajapakse, Samuel Lee Cong, Bok Leong Chua, Nicholas Da Zhi Ang, Thian Juea Reiner Sim, Chu Yuan, Solomonraj Wilson, Abu Bakr Bakr Azam

Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma by Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmiao Chen, Suet Mien Tan, Siew Cheng Wong

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Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate by Yi‐Hao Chan, Teck‐Hui Teo, Age Utt, Jeslin JL Tan, Siti Naqiah Amrun, Farhana Abu Bakar, Wearn‐Xin Yee, Etienne Becht, Cheryl Yi‐Pin Lee, Bernett Lee, Ravisankar Rajarethinam, Evan Newell, Andres Merits, Guillaume Carissimo, Fok‐Moon Lum, Lisa FP Ng

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Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination by Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger, Olaf Rötzschke

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Functionally diverse human T cells recognize non-microbial antigens presented by MR1 by Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero

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Dengue serotype cross-reactive, anti-E protein antibodies confound specific immune memory for one year after infection by Ying Xiu eToh, Victor eGan, Thavamalar eBalakrishnan, Roland eZuest, Michael ePoidinger, Solomonraj eWilson, Ramapraba eAppanna, Tun Linn eThein, Adrian Keng-Yeow Ong, Lee Ching eNg, Yee Sin eLeo, Yee Sin eLeo, Yee Sin eLeo, Katja eFink

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Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis by Hong Sheng Quah, Elaine Yiqun Cao, Lisda Suteja, Constance H. Li, Hui Sun Leong, Fui Teen Chong, Shilpi Gupta, Camille Arcinas, John F. Ouyang, Vivian Ang, Teja Celhar, Yunqian Zhao, Hui Chen Tay, Jerry Chan, Takeshi Takahashi, Daniel S. W. Tan, Subhra K. Biswas, Owen J. L. Rackham, N. Gopalakrishna Iyer

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Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes by Bezaleel Mambwe, Bezaleel Mambwe, Kurt Neo, Hanif Javanmard Khameneh, Keith Weng Kit Leong, Mariasilvia Colantuoni, Mariasilvia Colantuoni, Maurizio Vacca, Richmond Muimo, Alessandra Mortellaro, Alessandra Mortellaro

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mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines by Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

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Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells by Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. Wright, Anis Larbi, Sylvia L. F. Pender

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1282 H&E 2.0 virtual staining of CD3+ T cells: improving cell labeling for precise model training by Joe Yeong, Bernett Lee, Inti Zlobec, Jeffrey Lim, Mai Chan Lau, Felicia Wee, Chan Way Ng, Xinyun Feng, Marcia Zhang, Willa Yim, Menaka Priyadharsani Rajapakse, Olaf Rotzchke

Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma by Wendy W. L. Lee, Jing Quan Lim, Jing Quan Lim, Tiffany P. L. Tang, Daryl Tan, Ser Mei Koh, Kia Joo Puan, Liang Wei Wang, Jackwee Lim, Kim Peng Tan, Wee Joo Chng, Wee Joo Chng, Wee Joo Chng, Soon Thye Lim, Soon Thye Lim, Choon Kiat Ong, Choon Kiat Ong, Olaf Rotzschke, Olaf Rotzschke

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Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis by Wenn-Chyau Lee, Bruce Russell, Radoslaw Mikolaj Sobota, Khairunnisa Ghaffar, Shanshan W Howland, Zi Xin Wong, Alexander G Maier, Dominique Dorin-Semblat, Subhra Biswas, Benoit Gamain, Yee-Ling Lau, Benoit Malleret, Cindy Chu, François Nosten, Laurent Renia

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