Single-cell genomics of a bloom-forming phytoplankton species reveals population genetic structure across continents by Gollnisch, R, Ahrén, D, Rengefors, K

“…We amplified over 900 single-cell genomes from 25 lake populations across Europe and the United States and identified two distinct population clusters, one in Europe and another in the United States. …”

Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies by Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka

Subjects: Get full text

Data-driven detection of age-related arbitrary monotonic changes in single-cell gene expression distributions by Jian Hao Cheng, Daigo Okada

Subjects: Get full text

A novel computational tool for tracking cancer energy hijacking from immune cells by Hongyi Zhang, Bo Li

Subjects: Get full text

Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution by M. J. Higgs, M. J. Hill, R. M. John, A. R. Isles

Subjects: Get full text

Single-Cell Transcriptomics Bioinformatics and Computational Challenges by Lana Garmire, Olivier Bertrand Poirion, Xun Zhu, Travers Ching

Subjects: Get full text

Cellograph: a semi-supervised approach to analyzing multi-condition single-cell RNA-sequencing data using graph neural networks by Jamshaid A. Shahir, Natalie Stanley, Jeremy E. Purvis

Subjects: Get full text

Identifying tumor cells at the single-cell level using machine learning by Jan Dohmen, Artem Baranovskii, Jonathan Ronen, Bora Uyar, Vedran Franke, Altuna Akalin

Subjects: “…Single-cell genomics…”
Get full text

Computational Methods for Single-cell DNA Methylome Analysis by Waleed Iqbal, Wanding Zhou

Subjects: “…Single-cell genomics…”
Get full text

The Human Cell Atlas: making ‘cell space’ for disease by Chris P. Ponting

Subjects: Get full text

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencing by Masato Kogawa, Yohei Nishikawa, Yohei Nishikawa, Tatsuya Saeki, Takuya Yoda, Koji Arikawa, Haruko Takeyama, Haruko Takeyama, Haruko Takeyama, Haruko Takeyama, Masahito Hosokawa, Masahito Hosokawa, Masahito Hosokawa, Masahito Hosokawa, Masahito Hosokawa

Subjects: Get full text

Improved environmental genomes via integration of metagenomic and single-cell assemblies by Daniel Richard Mende, Frank O'Neill Aylward, John M Eppley, Torben N Nielsen, Edward F. DeLong

Subjects: Get full text

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral by Keigo Ide, Yohei Nishikawa, Toru Maruyama, Yuko Tsukada, Masato Kogawa, Hiroki Takeda, Haruka Ito, Ryota Wagatsuma, Rimi Miyaoka, Yoshikatsu Nakano, Koji Kinjo, Michihiro Ito, Masahito Hosokawa, Kei Yura, Shoichiro Suda, Haruko Takeyama

“…Results In this study, we applied a novel single-cell genomics technique using droplet microfluidics to obtain single-cell amplified genomes (SAGs) for uncultured coral-associated Endozoicomonas spp. …”
Get full text

Chromosomal Instability Estimation Based on Next Generation Sequencing and Single Cell Genome Wide Copy Number Variation Analysis. by Stephanie B Greene, Angel E Dago, Laura J Leitz, Yipeng Wang, Jerry Lee, Shannon L Werner, Steven Gendreau, Premal Patel, Shidong Jia, Liangxuan Zhang, Eric K Tucker, Michael Malchiodi, Ryon P Graf, Ryan Dittamore, Dena Marrinucci, Mark Landers

“…For proof of concept, prostate cancer cell lines, LNCaP, PC3 and VCaP, were spiked into healthy donor blood to create mock patient-like samples for downstream single cell genomic analysis. In addition, samples from seven metastatic castration resistant prostate cancer (mCRPC) patients were included to evaluate clinical feasibility. …”
Get full text

Oncogenes and cancer associated thrombosis: what can we learn from single cell genomics about risks and mechanisms? by Nadim Tawil, Abdulshakour Mohammadnia, Janusz Rak

Get full text

Genomic Characteristics and Potential Metabolic Adaptations of Hadal Trench Roseobacter and Alteromonas Bacteria Based on Single-Cell Genomics Analyses by Mingming Chen, Yu Song, Xiaoyuan Feng, Kai Tang, Nianzhi Jiao, Jiwei Tian, Yao Zhang

Subjects: “…single-cell genome…”
Get full text

Oceanic Crustal Fluid Single Cell Genomics Complements Metagenomic and Metatranscriptomic Surveys With Orders of Magnitude Less Sample Volume by Timothy D’Angelo, Jacqueline Goordial, Jacqueline Goordial, Nicole J. Poulton, Lauren Seyler, Lauren Seyler, Julie A. Huber, Ramunas Stepanauskas, Beth N. Orcutt

Subjects: Get full text

Correction to: scBFA: modeling detection patterns to mitigate technical noise in large-scale single-cell genomics data by Ruoxin Li, Gerald Quon

Get full text

A single-cell genomic based investigation of immune cells in the aorta and adipose tissue during metabolic disease progression by Zurke, YX

Phylogeography, salinity adaptations and metabolic potential of the Candidate Division KB1 Bacteria based on a partial single cell genome. by Lisa M Nigro, Andrew S Hyde, Barbara J. MacGregor, Andreas Teske

Get full text