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    Integrated Design for Flood Risk and Spatial Quality Enhancement by Anne Loes Nillesen

    Published 2018-12-01
    “…They vary from elaborate embedment studies (Scheveningen) to a more condensed research-by-design approach that could be included in the developed method (Sliedrecht & Houston). In the design studies, the following method is applied to a greater or lesser extent: Creation of an inventory of the spatial-economic ambitions and challenges of the location Creation of an overview of possible (and viable) technical options for dike reinforcements Performing a design study for the spatial implementation of each intervention Reflecting on the pros and cons of the applications The spatial ambition map developed for the Alblasserwaard-Vijfheerenlanden case study, which is included in this chapter, is a valuable example of how to inventory the spatial-economic ambitions and challenges of the location. …”
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    Myoclonic-Atonic Epilepsy Caused by a Novel de Novo Heterozygous Missense Variant in the SLC6A1 Gene: Brief Discussion of the Literature and Detailed Case Description of a Severely... by Verhoeven W, Zuijdam J, Scheick A, van Nieuwenhuijsen F, Zwemer AS, Pfundt R, Egger J

    Published 2022-12-01
    “…Willem Verhoeven,1– 3 José Zuijdam,4 Anneke Scheick,4 Frederiek van Nieuwenhuijsen,5 Anne-Suus Zwemer,5 Rolph Pfundt,6,7 Jos Egger3,6,7 1Department of Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Centre for Consultation and Expertise, Utrecht, the Netherlands; 3Vincent van Gogh Centre of Excellence for Neuropsychiatry, Venray, the Netherlands; 4Raphael Institute Breidablick, Centre for People with Intellectual Disabilities, Middenbeemster, the Netherlands; 5ASVZ, Centre for People with Intellectual Disabilities, Sliedrecht, the Netherlands; 6Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands; 7Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the NetherlandsCorrespondence: Willem Verhoeven, Centre of Excellence for Neuropsychiatry, Stationsweg 46, Venray, 5803 AC, the Netherlands, Tel +31651156556, Fax +31478584765, Email wmaverhoeven@planet.nlIntroduction: Diagnostic exome sequencing has yielded over the past decades a great number of molecular diagnoses for genetic disorders in which both intellectual disability and epilepsy are present. …”
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