A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins [version 1; peer review: 2 approved] by Ayato Sato, Tsuyoshi Hirota, Yoshiko Nagai, Shinsuke Inuki, Moeri Yagi, Simon Miller

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A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins [version 2; peer review: 2 approved] by Ayato Sato, Tsuyoshi Hirota, Yoshiko Nagai, Shinsuke Inuki, Moeri Yagi, Simon Miller

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Targeting SOST using a small-molecule compound retards breast cancer bone metastasis by Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Zhou, Jiawen Bu, Xudong Zhu, Xiaoying Zhang, Xiaofan Jiang, Chao Liu, Xinnan Li, Yang Liu, Yongliang Yang, Caigang Liu

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Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds by Lijuan Zhang, Lijuan Zhang, Yuxuan Zhu, Yuxuan Zhu, Jiahui Zhang, Jiahui Zhang, Lan Zhang, Lu Chen, Lu Chen

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Posttranslational regulatory mechanism of PD-L1 in cancers and associated opportunities for novel small-molecule therapeutics by Cai Minchen, Xu Mengting, Yu Dianping, Wang Qun, Liu Sanhong

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Antibiofilm Activity of Small-Molecule ZY-214-4 Against Staphylococcus aureus by Jingyi Yu, Lulin Rao, Lingling Zhan, Yan Zhou, Yinjuan Guo, Yinjuan Guo, Xiaocui Wu, Xiaocui Wu, Zengqiang Song, Fangyou Yu, Fangyou Yu

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Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease by Kai Zhang, Shiou Zhu, Jiamei Li, Tingting Jiang, Lu Feng, Junping Pei, Guan Wang, Liang Ouyang, Bo Liu

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Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin by Yan Li, Nannan Liu, Yao Qian, Chenyang Jiao, Jiashu Yang, Xiangbao Meng, Yang Sun, Qiang Xu, Wen Liu, Jian Cui, Wenjie Guo

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Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived by Pengtao Liu, Bo Zhang, Yuanqiang Li, Qipeng Yuan

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Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR by Xiuman Zhou, Jiangfeng Du, Hongfei Wang, Chunxia Chen, Ling Jiao, Xiangrui Cheng, Xiaowen Zhou, Shaomeng Chen, Shanshan Gou, Wenshan Zhao, Wenjie Zhai, Junhui Chen, Yanfeng Gao

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The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants by Jing Pu, Xiaoyang He, Wei Xu, Cong Wang, Qiaoshuai Lan, Chen Hua, Kai Wang, Lu Lu, Shibo Jiang

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Discovery of a small-molecule NDR1 agonist for prostate cancer therapy by Yang Bai, Yang Bai, Xiuyuan Sui, Xiuyuan Sui, Zuodong Xuan, Zuodong Xuan, Yifan Du, Yifan Du, Meiling Fu, Meiling Fu, Zeyuan Zheng, Zeyuan Zheng, Kunao Yang, Kunao Yang, Chunlan Xu, Chunlan Xu, Yankuo Liu, Yankuo Liu, Bin Liu, Bin Liu, Min Zhong, Min Zhong, Zhengying Zhang, Zhengying Zhang, Jianzhong Zheng, Xiaoyan Hu, Lei Zhang, Huimin Sun, Huimin Sun, Chen Shao, Chen Shao

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Antimicrobial activities of a small molecule compound II-6s against oral streptococci by Jin Zhang, Xinyi Kuang, Yuanzheng Zhou, Ran Yang, Xuedong Zhou, Xian Peng, Youfu Luo, Xin Xu

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A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sitesResearch in context by Yawei Wang, Binlin Tang, Huijuan Li, Jiancheng Zheng, Can Zhang, Zeyu Yang, Xu Tan, Peng Luo, Le Ma, Yang Wang, Lei Long, Zelin Chen, Zhenliang Xiao, Lijie Ma, Jing Zhou, Yu Wang, Chunmeng Shi

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Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells by Yinghui Li, Mei He, Wenshan Zhang, Ming Yang, Yahui Ding, Shiqi Xu, Jiali Gu, Yafang Li, Jingjing Yin, Yingdai Gao

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Spliceosome inhibitor induces human hematopoietic progenitor cell reprogramming toward stemness by Liaoliao Dong, Chuijin Wei, Shumin Xiong, Ping Yu, Ren Zhou, Lin Cheng

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Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo by Fanxiang Yin, Ran Zhao, Dhilli Rao Gorja, Xiaorong Fu, Ning Lu, Hai Huang, Beibei Xu, Hanyong Chen, Jung-Hyun Shim, Kangdong Liu, Zhi Li, Kyle Vaughn Laster, Zigang Dong, Mee-Hyun Lee

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Possibility of small-molecule-based pharmacotherapy for sarcopenia by Yuka Watanabe, Yuko Miyagoe-Suzuki

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Bioinformatics and systems-biology approach to identify common pathogenic mechanisms for COVID-19 and systemic lupus erythematosus by Yinlan Wu, Yanhong Li, Yu Zhou, Xiufeng Bai, Yi Liu

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Computer-Selected Antiviral Compounds: Assessing In Vitro Efficacies against Rift Valley Fever Virus by Cigdem Alkan, Terrence O’Brien, Victor Kenyon, Tetsuro Ikegami

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