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Isolation of a high affinity neutralizing monoclonal antibody against 2009 pandemic H1N1 virus that binds at the 'Sa' antigenic site.
Published 2013-01-01“…In a competition ELISA, MA2077 competed with the binding site of the human MAb, 2D1 (isolated from a survivor of the 1918 Spanish flu pandemic) on pandemic H1N1 HA. Epitope mapping studies using yeast cell-surface display of a stable HA1 fragment, wherein 'Sa' and 'Sb' sites were independently mutated, localized the binding site of MA2077 within the 'Sa' antigenic site. …”
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Societal Impacts of Pandemics: Comparing COVID-19 With History to Focus Our Response
Published 2021-04-01“…We compare SARS-CoV-2 against three other major pandemics (1347 Black Death, 1520's new world smallpox outbreaks, and 1918 Spanish Flu pandemic) over the course of 700 years to unearth similarities and differences in pathogen, social and medical context, human response and behavior, and long-term social and economic impact that should be used to shape COVID-19 decision-making. …”
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Topological and Thermodynamic Entropy Measures for COVID-19 Pandemic through Graph Theory
Published 2020-12-01“…Our plots of entropy and logarithms of topological indices of pandemic trees accentuate the underlying severity of COVID-19 over the 1918 Spanish flu pandemic.…”
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Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach
Published 2020-11-01“…The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and there is no cure or vaccine to date. …”
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1 to 1, 11,111 Covid sample testing; Decoding the testing matrix!
Published 2021-03-01“…Almost 100 yrs. after the 1918 Spanish Flu Pandemic, world is witnessing “Covid-19”, another Pandemic of similar scale. …”
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The beginning and ending of a respiratory viral pandemic‐lessons from the Spanish flu
Published 2022-05-01“…It is thus tempting to look into the development of historical viral respiratory pandemics for insight into the dynamic of pandemics. The Spanish flu pandemic of 1918 caused by the influenza virus H1N1 can here serve as a potential model case. …”
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A primer on using mathematics to understand COVID-19 dynamics: Modeling, analysis and simulations
Published 2021-01-01“…It became the most important public health challenge facing mankind since the 1918 Spanish flu pandemic. Various theoretical and empirical approaches have been designed and used to gain insight into the transmission dynamics and control of the pandemic. …”
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Blue Dot Artificial Intelligence and Corona Virus Corona Crisis Management
Published 2020-10-01“…Hence, openness, cooperation, exchange of experiences, and serious participation in uniting efforts are considered as the gateway to developing solutions to the crisis that humankind is going through.ImportanceArtificial intelligence applications have proven their importance in the face of the most serious epidemic facing humanity in the aftermath of the Spanish flu pandemic in the year 1920. These applications were characterized by accuracy, organization, rigorous comparisons and reliable results. …”
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Fc-mediated functions and the treatment of severe respiratory viral infections with passive immunotherapy – a balancing act
Published 2023-11-01“…Passive immunotherapies have been used to treat severe respiratory infections for over a century, with convalescent blood products from recovered individuals given to patients with influenza-related pneumonia as long ago as the Spanish flu pandemic. However, passive immunotherapy with convalescent plasma or hyperimmune intravenous immunoglobulin (hIVIG) has not provided unequivocal evidence of a clinical benefit for severe respiratory infections including influenza and COVID-19. …”
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A One Health strategy for emerging infectious diseases based on the COVID-19 outbreak
Published 2022-06-01“…In terms of impact, the COVID-19 pandemic is second only to the Spanish Flu pandemic of 1918 in modern world history. As of 7 September 2021, there have been 220 million confirmed cases of COVID-19 and more than 4.5 million deaths. …”
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Comparison of actions taken by Pakistan, United Arab Emirates and Vietnam for COVID-19 prevention and control
Published 2020-10-01“…This disease presents the worst public health crisis the world has faced since the Spanish flu pandemic in 1918. It is the biggest global public health challenge of our lifetimes. …”
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Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis
Published 2008“…This analysis identified 17 characteristic sites, five of which have been present in human-transmissible strains since the 1918 Spanish flu pandemic. Sixteen of these sites are located in functional domains, suggesting they may play functional roles in host-range specificity. …”
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Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis
Published 2007“…This analysis identified 17 characteristic sites, five of which have been present in human-transmissible strains since the 1918 Spanish flu pandemic. Sixteen of these sites are located in functional domains, suggesting they may play functional roles in host-range specificity. …”
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Centennial review of influenza in Taiwan
Published 2018-08-01“…The history of influenza in Taiwan can be traced up to the 1918 H1N1 Spanish flu pandemic, followed by several others including the 1957 H2N2, 1968 H3N2, and the 2009 new H1N1. …”
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Intensive care management of patients with COVID-19: a practical approach
Published 2021-02-01“…Abstract SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the early twentieth century. Since there is no specific antiviral treatment, optimized support is the most relevant factor in the patient's prognosis. …”
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Hyperbaric air mobilizes stem cells in humans; a new perspective on the hormetic dose curve
Published 2023-06-01“…HBA reached its zenith in the early 20th century when cyanotic, moribund “Spanish flu pandemic” patients turned normal color and regained consciousness within minutes after HBA treatment. …”
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Public Health and Epidemiological Considerations For Avian Influenza Risk Mapping and Risk Assessment
Published 2008-12-01“…Research has shown that the 1918 Spanish Flu pandemic was caused by an H1N1 influenza virus of avian origins, and during the past decade, fatal human disease and human-to-human transmission has been confirmed among persons infected with H5N1 and H7N7 avian influenza viruses. …”
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Covid-19 Dynamic Monitoring and Real-Time Spatio-Temporal Forecasting
Published 2021-04-01“…It has already been over a century post—the Spanish Flu pandemic, and we are witnessing a new type of coronavirus, the SARS-CoV-2, which is responsible for Covid-19. …”
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