Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series by Tarik Elhadd, Ahmad Majzoub, Charlotte Wilson, Laura McCreight, Muna S. Mohamed, Fiona C. Green, Andrew J. Collier

“…The third case was an XX male with unbalanced translocation between the X & Y chromosomes with retention of the SRY locus. Conclusion Hypergonadotrophic hypogonadism in the elderly, may be due to chromosomal aberrations, resulting in heterogeneous and diverse clinical phenotypes. …”
Get full text

Isolation and sequencing of the HMG domain of ten Sox genes from Odorrana schmackeri (Amphibia: Anura) by Ning Wang, Jing J. Wang, Rui Jia, Jin W. Xu, Liu W. Nie

“…Sox (SRY-related HMG-box) genes encode a family of transcriptional regulators, which are characterized by a conserved 79-amino acid domain known as HMG-box. …”
Get full text

SOX2 Promotes Invasion in Human Bladder Cancers through MMP2 Upregulation and FOXO1 Downregulation by Qipeng Xie, Xiaohui Hua, Chao Huang, Xin Liao, Zhongxian Tian, Jiheng Xu, Yunping Zhao, Guosong Jiang, Haishan Huang, Chuanshu Huang

“…SOX2, a member of the SRY-related HMG-box (SOX) family, is abnormally expressed in many tumors and associated with cancer stem cell-like properties. …”
Get full text

Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development by Khouloud Rjiba, Soumaya Mougou-Zerelli, Imen hadj Hamida, Ghada Saad, Bochra Khadija, Afef Jelloul, Wafa Slimani, Yosra Hasni, Sarra Dimassi, Hela Ben khelifa, Amira Sallem, Molka Kammoun, Hamza Hadj Abdallah, Moez Gribaa, Joelle Bignon-Topalovic, Sami Chelly, Hédi Khairi, Mohamed Bibi, Maha Kacem, Ali Saad, Anu Bashamboo, Kenneth McElreavey

“…Sanger sequencing of candidate genes identified a novel pathogenic variant in the SRY gene in a patient with 46,XY gonadal dysgenesis. …”
Get full text

Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples by Katharina Kriegsmann, Christa Flechtenmacher, Jörg Heil, Jörg Kriegsmann, Gunhild Mechtersheimer, Sebastian Aulmann, Wilko Weichert, Hans-Peter Sinn, Mark Kriegsmann

“…Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). …”
Get full text

DETERMINATION OF FETAL RHESUS D STATUS BY MATERNAL PLASMA DNA ANALYSIS by Aykut A., Onay H., Gunduz C., Ozkinay F., Cogulu O., Sagol S.

“…Exons 7 and 10 of the RHD and SRY genes were targeted. Among the pregnant women, 12 were carrying male and 17 were carrying female fetuses. …”
Get full text

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution by Taifeng Zhou, Yu Chen, Zhiheng Liao, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu, Peiqiang Su

“…They identify two novel human notochord (NC)/nucleus pulposus (NP) clusters, SRY‐box transcription factor 10 (SOX10)+ and cathepsin K (CTSK)+, that are distributed in the early and late stages of IVD formation and they are validated by lineage tracing experiments in mice. …”
Get full text

Molecular identification of archaic bones as a native Korean black bear: implications for the ongoing bear restoration program by Jee Yun Hyun, Tae-Wook Kim, Puneet Pandey, Kyung Seok Kim, Seung-Jun Jeong, Jae-Ku Kang, Dal-Yong Kong, Seung-Ho Jung, Ho-Kweon Jeong, Sang-Hoon Han, Sang-Hyun Han, Hang Lee

“…The genetic investigation (CytB, COI, D-loop, SRY, and ZFX-ZFY) identified the sample as a male Asian black bear with close phylogenetic affinity with Northeast Asian bears. …”
Get full text

Multi-Omics Analysis of <i>SOX4</i>, <i>SOX11</i>, and <i>SOX12</i> Expression and the Associated Pathways in Human Cancers by Jaekwon Seok, Minchan Gil, Ahmed Abdal Dayem, Subbroto Kumar Saha, Ssang-Goo Cho

“…The Sry-related HMG BOX (SOX) gene family encodes transcription factors containing highly conserved high-mobility group domains that bind to the minor groove in DNA. …”
Get full text

Molecular Characterization of a Male-Specific <i>SoxE</i> Gene in the Swimming Crab, <i>Portunus trituberculatus</i>, and Transcriptional Interaction with Insulin-like Androgenic G... by Qinghua Jiang, Dongjie Xu, Mengen Wang, Xi Xie, Dongfa Zhu

“…The <i>Sry</i>-related HMG-box (<i>Sox</i>) family is a group of transcriptional regulators that play a critical role in many important developmental processes in both vertebrates and invertebrates. …”
Get full text

The roles of Runx1 in skeletal development and osteoarthritis: A concise review by Yi Liu, Chengdong Huang, Mingru Bai, Caixia Pi, Demao Zhang, Jing Xie

“…Runx1 can regulate genes including collagen type II (Col2a1) and X (Col10a1), SRY-box transcription factor 9 (Sox9), aggrecan (Acan) and matrix metalloproteinase 13 (MMP-13), and the up-regulation of Runx1 improves the homeostasis of the whole joint, even in the pathological state. …”
Get full text

Detection of a 4 bp Mutation in the 3′UTR Region of Goat <i>Sox9</i> Gene and Its Effect on the Growth Traits by Libang He, Yi Bi, Ruolan Wang, Chuanying Pan, Hong Chen, Xianyong Lan, Lei Qu

“…The SRY-type HMG box 9 (<i>Sox9</i>) gene plays an important role in chondrocyte development as well as changes in hypertrophic chondrocytes, indicating that <i>Sox9</i> can regulate growth in animals. …”
Get full text

A Disorder of Sex Development in a Holstein–Friesian Heifer with a Rare Mosaicism (60,XX/90,XXY): A Genetic, Anatomical, and Histological Study by Izabela Szczerbal, Marcin Komosa, Joanna Nowacka-Woszuk, Tomasz Uzar, Marek Houszka, Jerzy Semrau, Magdalena Musial, Michal Barczykowski, Anna Lukomska, Marek Switonski

“…The molecular detection of Y-linked genes (<i>SRY</i> and <i>AMELY</i>) in the blood, skin, hair follicles, and buccal epithelial cells confirmed the presence of a cell line carrying the Y chromosome. …”
Get full text

Enrichment of SOX2-Positive Cells in BRAF V600E Mutated and Recurrent Ameloblastoma by Chih-Huang Tseng, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu Fong Chang

“…Elucidation of the cellular and molecular mechanisms underlying the tumor stem cells is of broad interest for understanding tumorigenesis and for developing effective targeted therapies. SRY related HMG box gene 2 (SOX2) is a transcription factor that plays important roles in development, stem cell renewal, and cancer formation. …”
Get full text

SOX11 and Epithelial-Mesenchymal Transition in Metastatic Serous Ovarian Cancer by Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou

“…Epithelial–mesenchymal transition (EMT) correlates with increased metastatic potential, whereas the transcription factor SRY-box transcription factor 11 (SOX11) is overexpressed in diverse malignancies. …”
Get full text

Gut microbiota variations in wild yellow baboons (Papio cynocephalus) are associated with sex and habitat disturbance by Marina Bambi, Giulio Galla, Claudio Donati, Francesco Rovero, Heidi C. Hauffe, Claudia Barelli

“…Sex determination was performed using the marker genes SRY (Sex-determining Region Y) and DDX3X-DDX3Y (DEAD-Box Helicase 3). …”
Get full text

Phylogenetic analysis reveals multiple origins of Chinese gamecocks by Xufang Ren, Zi Guan, Haiying Li, Li Zhang, Junhui Wen, Xiurong Zhao, Gang Wang, Xinye Zhang, Huie Wang, Fuqing Yu, Zhihua Chen, Lujiang Qu

“…Therefore, this study used next-generation resequencing data to elucidate the origin of Chinese gamecocks by constructing genome-wide and SRY-box transcription factor 5 (SOX5) gene phylogenetic trees. …”
Get full text

Role of SOX9 and Hif-1α expression in placentas of patients with HELLP by Senem Alkan Akalın, Ece Öcal, Engin Deveci

“…ABSTRACT Purpose: In this study, we investigated the immunohistochemical staining of SRY-box transcription factor 9 (SOX9) and Hif-1α expression in placentas of pregnant woman with hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. …”
Get full text

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements by Prabhakar, Shyam, Jauch, Ralf, Ng, Calista K. L., Li, Noel X., Chee, Sheena., Kolatkar, Prasanna R.

“…Sox2, Sox14, Sox21 and Sox15 strongly cooperate on the canonical element but compete with Oct4 on a recently discovered compressed element. Sry also cooperates on the canonical element but binds additively to the compressed element. …”
Get full text
Get full text

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity by Chng, Song Hui, Kundu, Parag, Dominguez-Brauer, Carmen, Teo, Wei Ling, Mak, Tak Wah, Pettersson, Sven, Kawajiri, Kaname, Fujii-Kuriyama, Yoshiaki

“…Moreover, when co-cultured with AhR-deficient DCs ex vivo, intestinal organoids showed reduced SRY (sex determining region Y)-box 9 and increased Mucin 2 expression, which correlates with reduced Paneth cells and increased goblet cell differentiation, similar to the data obtained in vivo. …”
Get full text
Get full text