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  1. 30701

    Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling by Wittmann, Dominik M., Krumsiek, Jan, Saez-Rodriguez, Julio, Lauffenburger, Douglas A., Klamt, Steffen, Theis, Fabian J.

    Published 2010
    “…Results In this contribution we present a canonical way of transforming Boolean into continuous models, where the use of multivariate polynomial interpolation allows transformation of logic operations into a system of ordinary differential equations (ODE). The method is standardized and can readily be applied to large networks. …”
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