Characteristics and in-hospital mortality of patients with COVID-19 from the first to fifth waves of the pandemic in 2020 and 2021 in the Japanese Medical Data Vision database by Suzuki, T, Taniguchi, Y, Komiyama, J, Kuno, T, Adomi, M, Abe, T, Inokuchi, R, Miyawaki, A, Imai, S, Saito, M, Ohbe, H, Aso, S, Kamio, T, Tamiya, N, Iwagami, M

“…<br><strong>Results<br></strong> From the first to fifth waves, the number of patients (mean age ± standard deviation, years) was 2958 (61.2 ± 22.8), 7981 (55.6 ± 25.3), 18,788 (63.6 ± 22.9), 17,729 (60.6 ± 22.6), and 23,656 (51.2 ± 22.3), respectively. …”

Integrated management systems (IMS) to support and sustain quality one health services: international lessons from the COVID-19 pandemic by the IMIA primary care working group by Jonnagaddala, J, Hoang, U, Wensaas, K-A, Tu, K, Ortigoza, A, Silva-Valencia, J, Cuba-Fuentes, MS, Godinho, MA, de Lusignan, S, Liaw, S-T

“…However, IMS use was pragmatic rather than utilising an international standard, with some of their benefits lost post-pandemic. …”

Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin... by Tousoulis, D, Antoniades, C, Marinou, K, Vasiliadou, C, Bouras, G, Stefanadi, E, Latsios, G, Siasos, G, Toutouzas, K, Stefanadis, C

“…METHODS: In this double-blind placebo controlled study, 28 subjects of both genders (14 with homocysteinemia and 14 healthy controls) underwent methionine-loading (100mg/Kg body weight) in a standard juice, containing vitamins C (2g) plus E (800IU) (n = 14) or no vitamins (placebo group, n = 14). …”

Endocardial left ventricular pacing across the interventricular septum for cardiac resynchronization therapy: clinical results of a pilot study by Gamble, JHP, Herring, N, Ginks, MR, Rajappan, K, Bashir, Y, Betts, TR

“…</p> <p>Conclusion</p> <p>LV endocardial pacing via interventricular septal puncture in patients for whom standard CRT is not possible is similarly effective and durable, with significant but potentially acceptable risks.…”

Comparison between non‐orographic gravity‐wave parameterizations used in QBOi models and Strateole 2 constant‐level balloons by Lott, F, Rani, R, McLandress, C, Podglajen, A, Bushell, A, Bramberger, M, Lee, H, Alexander, J, Anstey, J, Chun, H, Hertzog, A, Butchart, N, Kim, Y, Kawatani, Y, Legras, B, Manzini, E, Naoe, H, Osprey, S, Plougonven, R, Pohlmann, H, Richter, JH, Scinocca, J, García‐Serrano, J, Serva, F

“…The parameterizations employ the three standard techniques used in GCMs to represent subgrid‐scale non‐orographic GWs, namely the two globally spectral techniques developed by Warner and McIntyre (1999) and Hines (1997), as well as the “multiwaves” approaches following the work of Lindzen (1981). …”

A behavioural test to assess daytime sleepiness in obstructive sleep apnoea. by Bennett, L, Stradling, J, Davies, R

“…Daytime sleepiness is an important symptom of obstructive sleep apnoea syndrome (OSAS). The standard tests for its objective quantification use EEG recordings, and are time consuming and expensive, which makes them difficult to use for large studies. …”

PhenoMeNal: processing and analysis of metabolomics data in the cloud by Peters, K, Bradbury, J, Bergmann, S, Capuccini, M, Cascante, M, De Atauri, P, Ebbels, T, Foguet, C, Glen, R, Gonzalez-Beltran, A, Guenther, U, Handakas, E, Hankemeier, T, Herman, S, Haug, K, Holub, P, Izzo, M, Jacob, D, Johnson, D, Jourdan, F, Kale, N, Karaman, I, Khalili, B, Khoonsari, P, Kultima, K, Lampa, S, Larsson, A, Ludwig, C, Moreno, P, Neumann, S, Novella, JA, O'Donovan, C, Pearce, JTM, Peluso, A, Pireddu, L, Piras, ME, Reed, MAC, Rocca-Serra, P, Roger, P, Rosato, A, Rueedi, R, Ruttkies, C, Sadawi, N, Salek, R, Sansone, S-A, Selivanov, V, Spjuth, O, Schober, D, Thévenot, E, Tomasoni, M, Van Rijswijk, M, Van Vliet, M, Viant, M, Weber, R, Zanetti, G, Steinbeck, C

“…It also provides a number of standardized, automated and published analysis workflows in the user interfaces Galaxy, Jupyter, Luigi and Pachyderm. …”

Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use by Shrestha, P, Cooper, B, Coast, J, Oppong, R, Do, N, Pudha, T, Guerin, P, Wertheim, H, Lubell, Y

“…The cost of AMR associated with the consumption of one standard unit (SU) of antibiotics ranged from $0.1 for macrolides to $0.7 for quinolones, cephalosporins and broad-spectrum penicillins in the Thai context. …”

A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination by Ausimmune Investigator Group, Black, LJ, Rowley, C, Sherriff, J, Pereira, G, Ponsonby, A-L, Lucas, RM

“…</p> <p><strong>Results:</strong></p> <p>We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). …”

Risk factors for stroke, myocardial infarction, or death following carotid endarterectomy: results from the international carotid stenting study by Doig, D, Turner, E, Dobson, J, Featherstone, R, De Borst, G, Stansby, G, Beard, J, Engelter, S, Richards, T, Brown, M

“… <p style="text-align:justify;"><b>Objectives:</b> Carotid endarterectomy (CEA) is standard treatment for symptomatic carotid artery stenosis but carries a risk of stroke, myocardial infarction (MI), or death. …”

Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future by Hermans, TJN, Voskuilen, CS, Van Der Heijden, MS, Schmitz-Dräger, BJ, Kassouf, W, Seiler, R, Kamat, AM, Grivas, P, Kiltie, AE, Black, PC, Van Rhijn, BWG

“…Based on level I evidence, cisplatin-based NAC (CB-NAC) is considered standard of care in cT2–4aN0M0 MIBC. NAC results in a 6% absolute 10-year overall survival (OS) benefit. …”

Integrating clinical features with genetic factors enhances survival prediction for adults with acute myeloid leukemia by Silveira, DRA, Quek, L, Santos, IS, Corby, A, Coelho-Silva, JL, Pereira-Martins, DA, Vallance, G, Brown, B, Nardinelli, L, Silva, WF, Velloso, EDRP, Lucena-Araujo, AR, Traina, F, Peniket, A, Vyas, P, Rego, EM, Bendit, I, Rocha, V

“…We first analyzed 167 intensively treated patients with nonacute promyelocytic leukemia AML enrolled in São Paulo, Brazil (Faculdade de Medicina da Universidade de São Paulo), as our training data set, using ELN2017 as the standard for comparison with our AGR. Next, we combined our AGR with clinical prognostic parameters found in a Cox proportional hazards model to create a novel scoring system (survival AML score, SAMLS) that stratifies patients with newly diagnosed AML. …”

Spread of Yellow Fever Virus outbreak in Angola and the Democratic Republic Congo 2015-2016: a modelling study by Kraemer, M, Faria, N, Reiner, R, Golding, N, Nikolay, B, Stasse, S, Johansson, M, Salje, H, Faye, O, Wint, G, Niedrig, M, Shearer, F, Hill, S, Thompson, R, Bisanzio, D, Taveira, N, Nax, H, Pradelski, B, Nsoesie, E, Murphy, N, Bogoch, I, Khan, K, Brownstein, J, Tatem, A, de Oliveira, T, Smith, D, Sall, A, Pybus, O, Hay, S, Cauchemez, S

“…<br/>Methods: We jointly analysed datasets describing the epidemic of YFV, vector suitability, human demography and mobility in Central Africa in order to understand and predict the expansion of YFV. We used a standard logistic model to infer the district YFV infection risk over the course of the epidemic in the region. …”

An evidence-based evaluation of systematic conservation planning by McIntosh, EJ

“…Following this I catalogued the literature on systematic conservation planning from across 29 academic and non-academic sources, using a gold standard evidence synthesis method, systematic mapping. …”

Immunotherapy-related hepatitis: real-world experience from a tertiary centre by Cheung, V, Gupta, T, Payne, M, Middleton, MR, Collier, JD, Simmons, A, Klenerman, P, Brain, O, Cobbold, JF

“…<p><strong>Objective</strong> Immune checkpoint inhibitors like anti-programmed cell death protein 1 (PD-1) drugs Nivolumab and Pembrolizumab and anti-cytotoxic T-lymphocyte associated (CTLA-4) drug Ipilimumab have become standard of care in many metastatic cancers. Immunotherapy-related hepatitis and cholangitis present a diagnostic and management challenge, being rare and incompletely characterised. …”

Synthesizing nested relational queries from implicit specifications: via model theory and via proof theory by Benedikt, M, Pradic, C, Wernhard, C

“…We first provide a model-theoretic argument for this result, which makes some additional connections that may be of independent interest, between NRC queries, interpretations, a standard mechanism for defining structure-to-structure translation in logic, and between interpretations and implicit to definability “up to unique isomorphism”. …”

The spectrum of cardiac abnormalities in patients with acromegaly: results from a case-control cardiac magnetic resonance study by De Alcubierre, D, Feola, T, Cozzolino, A, Pofi, R, Galea, N, Catalano, C, Auriemma, RS, Pirchio, R, Pivonello, R, Isidori, AM, Giannetta, E

“…Cardiac magnetic resonance (CMR) is the gold standard for measuring cardiac morpho-functional changes. …”

Accuracy of heart failure ascertainment using routinely collected healthcare data: a systematic review and meta-analysis by Goonasekera, MA, Offer, A, Karsan, W, El-Nayir, M, Mallorie, AE, Parish, S, Haynes, RJ, Mafham, MM

“…We systematically reviewed studies assessing RCD-based HF outcome ascertainment against “gold standard” (GS) methods to study the feasibility of using such methods in clinical trials. …”

Defining wisdom : Ratnākaraśānti's Sāratamā by Seton, G

“…The second part consists of an annotated translation of the <em>Sāratamā</em>’s introductory section, contrasted with the prior standard interpretation by Haribhadra’s (9th century C.E.). …”

Modelling solar-like variability for the detection of Earth-like planetary transits II. Performance of the three-spot modelling, harmonic function fitting, iterative nonlinear filt... by Bonomo, A, Aigrain, S, Borde, P, Lanza, A

“…We apply a Monte Carlo approach by simulating a large number of 150-day light curves (as for CoRoT long runs) for different planetary radii, orbital periods, epochs of the first transit, and standard deviations of the photon shot noise. Stellar variability is given by the total solar irradiance variations as observed close to the maximum of solar cycle 23. …”