Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques by Linda Cerofolini, Marco Fragai, Enrico Ravera, Christoph A. Diebolder, Ludovic Renault, Vito Calderone

Subjects: “…integrative structural biology…”
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STRUCTURAL BIOLOGY OF THE INTRINSIC CELL DEATH PATHWAY: WHAT DO WE KNOW AND WHAT IS MISSING? by Walter Douglas Fairlie, Erinna Faith Lee

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Ten simple rules to create a serious game, illustrated with examples from structural biology. by Marc Baaden, Olivier Delalande, Nicolas Ferey, Samuela Pasquali, Jérôme Waldispühl, Antoine Taly

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Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists by Lei Sun, Zhi-Ming Zheng, Chang-Sheng Shao, Zhi-Yong Zhang, Ming-Wei Li, Li Wang, Han Wang, Gen-Hai Zhao, Peng Wang

“…This study provides important drug design ideas for GLP-1RA development and a new example for application of structural biology-based protein design in drug development.…”
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Scipion3: A workflow engine for cryo-electron microscopy image processing and structural biology by Pablo Conesa, Yunior C. Fonseca, Jorge Jiménez de la Morena, Grigory Sharov, Jose Miguel de la Rosa-Trevín, Ana Cuervo, Alberto García Mena, Borja Rodríguez de Francisco, Daniel del Hoyo, David Herreros, Daniel Marchan, David Strelak, Estrella Fernández-Giménez, Erney Ramírez-Aportela, Federico Pedro de Isidro-Gómez, Irene Sánchez, James Krieger, José Luis Vilas, Laura del Cano, Marcos Gragera, Mikel Iceta, Marta Martínez, Patricia Losana, Roberto Melero, Roberto Marabini, José María Carazo, Carlos Oscar Sánchez Sorzano

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Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview by Francesca Paoletti, Doriano Lamba

“…We recently unveiled, by an integrated structural biology approach, the ATP binding sites of NGF and investigated the effects on TrkA and p75^NTR receptors binding. …”
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Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology by Adam C. Oken, Ipsita Krishnamurthy, Jonathan C. Savage, Nicolas E. Lisi, Michael H. Godsey, Steven E. Mansoor, Steven E. Mansoor

“…The therapeutic potential of P2XRs is an emerging area of research in which structural biology has seemingly exceeded medicinal chemistry, as there are several published P2XR structures but currently no FDA-approved drugs targeting these ion channels. …”
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Current limits of structural biology: The transient interaction between cytochrome c6 and photosystem I by A. Kölsch, C. Radon, M. Golub, A. Baumert, J. Bürger, T. Mielke, F. Lisdat, A. Feoktystov, J. Pieper, A. Zouni, P. Wendler

“…Current Research in Structural Biology…”
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Computational strategies and challenges for using native ion mobility mass spectrometry in biophysics and structural biology by Allison, TM, Barran, P, Cianférani, S, Degiacomi, MT, Gabelica, V, Grandori, R, Marklund, EG, Menneteau, t, Migas, LG, Politis, A, Sharon, M, Sobott, F, Thalassinos, K, Benesch, JLP

“…Our perspective is based on discussions within the European Cooperation in Science and Technology Action on Native Mass Spectrometry and Related Methods for Structural Biology (EU COST Action BM1403), which involved participants from across Europe and North America. …”

Chemical structures, biological activities, and medicinal potentials of amine compounds detected from Aloe species by Adamu Tizazu Yadeta

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RNA Methylations in Cardiovascular Diseases, Molecular Structure, Biological Functions and Regulatory Roles in Cardiovascular Diseases by Wanwan Zhou, Changhui Wang, Jun Chang, Yurong Huang, Qiuyun Xue, Chenggui Miao, Chenggui Miao, Peng Wu

“…In view of the importance of RNA methylations in the pathogenesis of diseases, this work reviews the molecular structures, biological functions of five kinds of RNA methylations (m6A, m5C, m1a, m6am and m7G) and their effects on CVDs, including pulmonary hypertension, hypertension, vascular calcification, cardiac hypertrophy, heart failure. …”
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Bioactive secondary metabolites produced by fungi of the genus Diaporthe (Phomopsis): Structures, biological activities, and biosynthesis by Lin Jiang, Qingxian Ma, Aijie Li, Runze Sun, Genyun Tang, Xueshuang Huang, Hong Pu

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Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry by Krishna M. Padmanabha Das, Krishna M. Padmanabha Das, William M. Shih, William M. Shih, Gerhard Wagner, Mahmoud L. Nasr

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Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology by Xiusheng Zhu, Qitong Huang, Jing Luo, Dashuai Kong, Yubo Zhang

“…In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. …”
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The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design by Carlos P. Modenutti, Carlos P. Modenutti, Juan I. Blanco Capurro, Juan I. Blanco Capurro, Santiago Di Lella, Santiago Di Lella, Marcelo A. Martí, Marcelo A. Martí

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Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach by Polina V. Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval

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New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility by Robbins Puthenveetil, Eric T. Christenson, Olga Vinogradova

“…Since the advent of various structural biology techniques, a sub-population of these proteins has become accessible to investigation at near-atomic resolutions. …”
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Editorial: Aptamer-based structural biology, computational modelling, translational research and drug discovery, Volume II by Yuan Ma, Yuan Ma, Yuanyuan Yu, Yuanyuan Yu, Baoting Zhang, Aiping Lu, Aiping Lu, Ge Zhang, Ge Zhang

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Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I by Kimberly T. Lane, Lorena S. Beese

“…In this review, we examine the structural biology of FTase and GGTase-I (the CaaX prenyltransferases) to establish a framework for understanding the molecular basis of substrate specificity and mechanism. …”
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Novel Natural Inhibitors Targeting Enhancer of Zeste Homolog 2: A Comprehensive Structural Biology Research by Weihang Li, Ziyi Ding, Yunlong Zhao, Min Jiang, Shilei Zhang, Hongzhe Zhao, Ke Lei, Rui Xu, Yingjing Zhao, Dong Wang, Min Chao, Yanjiang Yin, Changbin Yang, Liang Wang, Ming Yan

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