ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration di Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi, Koji Yamanaka

Soggetti: Testo

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis di Yuting Ren, Yuting Ren, Siyuan Li, Siyu Chen, Xiaosun Sun, Xiaosun Sun, Fei Yang, Hongfen Wang, Mao Li, Fang Cui, Xusheng Huang

Soggetti: Testo

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43 di Juan M. Godoy-Corchuelo, Zeinab Ali, Jose M. Brito Armas, Aurea B. Martins-Bach, Irene García-Toledo, Luis C. Fernández-Beltrán, Juan I. López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A. Muñoz de Bustillo Alfaro, Maria J. Sánchez-Barrena, Remya R. Nair, Brian J. Nieman, Jason P. Lerch, Karla L. Miller, Hande P. Ozdinler, Elizabeth M.C. Fisher, Thomas J. Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano

Soggetti: “...TDP-43...”
Testo

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo di Charlton G. Otte, Tyler R. Fortuna, Jacob R. Mann, Amanda M. Gleixner, Nandini Ramesh, Noah J. Pyles, Udai B. Pandey, Christopher J. Donnelly

Soggetti: “...TDP-43...”
Testo

TDP-43 Pathology in Alzheimer’s Disease di Axel Meneses, Shunsuke Koga, Justin O’Leary, Dennis W. Dickson, Guojun Bu, Na Zhao

Soggetti: Testo

The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis di Caterina Maria Gambino, Anna Maria Ciaccio, Bruna Lo Sasso, Rosaria Vincenza Giglio, Matteo Vidali, Luisa Agnello, Marcello Ciaccio

Soggetti: “...TDP-43...”
Testo

Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study di Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M. Boeckers, Jakob Matschke, Christian Mawrin, Albert C. Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braak

Soggetti: Testo

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells di Rudolf Hergesheimer, Débora Lanznaster, Jérôme Bourgeais, Olivier Hérault, Patrick Vourc’h, Christian R. Andres, Philippe Corcia, Hélène Blasco

Soggetti: “...TDP-43...”
Testo

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy di Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen

Soggetti: “...TDP-43...”
Testo

Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases di Chunhui Huang, Sen Yan, Zaijun Zhang

Soggetti: “...TDP-43...”
Testo

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD di Tanzeen Yusuff, Tanzeen Yusuff, Ya-Chu Chang, Ya-Chu Chang, Tzu-Kang Sang, Tzu-Kang Sang, George R. Jackson, George R. Jackson, George R. Jackson, George R. Jackson, George R. Jackson, Shreyasi Chatterjee, Shreyasi Chatterjee, Shreyasi Chatterjee

Soggetti: Testo

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation di Nikita Fernandes, Luke Nero, Shawn M. Lyons, Pavel Ivanov, Telsa M. Mittelmeier, Timothy A. Bolger, J. Ross Buchan

Soggetti: “...TDP-43...”
Testo

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis di Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman

Soggetti: Testo

Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1 di Katrin Hipke, Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Miha Modic, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Dieter Edbauer, Dieter Edbauer, Stefan Bonn, Christian Haass, Christian Haass, Christian Haass, Ulrich Pohl, Ulrich Pohl, Ulrich Pohl, Ulrich Pohl, Eloi Montanez, Bettina Schmid, Bettina Schmid

Soggetti: “...TDP-43...”
Testo

Effect of icaritin on autophagy-related protein expression in TDP-43-transfected SH-SY5Y cells di Yanjun Zhou, Nanqu Huang, Yuanyuan Li, Zhisheng Ba, Yong Luo

Soggetti: “...TDP-43...”
Testo

Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD di Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer

Soggetti: Testo

Mechanisms of Neurosyphilis-Induced Dementia: Insights into Pathophysiology di Aya Fadel, Hussain Hussain, Robert J. Hernandez, Amanda Marie Clichy Silva, Amir Agustin Estil-las, Mohammad Hamad, Zahraa F. Saadoon, Lamia Naseer, William C. Sultan, Carla Sultan, Taylor Schnepp, Arumugam R. Jayakumar

Soggetti: Testo

Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations di Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant

Soggetti: Testo

Novel in vivo TDP-43 stress reporter models to accelerate drug development in ALS di Febe Ferro, C. Roland Wolf, Christopher Henstridge, Francisco Inesta-Vaquera

Soggetti: Testo

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons di Daiyu Honda, Shinsuke Ishigaki, Yohei Iguchi, Yusuke Fujioka, Tsuyoshi Udagawa, Akio Masuda, Kinji Ohno, Masahisa Katsuno, Gen Sobue

Soggetti: Testo