Identification of m6A methylation-related genes in cerebral ischaemia‒reperfusion of Breviscapus therapy based on bioinformatics methods by Cheng Wan, Jingchun Pei, Dan Wang, Jihong Hu, Zhiwei Tang, Wei Zhao

“…IPA revealed that Tfcp2l1 played a significant role in human embryonic stem cell pluripotency. …”
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An Integrative ATAC-Seq and RNA-Seq Analysis of the Endometrial Tissues of Meishan and Duroc Pigs by Han Zhang, Zhexi Liu, Ji Wang, Tong Zeng, Xiaohua Ai, Keliang Wu

“…Interestingly, <i>ANXA4</i>, <i>CBFA2T2</i>, and <i>TFCP2L1</i>, which were upregulated in the Meishan pigs in the RNA-seq analysis, were identified again by the integration of the ATAC-seq and RNA-seq data. …”
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CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth by J. Yang, K. Bergdorf, C. Yan, W. Luo, S. C. Chen, G.D. Ayers, Q. Liu, X. Liu, M. Boothby, V.L. Weiss, S. M. Groves, A. N. Oleskie, X. Zhang, D. Y. Maeda, J. A. Zebala, V. Quaranta, A. Richmond

“…Interestingly, after Cxcr2 ablation, Tfcp2l1, a key tumor suppressive transcription factor, was the only gene significantly induced with a log2 fold-change greater than 2 in these three different melanoma models. …”
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Predictive value of DNA methylation in the efficacy of chemotherapy for gastric cancer by Ye Li, Ning Mo, Dong Yang, Dong Yang, QiuLu Lin, WenFeng Huang, Rensheng Wang

“…Six genes were optimally chosed for establisehing the risk model, including C6orf222, CCNL1, CREBZF, GCKR, TFCP2, and VIPR2. It was constructed based on the DNA methylation levels of these six genes: risk score = 0.47123374*C6orf222 + 9.53554803*CCNL1 + 10.40234138* CREBZF + 0.07611856* GCKR + 18.87661557*TFCP2 − 0.46396254* VIPR2. …”
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Update of Key Clinical, Histological and Molecular Features of Malignant Bone Tumours Arising in the Craniofacial Skeleton by Simon Haefliger, Vanghelita Andrei, Daniel Baumhoer

“…Examples include HEY1-NCOA2 in mesenchymal chondrosarcoma, IDH1/2 mutations in chondrosarcoma and TFCP2 rearrangements in rhabdomyosarcoma. In this article, key clinical, histological and molecular features of malignant bone tumours arising in the craniofacial region are discussed, with a special focus on the differential diagnosis and prognostic considerations.…”
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Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules by Patrick Stoiber, Pietro Scribani Rossi, Niranjana Pokharel, Jean-Luc Germany, Emily A. York, Scott E. Schaus, Ulla Hansen

“…Abstract Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2). These compounds exert anti-proliferative activity at least in part by disrupting mitotic spindles. …”
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Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation by Yan Bi, Zhifen Tu, Yanping Zhang, Peng Yang, Mingyue Guo, Xuehao Zhu, Chengchen Zhao, Jianfeng Zhou, Hong Wang, Yixuan Wang, Shaorong Gao

“…Moreover, we show that ALPPL2 can interact with the RNA-binding protein IGF2BP1 to stabilize the mRNA levels of the naive pluripotency transcription factors TFCP2L1 and STAT3 to regulate naive pluripotency. …”
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NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation by Labhart Paul, Brynczka Christopher, Merrick B Alex

“…The most salient differentiation-relevant target genes included <it>wnt7b </it>involved in dendritic extension and the <it>tfcp2l4/grhl3 </it>grainyhead homolog implicated in ectodermal development. …”
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What Would Next Generation Sequencing Bring to the Diagnosis and Treatment of Sarcomas? A Series of 20 Cases, a Single Institution's Experience by İbrahim KULAÇ, Pınar BULUTAY, Çisel AYDIN MERİÇÖZ

“…NGS results drastically changed the initial diagnosis, and thus the treatment modalities, in 3 cases (15%): the case with ETV6-NTRK3 fusion, the case with FUS-TFCP2 fusion, and the case of rhabdomyosarcoma (RMS) that was favored to be of the alveolar subtype and turned out to lack FOXO1 fusions. …”
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Gene expression profile of the cartilage tissue spontaneously regenerated <it>in vivo </it>by using a novel double-network gel: Comparisons with the normal articular cartilage by Kurokawa Takayuki, Kitamura Nobuto, Onodera Shin, Joon Kwon Hyuck, Ohmiya Yoshihiro, Imabuchi Ryusei, Ping Gong Jian, Yasuda Kazunori

“…The top 30 genes that expressed 5 times or more in the regenerated tissue as compared with the normal cartilage included type-2 collagen, type-10 collagen, FN, vimentin, COMP, EF1alpha, TFCP2, and GAPDH genes.</p> <p>Conclusions</p> <p>The tissue regenerated by using the DN gel was genetically similar but not completely identical to articular cartilage. …”
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The expression of stem cells markers and its effects on the propensity for recurrence and metastasis in bladder cancer: A systematic review. by Agus Rizal Ardy Hariandy Hamid, Yasmina Zahra Syadza, Oliver Emmanuel Yausep, Roberto Bagaskara Indy Christanto, Bayu Hernawan Rahmat Muharia, Chaidir Arif Mochtar

“…SOX2, IGF1R, SOX4, ALDH1, CD44, Cripto-1, OCT4, ARRB1, ARRB2, p-TFCP2L1, CDK1, DCLK1, and NANOG, which were all identified as CSC markers. …”
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Bioinformatic characterization of differential proteins in the hippocampus of Ts65Dn: A mouse model of down syndrome by Zhang Bin, Kong Jing, Ye Shi, Wang Qiu-Wei, Shao Hi-He S., Yu Bin

“…Using PAJEK, a network of protein interactions was constructed and the top ten hub proteins were FYN, YBX1, VIM, PRKACA, EWSR1, H2AFX, CACNA1A, PTN, TFCP2L1 and CRKL. Through preliminarily discovered differentially expressed proteins by iTRAQ and bioinformatics analysis, we concluded that these proteins could be closely related to the neurological deficits of DS.…”
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New miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney. by Apostolos Zaravinos, George I Lambrou, Nikos Mourmouras, Patroklos Katafygiotis, Gregory Papagregoriou, Krinio Giannikou, Dimitris Delakas, Constantinos Deltas

“…The AB8/13 undifferentiated podocyte cells were used for functional assays using luciferase reporter constructs and the developmental transcription factor TFCP2L1 was proved to be a true target of miR-489, which was the second most upregulated miRNA in ccRCC. …”
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Screening of Transcription Factors Involved in Fetal Hemoglobin Regulation Using Phylogenetic Footprinting by Gisele Cristine De Souza Carrocini, Larissa Paola Rodrigues Venancio, Claudia Regina Bonini-Domingos

“…Of these motifs, 13 showed relation to Hb F regulation: cell division cycle-5 (CDC5), myeloblastosis viral oncogene homolog (c-MYB), transcription factor CP2 (TFCP2), GATA binding protein 1 (GATA-1), GATA binding protein 2 (GATA-2), nuclear factor erythroid 2 (NF-E2), nuclear transcription factor Y (NF-Y), runt-related transcription factor 1 (RUNX-1), T-cell acute lymphocytic leukemia 1 (TAL-1), YY1 transcription factor (YY1), beta protein 1 (BP1), chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), and paired box 1 (PAX-1). …”
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Pathway signature and cellular differentiation in clear cell renal cell carcinoma. by Han W Tun, Laura A Marlow, Christina A von Roemeling, Simon J Cooper, Pamela Kreinest, Kevin Wu, Bruce A Luxon, Mala Sinha, Panos Z Anastasiadis, John A Copland

“…We revealed significant down-regulation of four developmental transcription factors (GATA3, TFCP2L1, TFAP2B, DMRT2) that are important for normal renal development.ccRCC is characterized by a lack of epithelial differentiation, mesenchymal/adipogenic transdifferentiation, and pluripotent mesenchymal stem cell-like differentiation capacity in vitro. …”
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A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host by Qurat ul Ain Farooq, Zeeshan Shaukat, Sara Aiman, Tong Zhou, Chunhua Li

“…Among human proteins, LNX2, MEOX2, TFCP2, PRKRA and DVL2 have the most interactions with viral proteins. …”
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Structural and Functional Insights into CP2c Transcription Factor Complexes by Seung Han Son, Min Young Kim, Eunbi Jo, Vladimir N. Uversky, Chul Geun Kim

“…CP2c, also known as TFCP2, α-CP2, LSF, and LBP-1c, is a prototypic member of the transcription factor (TF) CP2 subfamily involved in diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies including cancer. …”
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Analysis of Key Genes and miRNA-mRNA Networks Associated with Glucocorticoids Treatment in Chronic Obstructive Pulmonary Disease by Wu JJ, Zhang PA, Chen MZ, Zhang Y, Du WS, Li XN, Ji GC, Jiang LD, Jiao Y, Li X

“….; ③ CD2, SLAMF7, etc. may be the key targets of GC in the treatment of COPD; ④ 18 intersection genes were predicted by the mirwalk 3.0 database, and 9 pairs of miRNA-mRNA regulatory networks were identified; ⑤ The expression of miR-320d-2 and TFCP2L1 were upregulated by dexamethasone in the COPD cell model, while the expression of miR-181a-2-3p and SLAMF7 were downregulated.Conclusion: In COPD, GC may mediate the expression of the PI3K/Akt signalling pathway through miR-181a-2-3p, miR-320d-2, miR-650, and miR-155-5p, targeting its downstream signal factors. …”
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Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells by Mahmoud M. Mostafa, Christopher F. Rider, Suharsh Shah, Suzanne L. Traves, Paul M. K. Gordon, Anna Miller-Larsson, Richard Leigh, Robert Newton

“…Using the above criteria, 17 (BCL6, BIRC3, CEBPD, ERRFI1, FBXL16, FKBP5, GADD45B, IRS2, KLF9, PDK4, PER1, RGCC, RGS2, SEC14L2, SLC16A12, TFCP2L1, TSC22D3) induced and 8 (ARL4C, FLRT2, IER3, IL11, PLAUR, SEMA3A, SLC4A7, SOX9) repressed mRNAs were common between A549, BEAS-2B and HBE cells at 6 h. …”
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Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits by Roubi Abuobeid, Javier Sánchez-Marco, María J. Felices, Carmen Arnal, Juan Carlos Burillo, Roberto Lasheras, Rebeca Busto, Miguel A. Lasunción, María Jesús Rodríguez-Yoldi, Roberto Martínez-Beamonte, Jesús Osada

“…When the results were confirmed by RT-qPCR, rabbits receiving squalene displayed significant hepatic expression changes of <i>LOC100344884</i> (<i>PNPLA3</i>), <i>GCK</i>, <i>TFCP2L1</i>, <i>ASCL1</i>, <i>ACSS2</i>, <i>OST4</i>, <i>FAM91A1</i>, <i>MYH6</i>, <i>LRRC39</i>, <i>LOC108176846</i>, <i>GLT1D1</i> and <i>TREH</i>. …”
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