A novel panel of clinically relevant miRNAs signature accurately differentiates oral cancer from normal mucosa by Nikolay Mehterov, Nikolay Mehterov, Andrea Sacconi, Claudio Pulito, Boyan Vladimirov, Georgi Haralanov, Dimitar Pazardjikliev, Boyan Nonchev, Ioana Berindan-Neagoe, Giovanni Blandino, Victoria Sarafian, Victoria Sarafian

“…A set of 10 miRNAs were selected via an in silico approach by analysing the 3’untranslated regions (3’UTRs) of cancer-related mRNAs such as FLRT2, NTRK3, and SLC8A1, TFCP2L1 and etc. RT-qPCR was used to compare the expression of in silico identified miRNAs in OSCC and normal tissues (n=32).ResultsAmong the screened miRNAs, miR-21-5p (p < 0.0001), miR-93-5p (p < 0.0197), miR-146b-5p (p <0.0012), miR-155-5p (p < 0.0001), miR-182-5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354). …”
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