Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions by Julia Schöpf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav D. Diwan, Zunamys I. Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Dominic Helm, Martin Schneider, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert B. Russell, Barbara C. Jones, Daniel B. Lipka, Hanno Glimm, Daniel Hübschmann, Wolfgang Hartmann, Stefan Fröhling, Claudia Scholl

“…We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. …”
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TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy by Xiao Zhang, Fenyong Sun, Yongxia Qiao, Weisheng Zheng, Ya Liu, Yan Chen, Qi Wu, Xiangfan Liu, Guoqing Zhu, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang

“…Mechanistically, YAP function is stimulated by TFCP2 via a WW-PSY interaction. TFCP2 also maintains YAP stability by inhibiting βTrCP. …”
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Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression by D. Otero-Albiol, J. M. Santos-Pereira, A. Lucena-Cacace, C. Clemente-González, S. Muñoz-Galvan, Y. Yoshida, A. Carnero

“…Tfcp2l1 expression is lost during culture in normoxia, and its expression in hypoxia is regulated by Hif1α. …”
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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts by Max Werth, Kai M Schmidt-Ott, Thomas Leete, Andong Qiu, Christian Hinze, Melanie Viltard, Neal Paragas, Carrie J Shawber, Wenqiang Yu, Peter Lee, Xia Chen, Abby Sarkar, Weiyi Mu, Alexander Rittenberg, Chyuan-Sheng Lin, Jan Kitajewski, Qais Al-Awqati, Jonathan Barasch

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TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer by Dexiang Zhang, Pinxiang Lu, Kaihua Zhu, Haixia Wu, Yuedi Dai

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Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis by Jinbeom Heo, Byeong‐Joo Noh, Seungun Lee, Hye‐Yeon Lee, YongHwan Kim, Jisun Lim, Hyein Ju, Hwan Yeul Yu, Chae‐Min Ryu, Peter CW Lee, Hwangkyo Jeong, Yumi Oh, Kyunggon Kim, Sang‐Yeob Kim, Jaekyoung Son, Bumsik Hong, Jong Soo Kim, Yong Mee Cho, Dong‐Myung Shin

“…Lack of TFCP2L1 phosphorylation impaired the tumorigenic potency of BC cells in a xenograft model. …”
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Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis by Yuan Li, Dan Li, Jingyu Wang, Jinlong Tang

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Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1 by Fabian L. Cardenas-Diaz, Derek C. Liberti, John P. Leach, Apoorva Babu, Jonathan Barasch, Tian Shen, Maria A. Diaz-Miranda, Su Zhou, Yun Ying, Danielle A. Callaway, Michael P. Morley, Edward E. Morrisey

“…Tfcp2l1 loss in adult AT2 cells inhibits self-renewal and enhances AT2-AT1 differentiation during tissue regeneration. …”
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circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma by Jianfei Zhang, Yanlin Cai, Shunliang Sheng, Congling Zhao, Bin Jiang

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Correction: CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer by Ya Liu, Xiao Zhang, Jiafei Lin, Yuxin Chen, Yongxia Qiao, Susu Guo, Yueyue Yang, Guoqing Zhu, Qiuhui Pan, Jiayi Wang, Fenyong Sun

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Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins by Sarah A. Yunes, Jennifer L. S. Willoughby, Julian H. Kwan, Jessica M. Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A. York, Kuan-Chung Su, Kelly George, Jagesh V. Shah, Andrew Emili, Scott E. Schaus, Ulla Hansen

“…Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. …”
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Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins. by Sarah A Yunes, Jennifer L S Willoughby, Julian H Kwan, Jessica M Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A York, Kuan-Chung Su, Kelly George, Jagesh V Shah, Andrew Emili, Scott E Schaus, Ulla Hansen

“…Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. …”
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Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro by Sophie Kraunsoe, Takuya Azami, Yihan Pei, Graziano Martello, Kenneth Jones, Thorsten Boroviak, Jennifer Nichols

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Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency by Dongbo Qiu, Shoudong Ye, Bryan Ruiz, Xingliang Zhou, Dahai Liu, Qi Zhang, Qi-Long Ying

“…Conversely, downregulation of Klf2 and Tfcp2l1 impairs ESC self-renewal mediated by Wnt/β-catenin signaling. …”
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SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance by Bujamin H. Vokshi, Guillaume Davidson, Nassim Tawanaie Pour Sedehi, Alexandra Helleux, Marc Rippinger, Alexandre R. Haller, Justine Gantzer, Jonathan Thouvenin, Philippe Baltzinger, Rachida Bouarich, Valeria Manriquez, Sakina Zaidi, Priya Rao, Pavlos Msaouel, Xiaoping Su, Hervé Lang, Thibault Tricard, Véronique Lindner, Didier Surdez, Jean-Emmanuel Kurtz, Franck Bourdeaut, Nizar M. Tannir, Irwin Davidson, Gabriel G. Malouf

“…Using single-cell sequencing of human RMC, we defined transformation of thick ascending limb (TAL) cells into an epithelial-mesenchymal gradient of RMC cells associated with loss of renal epithelial transcription factors TFCP2L1, HOXB9 and MITF and gain of MYC and NFE2L2-associated oncogenic and ferroptosis resistance programs. …”
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Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma by Yikun Wang, Shiyu Qiu, Hong Wang, Jiangtao Cui, Xiaoting Tian, Yayou Miao, Congcong Zhang, Leiqun Cao, Lifang Ma, Xin Xu, Yongxia Qiao, Xiao Zhang

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MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal by Yan Zhang, Huiwen Ding, Xiaoxiao Wang, Xin Wang, Shengpeng Wan, Anchun Xu, Ruoyi Gan, Shou-Dong Ye

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TFCP2L1 as a potential diagnostic gene biomarker of Keloid given its association with immune cells-a study based on machine learning and RNA sequence by Jia Huang, Yiyi Gong, Jui-Ming Lin, Haowei Lu, Jun Chen, Ke Liu, Jinran Lin, Wenyu Wu, Xiaobo Zhou

“…These findings highlight the intertwined roles of TFCP2L1 and immune cell infiltration, lending to TFCP2L1’s potential as a diagnostic biomarker for keloids and highlights how TFCP2L1 might influence keloid development through immune cell populations.…”
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The genetic and epigenetic regulation of CD55 and its pathway analysis in colon cancer by Jiawei Liu, Jiawei Liu, Ning Fu, Zhenbang Yang, Ang Li, Hongjiao Wu, Ye Jin, Qinqin Song, Shanshan Ji, Hongxue Xu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang

“…The mRNA and protein expression levels of TFCP2 were reduced by si-TFCP2. NF-κB mRNA was obviously reduced by NF-κB inhibitor and increased by NF-κB activator. …”
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Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy by Haitao Zhang, Guodong Gao, Yu Zhang, Yang Sun, Huanfa Li, Shan Dong, Wei Ma, Bei Liu, Weiwen Wang, Hao Wu, Hua Zhang

“…Transcription factor CP2 (TFCP2) regulates ASIC2a expression. We report that suppressed TFCP2 expression and elevated ASIC2a expression were associated with glucose hypometabolism in the hippocampi of humans with epilepsy and of rat epilepsy model brains. …”
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