Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system (CNS) in Alzheimer’s disease (AD) by Yuhai eZhao, James M Hill, Surjyadipta eBhattacharjee, Maire E. Percy, Aileen I.D. Pogue, Walter J Lukiw

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Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum by Yi-He Chen, Rong-Rong Lin, Hui-Feng Huang, Yan-Yan Xue, Qing-Qing Tao

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Serum soluble triggering receptor levels expressed on myeloid cells2 identify early acute kidney injury in infants and young children after pediatric cardiopulmonary bypass by Mingwei Sun, Mingwei Sun, Lijun Yang, Lijun Yang, Qing Zong, Qing Zong, Liyang Ying, Xiwang Liu, Ru Lin, Ru Lin

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Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments by Premranjan Kumar, Jayshree Mishra, Narendra Kumar

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A Shotgun Proteomic Platform for a Global Mapping of Lymphoblastoid Cells to Gain Insight into Nasu-Hakola Disease by Antonella De Palma, Anna Maria Agresta, Simona Viglio, Rossana Rossi, Maura D’Amato, Dario Di Silvestre, Pierluigi Mauri, Paolo Iadarola

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Shifting paradigms: The central role of microglia in Alzheimer's disease by Tina Schwabe, Karpagam Srinivasan, Herve Rhinn

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New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer’s Disease and Its Potential for Therapeutic Intervention by Tiantian Li, Li Lu, Eloise Pember, Xinuo Li, Bocheng Zhang, Zheying Zhu

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Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery by Johanna Ruhnau, Jonas Müller, Stephan Nowak, Sarah Strack, Denise Sperlich, Anna Pohl, Jasmin Dilz, Angelika Saar, Yannick Veser, Frederik Behr, Sebastian Rehberg, Taras Usichenko, Klaus Hahnenkamp, Johannes Ehler, Agnes Flöel, Henry W. S. Schroeder, Jan-Uwe Müller, Robert Fleischmann, Antje Vogelgesang

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GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease by Sarah M. Connor, Mamunur Rashid, Katie J. Ryan, Kruti Patel, Justin D. Boyd, Jennifer Smith, Wassim Elyaman, Wassim Elyaman, David A. Bennett, Elizabeth M. Bradshaw, Elizabeth M. Bradshaw

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A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration by Mei-Ling Tian, Xiao-Neng Ni, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Lan Tan, Lan Tan, for the Alzheimer’s Disease Neuroimaging Initiative

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

“…To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2 ko) at ages ranging from 4 to 22 months. …”
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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A., Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V.

“…To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2 ko) at ages ranging from 4 to 22 months. …”
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Commentary: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Sachchida Nand Rai, Vivek K. Chaturvedi, Brijesh Kumar Singh, Mohan P. Singh

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Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer’s Disease by Sujin Kim, Hyunju Chung, Han Ngoc Mai, Yunkwon Nam, Soo Jung Shin, Yong Ho Park, Mi Joo Chung, Jong Kil Lee, Hak Young Rhee, Geon-Ho Jahng, Youngkyong Kim, Yu Jin Lim, Moonkyoo Kong, Minho Moon, Weon Kuu Chung

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DNA Methylation Changes in Intron 1 of Triggering Receptor Expressed on Myeloid Cell 2 in Japanese Schizophrenia Subjects by Yuta Yoshino, Yuki Ozaki, Kiyohiro Yamazaki, Tomoko Sao, Yoko Mori, Shinichiro Ochi, Jun-ichi Iga, Shu-ichi Ueno

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Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure by Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari

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Glial activation and inflammation along the Alzheimer’s disease continuum by Kaja Nordengen, Bjørn-Eivind Kirsebom, Kristi Henjum, Per Selnes, Berglind Gísladóttir, Marianne Wettergreen, Silje Bøen Torsetnes, Gøril Rolfseng Grøntvedt, Knut K. Waterloo, Dag Aarsland, Lars N. G. Nilsson, Tormod Fladby

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Soluble Triggering Receptor Expressed on Myeloid Cells 2 From Cerebrospinal Fluid in Sleep Disorders Related to Parkinson’s Disease by Mingshu Mo, Yuting Tang, Lijian Wei, Jiewen Qiu, Guoyou Peng, Yuwan Lin, Miaomiao Zhou, Wei Dai, Zhiling Zhang, Xiang Chen, Hanqun Liu, Liuyan Ding, Panghai Ye, Yijuan Wu, Xiaoqin Zhu, Zhuohua Wu, Wenyuan Guo, Pingyi Xu

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TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders by Gianfranco Natale, Francesca Biagioni, Carla Letizia Busceti, Stefano Gambardella, Fiona Limanaqi, Francesco Fornai

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Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure by Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng, Yingzi Ming

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