Showing 361 - 380 results of 589 for search '"TREM2"', query time: 0.92s Refine Results
  1. 361

    Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia by Ishan Agrawal, Sushmita Jha

    Published 2020-08-01
    “…Aβ interacts with microglial receptors, such as triggering receptor expressed in myeloid cells 2 (TREM2), activating downstream pathways causing mitochondrial damage and aggravating inflammation and cytotoxicity. …”
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    Article
  2. 362

    Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy by Kevin A. Clayton, Alicia A. Van Enoo, Tsuneya Ikezu, Tsuneya Ikezu

    Published 2017-12-01
    “…This is genetically supported by the association of microglia-specific genes, TREM2 and CD33, and late onset Alzheimer's disease. …”
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    Article
  3. 363

    Can mouse models mimic sporadic Alzheimer’s disease? by Bettina M Foidl, Christian Humpel

    Published 2020-01-01
    “…Several risk genes, such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD, but also many risk factors associated with life style (e.g., diabetes, hypercholesterolemia, stress) may play a role. …”
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    Article
  4. 364

    Chronic traumatic encephalopathy: Diagnostic updates and advances by Kevin Pierre, Vanessa Molina, Shil Shukla, Anthony Avila, Nicholas Fong, Jessica Nguyen, Brandon Lucke-Wold

    Published 2022-12-01
    “…For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.…”
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    Article
  5. 365

    Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management by Kevin Pierre, Kyle Dyson, Abeer Dagra, Eric Williams, Ken Porche, Brandon Lucke-Wold

    Published 2021-04-01
    “…Furthermore, we highlight the recent advances in diagnosis using diffusor tensor imaging, functional magnetic resonance imaging, positron emission tomography, and the fluid biomarkers t-tau, sTREM2, CCL11, NFL, and GFAP. We also provide an update on emerging pharmaceutical treatments, including immunotherapies and those that target tau acetylation, tau phosphorylation, and inflammation. …”
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    Article
  6. 366

    Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk by Anastasia G. Efthymiou, Alison M. Goate

    Published 2017-05-01
    “…Of these genes, several (including CR1, SPI1, the MS4As, TREM2, ABCA7, CD33, and INPP5D) are expressed by microglia, the resident immune cells of the brain. …”
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    Article
  7. 367

    T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease. by Yair Fisher, Anna Nemirovsky, Rona Baron, Alon Monsonego

    Published 2010-01-01
    “…Furthermore, while a single vaccination with Abeta resulted in upregulation of the phagocytic markers triggering receptors expressed on myeloid cells-2 (TREM2) and signal regulatory protein-beta1 (SIRPbeta1) in the brain, it caused downregulation of the proinflammatory cytokines TNF-alpha and IL-6. …”
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    Article
  8. 368

    Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease by Vishal Chavda, Kavita Singh, Vimal Patel, Meerambika Mishra, Awdhesh Kumar Mishra

    Published 2022-01-01
    “…In the present review, we scrutinize different interactions and important factors including direct cell–cell contact, intervention by the CD200 system, various receptors present on their surfaces, CXC3RI and TREM2, and chemokines and cytokines with special reference to Alzheimer’s disease (AD). …”
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    Article
  9. 369

    Association of TREM-1, IL-1β, IL-33/ST2, and TLR Expressions With the Pathogenesis of Ocular Toxoplasmosis in Mouse Models on Different Genetic Backgrounds by Yanxia Zhang, Yanxia Zhang, Jian He, Jian He, Jian He, Huanqin Zheng, Huanqin Zheng, Shiguang Huang, Fangli Lu, Fangli Lu

    Published 2019-10-01
    “…The signaling of triggering receptor expressed on myeloid cells (TREM)-1 amplifies inflammation, whereas TREM-2 signaling is anti-inflammatory. IL-1β is a major driver of inflammation during infection. …”
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    Article
  10. 370

    The Alzheimer's Cell Atlas (TACA): A single‐cell molecular map for translational therapeutics accelerator in Alzheimer's disease by Yadi Zhou, Jielin Xu, Yuan Hou, Lynn Bekris, James B. Leverenz, Andrew A. Pieper, Jeffrey Cummings, Feixiong Cheng

    Published 2022-01-01
    “…Major comparison types are (1) AD versus healthy control; (2) sex‐specific DE, (3) genotype‐driven DE (i.e., apolipoprotein E [APOE] ε4/ε4 vs APOE ε3/ε3; TREM2R47H vs common variants) analysis; and (4) others. …”
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    Article
  11. 371

    Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration by Mar Puigdellívol, David H. Allendorf, Guy C. Brown

    Published 2020-06-01
    “…Activated microglia also release galectin-3 (Gal-3), which: (i) further activates microglia via binding to TLR4 and TREM2, (ii) binds to desialylated neurons opsonizing them for phagocytosis via Mer tyrosine kinase, and (iii) promotes Aβ aggregation and toxicity in vivo. …”
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    Article
  12. 372

    Targeting Microglia-Synapse Interactions in Alzheimer’s Disease by Gaia Piccioni, Dalila Mango, Amira Saidi, Massimo Corbo, Robert Nisticò

    Published 2021-02-01
    “…In this context, we highlight microglial TREM2 and CSF1R as emerging targets for disease-modifying therapy in Alzheimer’s disease (AD) and other neurodegenerative disorders.…”
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    Article
  13. 373

    Positron Emission Tomography in the Inflamed Cerebellum: Addressing Novel Targets among G Protein-Coupled Receptors and Immune Receptors by Margit Pissarek

    Published 2020-09-01
    “…The sphingosine 1 phosphate receptor 1 (S1P1), neuropeptide Y receptor 2 (NPY2) and purinoceptor Y12 (P2Y12) cannabinoid receptors and the chemokine receptor CX3CR1 as G-protein-coupled receptors and the ionotropic purinoceptor P2X7 provide structures with rather classical binding behavior, while the immune receptor for advanced glycation end products (RAGE) and the triggering receptor expressed on myeloid cells 2 (TREM2) might depend for instance on further accessory proteins. …”
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    Article
  14. 374

    Genes associated with Alzheimer's disease: an overview and current status by Giri M, Zhang M, Lü Y

    Published 2016-05-01
    “…Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. …”
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    Article
  15. 375

    Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors by Zoë P. Van Acker, Marine Bretou, Wim Annaert

    Published 2019-06-01
    “…In this review we discuss our current knowledge of the risk genes APOE4, BIN1, CD2AP, PICALM, PLD3 and TREM2 and their impact on endolysosomal (dys)regulations in the light of late-onset Alzheimer’s disease pathology.…”
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    Article
  16. 376

    Alzheimer’s Disease Research Using Human Microglia by Lih-Fen Lue, Thomas G. Beach, Douglas G. Walker

    Published 2019-08-01
    “…In recent years, interest in human microglia and neuroinflammation has been renewed due to the identification of inflammation-related AD genetic risk factors, in particular the triggering receptor expressed on myeloid cells (TREM)-2. Because of the difficulties in developing effective treatments for AD, there has been a general need for greater understanding of the functions of microglia in normal and AD brains. …”
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    Article
  17. 377

    Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype. by Charlotte Gustafsson, Jenny Mjösberg, Andreas Matussek, Robert Geffers, Leif Matthiesen, Göran Berg, Surendra Sharma, Jan Buer, Jan Ernerudh

    Published 2008-04-01
    “…Further, the selective up-regulation of triggering receptor expressed on myeloid cells (TREM)-2, alpha-2-macroglobulin (A2M) and prostaglandin D2 synthase (PGDS) provides new insights into the regulatory function of decidual macrophages in pregnancy that may have implications in pregnancy complications.The molecular characterization of decidual macrophages presents a unique transcriptional profile replete with important components for fetal immunoprotection and provides several clues for further studies of these cells.…”
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    Article
  18. 378

    A rare treatable cause for atypical frontotemporal dementia with multiple fractures in a young female by Sadanandavalli Retnaswami Chandra, Neeraja Koti, Ganaraja Valakunja Harikrishna, Pooja Mailankody, C Nitin Ramanujam, S Mathuranath Pavagada, Thomas Gregor Issac

    Published 2018-01-01
    “…Genetic testing with whole exome sequencing showed TREM2 (-) (ENST00000373113) Exon 2 c.377T>G (p.Val126Gly) Homozygous Autosomal recessive. …”
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    Article
  19. 379

    Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia by Edward S. Wickstead

    Published 2023-08-01
    “…Of the risk genes identified, many have been associated with the immune system, including <i>ABCA7</i>, <i>CLU</i>, <i>MEF2C</i>, <i>PICALM</i> and <i>TREM2</i>—genes known to be highly expressed in microglia. …”
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    Article
  20. 380

    The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume by Lupton, MK, Strike, L, Hansell, NK, Wen, W, Mather, KA, Armstrong, NJ, Thalamuthu, A, McMahon, KL, De Zubicaray, GI, Assareh, AA, Simmons, A, Proitsi, P, Powell, JF, Montgomery, GW, Hibar, DP, Westman, E, Tsolaki, M, Kloszewska, I, Soininen, H, Mecocci, P, Velas, B, Lovestone, S, Brodaty, H, Ames, D, Trollor, JN, Martin, NG, Thompson, PM, Sachdev, PS, Wright, MJ

    Published 2016
    “…An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. …”
    Journal article