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361
Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia
Published 2020-08-01“…Aβ interacts with microglial receptors, such as triggering receptor expressed in myeloid cells 2 (TREM2), activating downstream pathways causing mitochondrial damage and aggravating inflammation and cytotoxicity. …”
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362
Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
Published 2017-12-01“…This is genetically supported by the association of microglia-specific genes, TREM2 and CD33, and late onset Alzheimer's disease. …”
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363
Can mouse models mimic sporadic Alzheimer’s disease?
Published 2020-01-01“…Several risk genes, such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD, but also many risk factors associated with life style (e.g., diabetes, hypercholesterolemia, stress) may play a role. …”
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364
Chronic traumatic encephalopathy: Diagnostic updates and advances
Published 2022-12-01“…For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.…”
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365
Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management
Published 2021-04-01“…Furthermore, we highlight the recent advances in diagnosis using diffusor tensor imaging, functional magnetic resonance imaging, positron emission tomography, and the fluid biomarkers t-tau, sTREM2, CCL11, NFL, and GFAP. We also provide an update on emerging pharmaceutical treatments, including immunotherapies and those that target tau acetylation, tau phosphorylation, and inflammation. …”
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366
Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
Published 2017-05-01“…Of these genes, several (including CR1, SPI1, the MS4As, TREM2, ABCA7, CD33, and INPP5D) are expressed by microglia, the resident immune cells of the brain. …”
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367
T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease.
Published 2010-01-01“…Furthermore, while a single vaccination with Abeta resulted in upregulation of the phagocytic markers triggering receptors expressed on myeloid cells-2 (TREM2) and signal regulatory protein-beta1 (SIRPbeta1) in the brain, it caused downregulation of the proinflammatory cytokines TNF-alpha and IL-6. …”
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368
Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease
Published 2022-01-01“…In the present review, we scrutinize different interactions and important factors including direct cell–cell contact, intervention by the CD200 system, various receptors present on their surfaces, CXC3RI and TREM2, and chemokines and cytokines with special reference to Alzheimer’s disease (AD). …”
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369
Association of TREM-1, IL-1β, IL-33/ST2, and TLR Expressions With the Pathogenesis of Ocular Toxoplasmosis in Mouse Models on Different Genetic Backgrounds
Published 2019-10-01“…The signaling of triggering receptor expressed on myeloid cells (TREM)-1 amplifies inflammation, whereas TREM-2 signaling is anti-inflammatory. IL-1β is a major driver of inflammation during infection. …”
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370
The Alzheimer's Cell Atlas (TACA): A single‐cell molecular map for translational therapeutics accelerator in Alzheimer's disease
Published 2022-01-01“…Major comparison types are (1) AD versus healthy control; (2) sex‐specific DE, (3) genotype‐driven DE (i.e., apolipoprotein E [APOE] ε4/ε4 vs APOE ε3/ε3; TREM2R47H vs common variants) analysis; and (4) others. …”
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371
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
Published 2020-06-01“…Activated microglia also release galectin-3 (Gal-3), which: (i) further activates microglia via binding to TLR4 and TREM2, (ii) binds to desialylated neurons opsonizing them for phagocytosis via Mer tyrosine kinase, and (iii) promotes Aβ aggregation and toxicity in vivo. …”
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372
Targeting Microglia-Synapse Interactions in Alzheimer’s Disease
Published 2021-02-01“…In this context, we highlight microglial TREM2 and CSF1R as emerging targets for disease-modifying therapy in Alzheimer’s disease (AD) and other neurodegenerative disorders.…”
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373
Positron Emission Tomography in the Inflamed Cerebellum: Addressing Novel Targets among G Protein-Coupled Receptors and Immune Receptors
Published 2020-09-01“…The sphingosine 1 phosphate receptor 1 (S1P1), neuropeptide Y receptor 2 (NPY2) and purinoceptor Y12 (P2Y12) cannabinoid receptors and the chemokine receptor CX3CR1 as G-protein-coupled receptors and the ionotropic purinoceptor P2X7 provide structures with rather classical binding behavior, while the immune receptor for advanced glycation end products (RAGE) and the triggering receptor expressed on myeloid cells 2 (TREM2) might depend for instance on further accessory proteins. …”
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374
Genes associated with Alzheimer's disease: an overview and current status
Published 2016-05-01“…Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. …”
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375
Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
Published 2019-06-01“…In this review we discuss our current knowledge of the risk genes APOE4, BIN1, CD2AP, PICALM, PLD3 and TREM2 and their impact on endolysosomal (dys)regulations in the light of late-onset Alzheimer’s disease pathology.…”
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376
Alzheimer’s Disease Research Using Human Microglia
Published 2019-08-01“…In recent years, interest in human microglia and neuroinflammation has been renewed due to the identification of inflammation-related AD genetic risk factors, in particular the triggering receptor expressed on myeloid cells (TREM)-2. Because of the difficulties in developing effective treatments for AD, there has been a general need for greater understanding of the functions of microglia in normal and AD brains. …”
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377
Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype.
Published 2008-04-01“…Further, the selective up-regulation of triggering receptor expressed on myeloid cells (TREM)-2, alpha-2-macroglobulin (A2M) and prostaglandin D2 synthase (PGDS) provides new insights into the regulatory function of decidual macrophages in pregnancy that may have implications in pregnancy complications.The molecular characterization of decidual macrophages presents a unique transcriptional profile replete with important components for fetal immunoprotection and provides several clues for further studies of these cells.…”
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378
A rare treatable cause for atypical frontotemporal dementia with multiple fractures in a young female
Published 2018-01-01“…Genetic testing with whole exome sequencing showed TREM2 (-) (ENST00000373113) Exon 2 c.377T>G (p.Val126Gly) Homozygous Autosomal recessive. …”
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379
Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia
Published 2023-08-01“…Of the risk genes identified, many have been associated with the immune system, including <i>ABCA7</i>, <i>CLU</i>, <i>MEF2C</i>, <i>PICALM</i> and <i>TREM2</i>—genes known to be highly expressed in microglia. …”
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380
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Published 2016“…An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. …”
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