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381
The Genetics of Alzheimer’s Disease in the Chinese Population
Published 2020-03-01“…In recent years, through the advancement of genome-wide association studies, second-generation gene sequencing technology, and their application in AD genetic research, more genetic loci associated with the risk for AD have been discovered, including <i>KCNJ15</i>, <i>TREM2,</i> and <i>GCH1</i>, which provides new ideas for the etiology and treatment of AD. …”
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382
The Role of White Matter Dysfunction and Leukoencephalopathy/Leukodystrophy Genes in the Aetiology of Frontotemporal Dementias: Implications for Novel Approaches to Therapeutics
Published 2021-03-01“…The review highlights the role of common variants and mutations in genes such as <i>CSF1R</i> (<i>colony-stimulating factor 1 receptor</i>), <i>CYP27A1</i> (<i>cytochrome P450 family 27 subfamily A member 1</i>), <i>TREM2</i> (<i>triggering receptor expressed on myeloid cells 2</i>) and <i>TMEM106B</i> (<i>transmembrane protein 106B</i>) that play an integral role in microglia and oligodendrocyte function. …”
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383
The superiority and feasibility of 2,3,5‐triphenyltetrazolium chloride–stained brain tissues for molecular biology experiments based on microglial properties
Published 2023-04-01“…Results There was no protein and RNA degradation in the TTC‐stained brain tissue group. However, the TREM2 specifically expressed on the microglia showed a significant difference between two groups in the penumbra region. …”
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384
Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.
Published 2013-01-01“…Lastly, expression of several genes involved in osteoclast or bone-resident macrophage function, most notably TREM2 and DAP12, was upregulated in persistently infected mouse spinal cord. …”
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385
Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies
Published 2023-04-01“…The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. …”
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386
Alleviation of monocyte exhaustion by BCG derivative mycolic acid
Published 2024-02-01“…M-MA treatment restored mitochondrial functions of exhausted monocytes and alleviated their suppressive activities on co-cultured T cells. Independent of TREM2, M-MA blocks Src-STAT1-mediated inflammatory polarization and reduces the production of immune suppressors TAX1BP1 and PLAC8. …”
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387
The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS
Published 2017-06-01“…Nasu-Hakola (NHD) disease is considered a primary microgliopathy with alterations of the DNAX activation protein 12 (DAP12)-Triggering receptor expressed on myeloid cells 2 (TREM-2) signaling and removal of macromolecules and apoptotic cells followed by secondary microglia activation. …”
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388
Molecular and immunological features of TREM1 and its emergence as a prognostic indicator in glioma
Published 2024-02-01“…In this study, the prognostic value and functional roles of TREM2 in glioma were analyzed. TERM1 was observed to be significantly upregulated in GBM compared to in other grade gliomas and was associated with poor prognosis. …”
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389
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Published 2020“…This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTKposTREM2high and MerTKposLYVE1pos) with unique remission transcriptomic signatures enriched in negative regulators of inflammation. …”
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390
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Published 2020“…This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTKposTREM2high and MerTKposLYVE1pos) with unique remission transcriptomic signatures enriched in negative regulators of inflammation. …”
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391
Adipoclast: a multinucleated fat-eating macrophage
Published 2021-11-01“…Specifically, we highlight the role of CD9 and TREM2, two plasma membrane markers of lipid-associated macrophages in WAT, which have been previously described as regulators of fusion and multinucleation in osteoclasts and MGCs. …”
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392
Syk inhibitors protect against microglia-mediated neuronal loss in culture
Published 2023-03-01“…Microglial inflammation and phagocytosis are thought to be regulated by spleen tyrosine kinase (Syk), which is activated by multiple microglial receptors, including TREM2 (Triggering Receptor Expressed on Myeloid Cells 2), implicated in neurodegeneration. …”
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393
Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells
Published 2010-11-01“…During differentiation, the H3K4me3 levels decreased on monocyte-specific CD14, CCR2 and CX3CR1 but increased on DC-specific TM7SF4/DC-STAMP, TREM2 and CD209/DC-SIGN genes. Genes associated with phagocytosis and antigen presentation were marked by H3K4me3 modifications. …”
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394
Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease
Published 2020-06-01“…Genes associated with immune system dysfunction in Alzheimer's disease include CLU, BIN1, CR1, ABCA7, HLA-DRB1, TREM2, EPHA1, and CD2AP. In particular, BIN1 and CLU, aberrations in which are thought to promote neurodegeneration by dysregulating exocytosis and immune processes, together with the E4 variant of the APOE gene, are among the most common genetic risk factors for Alzheimer's disease. …”
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395
Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals
Published 2023-08-01“…There are several phytochemicals (e.g., curcumin, EGCG, fucoidan, galangin, astin C, apigenin, resveratrol, phytic acid, acacetin, daucosterol, silibinin, sulforaphane, withaferin A, and betulinic acid) that modulate the dysfunction of one or several key genes (e.g., TREM2, C3, C3aR1, TNFA, NF-kb, TGFB1&2, SIRT1&6, HMGB1, and STING) affected in the aged brain. …”
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396
Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms
Published 2022-04-01“…By using scRNA-seq, three main clusters including resident-like, inflammatory, and triggering receptor expressed on myeloid cells-2 (Trem2hi) are identified as the major subtypes of monocyte-derived foam cells in atherosclerotic plaques. …”
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397
Microglia in Alzheimer’s Disease in the Context of Tau Pathology
Published 2020-10-01“…In addition, we analyze the impact of microglial AD-risk genes (<i>APOE</i>, <i>TREM2,</i> and <i>CD33</i>) in tau pathology, and we discuss the role of extracellular soluble tau in neuroinflammation.…”
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398
Intersection of pathological tau and microglia at the synapse
Published 2019-07-01“…Furthermore, AD risk genes such as Triggering receptor expressed on myeloid cells 2 (TREM2) and Apolipoprotein E (APOE) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. …”
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399
Novel galectin-3 roles in neurogenesis, inflammation and neurological diseases
Published 2021“…It is a natural ligand for TREM2 (triggering receptor expressed on myeloid cells), TLR4 (Toll-like receptor 4), and IR (insulin receptor). …”
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400
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
Published 2019-07-01“…Upon coming into vicinity of Aβ, microglia get activated, endocytose Aβ, and contribute toward their clearance via TREM2 surface receptors, simultaneously triggering innate immunoresponse against the aggregation. …”
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