Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis by Chieh-Yu Liao, Fanta Barrow, Nanditha Venkatesan, Yasuhiko Nakao, Amy S. Mauer, Gavin Fredrickson, Myeong Jun Song, Myeong Jun Song, Tejasav S. Sehrawat, Debanjali Dasgupta, Rondell P. Graham, Xavier S. Revelo, Harmeet Malhi

“…Etrasimod treated mouse livers demonstrated an increase in non-inflammatory (Marco) and lipid associated (Trem2) macrophage markers. Thus, S1P1,4,5 modulation by Etrasimod is more effective than S1P1 antagonism by Amiselimod, at the dose tested, in ameliorating NASH, likely due to the alteration of leukocyte trafficking and recruitment. …”
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SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease by Erica Novo, Andrea Cappon, Gianmarco Villano, Santina Quarta, Stefania Cannito, Claudia Bocca, Cristian Turato, Maria Guido, Marina Maggiora, Francesca Protopapa, Salvatore Sutti, Alessia Provera, Mariagrazia Ruvoletto, Alessandra Biasiolo, Beatrice Foglia, Emanuele Albano, Patrizia Pontisso, Maurizio Parola

“…The opposite changes in liver macrophage activation observed in TG/SB3 or KO/SB3 mice with NASH were associated with a parallel modulation in the expression of triggering receptor expressed on myeloid cells-2 (TREM2), CD9 and galectin-3 markers, recently detected in NASH-associated macrophages. …”
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Exome Sequencing of a Portuguese Cohort of Frontotemporal Dementia Patients: Looking Into the ALS-FTD Continuum by Miguel Tábuas-Pereira, Miguel Tábuas-Pereira, Miguel Tábuas-Pereira, Isabel Santana, Isabel Santana, Isabel Santana, Isabel Santana, Elizabeth Gibbons, Kimberly Paquette, Maria Rosário Almeida, Inês Baldeiras, Inês Baldeiras, Inês Baldeiras, Inês Baldeiras, Jose Bras, Jose Bras, Rita Guerreiro, Rita Guerreiro

“…We performed exome sequencing and 1) prioritized potential FTD and ALS causing variants by using Exomiser to annotate and filter results; and 2) looked specifically at rare variability in genes associated with FTD (excluding GRN, MAPT and C9ORF72) and/or ALS.ResultsWe identified 13 rare missense variants in 10 patients (three patients had two variants) in the following genes: FUS, OPTN, CCNF, DCTN1, TREM2, ERBB4, ANG, CHRNA4, CHRNB4 and SETX. We found an additional frameshift variant on GLT8D1 in one patient. …”
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Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology by Chao Song, Shufang Li, Yingren Mai, Linpeng Li, Guoku Dai, Yuan Zhou, Xiaosheng Liang, Olivia Meilan Zou, Ya Wang, Libing Zhou, Jun Liu, Yi Zou

“…Immunohistology analysis revealed increased neurite dystrophy that correlated with the reduced microglial chemotaxis in the hippocampi of these mice, independent of the other two ADAM10 substrates (neuronal CX3CL1 and microglial TREM2) that were involved in regulating the microglial immunoactivity. …”
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Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia by Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R. Davis, Jered W. Wilson, Milica A. Margeta, Kristen M. Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L. Graham, Vivek K. Gupta, Keith L. Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaoui

“…Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional regulator of MGnD microglial phenotype. …”
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Tracking neuroinflammatory biomarkers in Alzheimer’s disease: a strategy for individualized therapeutic approaches? by Simone Lista, Bruno P. Imbimbo, Margherita Grasso, Annamaria Fidilio, Enzo Emanuele, Piercarlo Minoretti, Susana López-Ortiz, Juan Martín-Hernández, Audrey Gabelle, Giuseppe Caruso, Marco Malaguti, Daniela Melchiorri, Alejandro Santos-Lozano, Camillo Imbimbo, Michael T. Heneka, Filippo Caraci

“…Genome-wide association studies identified robust associations between AD and several AD risk genes related to immune response, including but not restricted to CD33 and TREM2. Here, we critically reviewed the current knowledge on candidate neuroinflammatory biomarkers and their role in characterizing the pathophysiology of AD. …”
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Fibroblast growth factor receptor 3 mutation attenuates response to immune checkpoint blockade in metastatic urothelial carcinoma by driving immunosuppressive microenvironment by Tao Xu, Yulong Wang, Caipeng Qin, Yiqing Du, Yuxuan Song, Yun Peng, Wenbo Yang

“…FGFR3-mutated UC exhibited less immune infiltration, and lower T-cell cytotoxicity. Higher TREM2+ macrophage abundance in FGFR3-mutated UC can undermine and suppress the T cells, potentially contributing to the formation of an immunosuppressive microenvironment. …”
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Dementia-related genetic variants in an Italian population of early-onset Alzheimer’s disease by Anna Bartoletti-Stella, Martina Tarozzi, Giacomo Mengozzi, Francesca Asirelli, Laura Brancaleoni, Laura Brancaleoni, Nicola Mometto, Michelangelo Stanzani-Maserati, Simone Baiardi, Simone Baiardi, Simona Linarello, Marco Spallazzi, Roberta Pantieri, Elisa Ferriani, Paolo Caffarra, Rocco Liguori, Rocco Liguori, Piero Parchi, Piero Parchi, Sabina Capellari, Sabina Capellari

“…Additionally, 7.84% of patients had a moderate risk allele in PSEN1, PSEN2, or TREM2 genes. Besides, we observed that 12.75% of our patients carried only a variant in genes associated with other neurodegenerative diseases. …”
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Association of modified dementia risk score with cerebrospinal fluid biomarkers and cognition in adults without dementia by Qiong-Yao Li, Yan Fu, Xin-Jing Cui, Zuo-Teng Wang, Zuo-Teng Wang, Lan Tan, Lan Tan, for the Alzheimer’s Disease Neuroimaging Initiative

“…The Alzheimer’s Disease Neuroimaging Initiative (ADNI) study was used to validate the mediation effects and to investigate the longitudinal association between MDRS and cognitive decline.ResultsThe results revealed that higher MDRS were linked to poorer cognitive performance (Model 1: PFDR < 0.001; Model 2: PFDR < 0.001) and increases in CSF levels of phosphorylated tau (P-tau, Model 1: PFDR < 0.001; Model 2: PFDR < 0.001), total tau (T-tau, Model 1: PFDR < 0.001; Model 2: PFDR < 0.001), P-tau/Aβ42 ratio (Model 1: PFDR = 0.023; Model 2: PFDR = 0.028), T-tau/Aβ42 ratio (Model 1: PFDR < 0.001; Model 2: PFDR < 0.001) and soluble triggering receptor expressed on myeloid cells 2 (sTrem2, Model 1: PFDR < 0.001; Model 2: PFDR < 0.001) in the CABLE study. …”
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C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort by Tan, Yi Jayne, Yong, Alisa C. W., Foo, Jia Nee, Lian, Michelle M., Lim, Weng Khong, Dominguez, Jacqueline, Fong, Zhi Hui, Narasimhalu, Kaavya, Chiew, Hui Jin, Ng, Kok Pin, Ting, Simon K. S., Kandiah, Nagaendran, Ng, Adeline S. L.

“…Results: Overall, 26.6% (16/60 cases) carried pathogenic or likely pathogenic variants in a FTD-related gene, including: MAPT Gln351Arg (n = 1); GRN Cys92Ter (n = 1), Ser301Ter (n = 2), c.462 + 1G > C (n = 1); C9orf72 expansion (35–70 repeats; n = 8); TREM2 Arg47Cys (n = 1); and OPTN frameshift insertion (n = 2). …”
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Long-lasting effects of lipopolysaccharide on the reproduction and splenic transcriptome of hens and their offspring by Lei Liu, Di Wang, Xingzheng Li, Adeyinka Abiola Adetula, Adnan Khan, Bing Zhang, Huagui Liu, Ying Yu, Qin Chu

“…The DEGs such as AVD, HPS5, CATHL2, S100A12, EXFABP, RSFR, LY86, PKD4, XCL1, FOS, TREM2 and MST1 may play an essential role in the regulation of the immunity and egg-laying rate of hens. …”
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Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models by Maria Eugenia Marques da Costa, Maria Eugenia Marques da Costa, Robin Droit, Pierre Khneisser, Anne Gomez-Brouchet, Tiphaine Adam-de-Beaumais, Marie Nolla, Nicolas Signolles, Jacob Torrejon, Jacob Torrejon, Bérangère Lombard, Damarys Loew, Olivier Ayrault, Olivier Ayrault, Jean-Yves Scoazec, Birgit Geoerger, Birgit Geoerger, Gilles Vassal, Antonin Marchais, Antonin Marchais, Nathalie Gaspar, Nathalie Gaspar

“…Despite NSG mouse immunodeficiency, four of the PDX models partially reconstructed the vascular and immune-microenvironment observed in patients, among which the macrophagic TREM2/TYROBP axis expression, recently linked to immunosuppression. …”
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Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype by Sara Pinto, Carolina Cunha, Marta Barbosa, Ana R. Vaz, Ana R. Vaz, Dora Brites, Dora Brites

“…Marked elevation of IL-10, Arginase 1, TREM2, RAGE, and TLR4 mRNA levels, together with increased miR-124, miR-146a, and miR-155, at 24 h incubation, suggest the switch to mixed M1 and M2 subpopulations in the exosome-treated N9 microglial cells. …”
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Identification of signature gene set as highly accurate determination of metabolic dysfunction-associated steatotic liver disease progression by Sumin Oh, Yang-Hyun Baek, Sungju Jung, Sumin Yoon, Byeonggeun Kang, Su-hyang Han, Gaeul Park, Je Yeong Ko, Sang-Young Han, Jin-Sook Jeong, Jin-Han Cho, Young-Hoon Roh, Sung-Wook Lee, Gi-Bok Choi, Yong Sun Lee, Won Kim, Rho Hyun Seong, Jong Hoon Park, Yeon-Su Lee, Kyung Hyun Yoo

“…Conclusions We identified a signature gene set (i.e., CAPG, HYAL3, WIPI1, TREM2, SPP1, and RNASE6) with strong potential as a panel of diagnostic genes of MASLD-associated disease.…”
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Dynamic atlas of immune cells reveals multiple functional features of macrophages associated with progression of pulmonary fibrosis by Jiaoyan Lv, Haoxiang Gao, Jie Ma, Jiachen Liu, Yujie Tian, Chunyuan Yang, Mansheng Li, Yue Zhao, Zhimin Li, Xuegong Zhang, Xuegong Zhang, Yunping Zhu, Jianhong Zhang, Jianhong Zhang, Li Wu, Li Wu

“…Our analysis suggested that Gpnmb and Trem2 were both upregulated in macrophages and may play important roles in pulmonary fibrosis progression. …”
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Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study by Yanan Lin, Nannan Yu, Xu Lin, Xiyuan Deng, Fanghao Liu, He Tao, Rui Dong, Bin Wang, Yanlin Bi

“…CSF was extracted after successful spinal-epidural combined puncture, and α-synuclein (α-syn), amyloid beta40 (Aβ40), amyloid beta42 (Aβ42), t-Tau, phosphorylated Tau (p-Tau), progranulin (PGRN) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the CSF were measured by enzyme-linked immunosorbent assays (ELISA). …”
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Programmed cell death-related gene IL20RA facilitates tumor progression and remodels tumor microenvironment in thyroid cancer by Yuqi Wang, Yunlong Zhang, Min Liu, Yu Liu, Yu Zeng, Wei Zhang, Shuping Wu, Linfei Hu, Xianhui Ruan, Xiangqian Zheng, Ming Gao, Jingzhu Zhao

“…We identified four PCD-related genes (NPC2, E2F1, IL20RA, and TREM2) and constructed a risk model that exhibited excellent accuracy in predicting the prognosis of THCA. …”
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Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep by Charles A. Huard, Xueqin Gao, Maria E. Dey Hazra, Rony-Orijit Dey Hazra, Kimberly Lebsock, Jeremiah T. Easley, Peter J. Millett, Johnny Huard

“…Fisetin treatment significantly decreased TREM2 in the lung tissues and showed a trend of downregulation in the liver, spleen, and heart. …”
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Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology by Printha Wijesinghe, Hao Ran Li, Zhengyuan Ai, Matthew Campbell, Si Xuan Chen, Jeanne Xi, Wellington Pham, Wellington Pham, Joanne A. Matsubara, Joanne A. Matsubara

“…Our investigations included microRNAs (miRNAs), their target messenger RNAs (mRNAs), and selected protein markers, including astroglial (Gfap), microglial/macrophage (Iba1 and Trem2) markers, and amyloid precursor protein (APP)/amyloid-β (Aβ) peptides implicated in AD pathogenesis. …”
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Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development by Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Flávia dos Santos Souza, Rafael Carvalho Torres, Juliana Echevarria-Lima, Ana Claudia Celestino Bezerra Leite, Marco Antonio Sales Dantas Lima, Abelardo Queiroz Campos Araújo, Marcus Tulius Teixeira Silva, Otávio de Melo Espíndola

“…To that end, the concentrations of VILIP-1, BDNF, VEGF, β-NGF, TGF-β1, fractalkine/CX3CL1, IL-6, IL-18, and TNF-α, and the soluble forms of TREM-1, TREM-2, and RAGE, were assessed using a multiplex bead-based immunoassay in paired cerebrospinal fluid (CSF) and serum samples from HAM/TSP patients (<i>n</i> = 20), asymptomatic HTLV-1 carriers (AC) (<i>n</i> = 13), and HTLV-1-seronegative individuals (<i>n</i> = 9), with the results analyzed according to the speed of HAM/TSP progression. …”
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